Component

Orthosilicic acid / Si(OH)4

Context-specific entity; species, compartment and exposure are stated on each claim.

27 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Orthosilicic acid in water did not significantly increase endogenous aluminum excretion over 32 hours in five volunteers.

    Orthosilicic acid / Si(OH)4 → Human urinary aluminum excretion source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Water dosing, small human kinetic study.
    limitations
    Different matrix, baseline aluminum and timing may matter; urinary output is not a measurement of brain aluminum.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A separate human study did not reproduce increased aluminum clearance.
    primary_references
    Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10612067/ · DOI 10.1016/s0162-0134(99)00126-9

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 112–118

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Water dosing, small human kinetic study. · source_derived_draft · unverified_draft

    ## silica-aluminum-urine-null A separate human study did not reproduce increased aluminum clearance. Orthosilicic acid in water did not significantly increase endogenous aluminum excretion over 32 hours in five volunteers. Model: Water dosing, small human kinetic study. Limitations: Different matrix, baseline aluminum and timing may matter; urinary output is not a measurement of brain aluminum. Evidence access: Primary abstract Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10612067/ · DOI 10.1016/s0162-0134(99)00126-9
    Complete structured claim and evidence

  2. Beer-derived monosilicic acid ingestion was accompanied by increased urinary aluminum in this study.

    Orthosilicic acid / Si(OH)4 → Human urinary aluminum excretion source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Healthy volunteers; beverage matrix and isotope experiments.
    limitations
    Kidney-lumen complex formation and reduced reabsorption were proposed, not directly established molecular targets.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A renal effect was proposed in addition to intestinal binding.
    primary_references
    The role of silicic acid in the renal excretion of aluminium. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8726215/

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 104–110

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Healthy volunteers; beverage matrix and isotope experiments. · source_derived_draft · unverified_draft

    ## silica-aluminum-urine-positive A renal effect was proposed in addition to intestinal binding. Beer-derived monosilicic acid ingestion was accompanied by increased urinary aluminum in this study. Model: Healthy volunteers; beverage matrix and isotope experiments. Limitations: Kidney-lumen complex formation and reduced reabsorption were proposed, not directly established molecular targets. Evidence access: Primary abstract The role of silicic acid in the renal excretion of aluminium. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8726215/
    Complete structured claim and evidence

  3. Ten micromolar orthosilicic acid increased BMP2 expression in human osteoblast-like cells.

    Orthosilicic acid / Si(OH)4 → Human BMP2 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human MG-63/U2-OS cell program.
    limitations
    Expression change does not identify a direct silicon receptor.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A bone-development signal increased after exposure.
    primary_references
    Biological Silicon Stimulates Collagen Type 1 and Osteocalcin Synthesis in Human Osteoblast-Like Cells Through the BMP-2/Smad/RUNX2 Signaling Pathway. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27025722/ · DOI 10.1007/s12011-016-0686-3

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 144–150

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human MG-63/U2-OS cell program. · source_derived_draft · unverified_draft

    ## silica-bmp-expression A bone-development signal increased after exposure. Ten micromolar orthosilicic acid increased BMP2 expression in human osteoblast-like cells. Model: Human MG-63/U2-OS cell program. Limitations: Expression change does not identify a direct silicon receptor. Evidence access: Primary abstract Biological Silicon Stimulates Collagen Type 1 and Osteocalcin Synthesis in Human Osteoblast-Like Cells Through the BMP-2/Smad/RUNX2 Signaling Pathway. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27025722/ · DOI 10.1007/s12011-016-0686-3
    Complete structured claim and evidence

  4. Orthosilicic acid at 10–20 micromolar increased type I collagen synthesis in human osteoblast-like cultures.

    Orthosilicic acid / Si(OH)4 → Human type I collagen source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    MG-63, HCC1 and primary human marrow-derived osteoblast-like cells.
    limitations
    Cell-culture synthesis is not demonstrated human bone strength or fracture benefit.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    Bone-forming cells produced more collagen scaffold.
    primary_references
    Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12633784/ · DOI 10.1016/s8756-3282(02)00950-x

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 120–126

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · MG-63, HCC1 and primary human marrow-derived osteoblast-like cells. · source_derived_draft · unverified_draft

    ## silica-collagen-production Bone-forming cells produced more collagen scaffold. Orthosilicic acid at 10–20 micromolar increased type I collagen synthesis in human osteoblast-like cultures. Model: MG-63, HCC1 and primary human marrow-derived osteoblast-like cells. Limitations: Cell-culture synthesis is not demonstrated human bone strength or fracture benefit. Evidence access: Primary abstract Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12633784/ · DOI 10.1016/s8756-3282(02)00950-x
    Complete structured claim and evidence

  5. Type I collagen mRNA did not increase despite greater collagen synthesis in treated MG-63 cells.

    Orthosilicic acid / Si(OH)4 → Type I collagen mRNA in human MG-63 cells source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human osteosarcoma-derived MG-63 cells.
    limitations
    Translation, processing and turnover were not all separately resolved.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    The measured effect was not simply more collagen-gene transcription.
    primary_references
    Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12633784/ · DOI 10.1016/s8756-3282(02)00950-x

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 128–134

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human osteosarcoma-derived MG-63 cells. · source_derived_draft · unverified_draft

    ## silica-collagen-transcript-null The measured effect was not simply more collagen-gene transcription. Type I collagen mRNA did not increase despite greater collagen synthesis in treated MG-63 cells. Model: Human osteosarcoma-derived MG-63 cells. Limitations: Translation, processing and turnover were not all separately resolved. Evidence access: Primary abstract Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12633784/ · DOI 10.1016/s8756-3282(02)00950-x
    Complete structured claim and evidence

  6. Thirty micromolar OSA improved HUVEC proliferation, migration and tube formation under high glucose.

    Orthosilicic acid / Si(OH)4 → HUVEC function under high glucose source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human HUVEC high-glucose model.
    limitations
    Clinical diabetic wound efficacy is unestablished; accessed abstract lacks full dose-response and inhibitor details.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A recent study tested an additional stress context.
    primary_references
    Orthosilicic Acid Promotes Diabetic Wound Healing Through the PI3 K/AKT/mTOR Signaling Pathway. · 2026 · https://pubmed.ncbi.nlm.nih.gov/40517214/ · DOI 10.1007/s12011-025-04670-6

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 336–342

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human HUVEC high-glucose model. · source_derived_draft · unverified_draft

    ## silica-diabetic-endothelium A recent study tested an additional stress context. Thirty micromolar OSA improved HUVEC proliferation, migration and tube formation under high glucose. Model: Human HUVEC high-glucose model. Limitations: Clinical diabetic wound efficacy is unestablished; accessed abstract lacks full dose-response and inhibitor details. Evidence access: Primary abstract Orthosilicic Acid Promotes Diabetic Wound Healing Through the PI3 K/AKT/mTOR Signaling Pathway. · 2026 · https://pubmed.ncbi.nlm.nih.gov/40517214/ · DOI 10.1007/s12011-025-04670-6
    Complete structured claim and evidence

  7. OSA improved skin-wound healing in db/db mice, with PI3K/Akt/mTOR involvement reported.

    Orthosilicic acid / Si(OH)4 → Wound healing in db/db mice source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Diabetic db/db mice; primary abstract.
    limitations
    Route, formulation and complete mediation experiments require full-text follow-up; not human treatment evidence.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    The research included an animal wound outcome.
    primary_references
    Orthosilicic Acid Promotes Diabetic Wound Healing Through the PI3 K/AKT/mTOR Signaling Pathway. · 2026 · https://pubmed.ncbi.nlm.nih.gov/40517214/ · DOI 10.1007/s12011-025-04670-6

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 344–350

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Diabetic db/db mice; primary abstract. · source_derived_draft · unverified_draft

    ## silica-diabetic-mouse-wound The research included an animal wound outcome. OSA improved skin-wound healing in db/db mice, with PI3K/Akt/mTOR involvement reported. Model: Diabetic db/db mice; primary abstract. Limitations: Route, formulation and complete mediation experiments require full-text follow-up; not human treatment evidence. Evidence access: Primary abstract Orthosilicic Acid Promotes Diabetic Wound Healing Through the PI3 K/AKT/mTOR Signaling Pathway. · 2026 · https://pubmed.ncbi.nlm.nih.gov/40517214/ · DOI 10.1007/s12011-025-04670-6
    Complete structured claim and evidence

  8. Orthosilicic acid increased miR-146a during later osteogenic differentiation of human mesenchymal stromal cells.

    Orthosilicic acid / Si(OH)4 → Human miR-146a source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human MSC microarray and qPCR experiments.
    limitations
    Late-stage association is distinct from identification of the upstream silicon sensor.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A regulatory RNA connects exposure to cell-state change.
    primary_references
    Orthosilicic acid, Si(OH)4, stimulates osteoblast differentiation in vitro by upregulating miR-146a to antagonize NF-κB activation. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27163405/ · DOI 10.1016/j.actbio.2016.05.007

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 184–190

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human MSC microarray and qPCR experiments. · source_derived_draft · unverified_draft

    ## silica-mir146a A regulatory RNA connects exposure to cell-state change. Orthosilicic acid increased miR-146a during later osteogenic differentiation of human mesenchymal stromal cells. Model: Human MSC microarray and qPCR experiments. Limitations: Late-stage association is distinct from identification of the upstream silicon sensor. Evidence access: Primary abstract Orthosilicic acid, Si(OH)4, stimulates osteoblast differentiation in vitro by upregulating miR-146a to antagonize NF-κB activation. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27163405/ · DOI 10.1016/j.actbio.2016.05.007
    Complete structured claim and evidence

  9. The monomeric preparation did not significantly reduce aluminum availability in the same study.

    Orthosilicic acid / Si(OH)4 → Aluminum(III) source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Same three-person human tracer experiment.
    limitations
    Chemical-form difference is not a scientific contradiction.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    Soluble monomers and oligomers do not behave identically.
    primary_references
    Oligomeric but not monomeric silica prevents aluminum absorption in humans. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10731501/ · DOI 10.1093/ajcn/71.4.944

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 96–102

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Same three-person human tracer experiment. · source_derived_draft · unverified_draft

    ## silica-monomer-aluminum-null Soluble monomers and oligomers do not behave identically. The monomeric preparation did not significantly reduce aluminum availability in the same study. Model: Same three-person human tracer experiment. Limitations: Chemical-form difference is not a scientific contradiction. Evidence access: Primary abstract Oligomeric but not monomeric silica prevents aluminum absorption in humans. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10731501/ · DOI 10.1093/ajcn/71.4.944
    Complete structured claim and evidence

  10. Orthosilicic acid attenuated TNF-induced NF-kappaB activation in the osteoblast experimental program.

    Orthosilicic acid / Si(OH)4 → NF-kappaB activation in the 2016 silicate osteoblast study source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human MSC/mouse preosteoblast study; exact species for each downstream assay unresolved in accessed abstract.
    limitations
    Do not assign all downstream experiments to human cells or infer an oral anti-inflammatory treatment.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A regulatory-RNA response was linked to lower inflammatory signaling.
    primary_references
    Orthosilicic acid, Si(OH)4, stimulates osteoblast differentiation in vitro by upregulating miR-146a to antagonize NF-κB activation. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27163405/ · DOI 10.1016/j.actbio.2016.05.007

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 520–526

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human MSC/mouse preosteoblast study; exact species for each downstream assay unresolved in accessed abstract. · source_derived_draft · unverified_draft

    ## silica-nfkb-regulation A regulatory-RNA response was linked to lower inflammatory signaling. Orthosilicic acid attenuated TNF-induced NF-kappaB activation in the osteoblast experimental program. Model: Human MSC/mouse preosteoblast study; exact species for each downstream assay unresolved in accessed abstract. Limitations: Do not assign all downstream experiments to human cells or infer an oral anti-inflammatory treatment. Evidence access: Primary abstract Orthosilicic acid, Si(OH)4, stimulates osteoblast differentiation in vitro by upregulating miR-146a to antagonize NF-κB activation. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27163405/ · DOI 10.1016/j.actbio.2016.05.007
    Complete structured claim and evidence

  11. Median minimum uptake estimated from urine was 50.3% in eight volunteers receiving orthosilicic acid.

    Orthosilicic acid / Si(OH)4 → Human gastrointestinal uptake of soluble silicon source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Water containing 27–55 mg Si/L; small human kinetic study.
    limitations
    Urinary recovery is a lower-bound estimate, not direct intracellular measurement.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A substantial fraction of soluble silicon entered the body.
    primary_references
    Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10612067/ · DOI 10.1016/s0162-0134(99)00126-9

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 64–70

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Water containing 27–55 mg Si/L; small human kinetic study. · source_derived_draft · unverified_draft

    ## silica-oral-uptake A substantial fraction of soluble silicon entered the body. Median minimum uptake estimated from urine was 50.3% in eight volunteers receiving orthosilicic acid. Model: Water containing 27–55 mg Si/L; small human kinetic study. Limitations: Urinary recovery is a lower-bound estimate, not direct intracellular measurement. Evidence access: Primary abstract Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10612067/ · DOI 10.1016/s0162-0134(99)00126-9
    Complete structured claim and evidence

  12. At 1,700 micromolar orthosilicic acid, Saos-2 colony survival was about 20% below control, with reduced proliferation/adhesion.

    Orthosilicic acid / Si(OH)4 → Human Saos-2 colony survival source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human osteoblast-like culture comparison, up to solubility limit.
    limitations
    Different concentration and endpoints from low-dose collagen studies; not a fabricated contradiction.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    Higher exposure was not uniformly beneficial.
    primary_references
    Divergent effects of orthosilicic acid and dimethylsilanediol on cell survival and adhesion in human osteoblast-like cells. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18755397/ · DOI 10.1016/j.jtemb.2008.02.001

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 200–206

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human osteoblast-like culture comparison, up to solubility limit. · source_derived_draft · unverified_draft

    ## silica-osa-high-exposure Higher exposure was not uniformly beneficial. At 1,700 micromolar orthosilicic acid, Saos-2 colony survival was about 20% below control, with reduced proliferation/adhesion. Model: Human osteoblast-like culture comparison, up to solubility limit. Limitations: Different concentration and endpoints from low-dose collagen studies; not a fabricated contradiction. Evidence access: Primary abstract Divergent effects of orthosilicic acid and dimethylsilanediol on cell survival and adhesion in human osteoblast-like cells. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18755397/ · DOI 10.1016/j.jtemb.2008.02.001
    Complete structured claim and evidence

  13. Orthosilicic acid increased PI3K, phosphorylated Akt and mTOR together with osteogenic markers.

    Orthosilicic acid / Si(OH)4 → Human mechanistic target of rapamycin kinase / MTOR source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human osteoblast-like cell study.
    limitations
    No direct binding target or dietary requirement is established.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A growth-related pathway accompanied matrix production.
    primary_references
    Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30421162/ · DOI 10.1007/s12011-018-1574-9

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 168–174

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human osteoblast-like cell study. · source_derived_draft · unverified_draft

    ## silica-pi3k-mtor A growth-related pathway accompanied matrix production. Orthosilicic acid increased PI3K, phosphorylated Akt and mTOR together with osteogenic markers. Model: Human osteoblast-like cell study. Limitations: No direct binding target or dietary requirement is established. Evidence access: Primary abstract Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30421162/ · DOI 10.1007/s12011-018-1574-9
    Complete structured claim and evidence

  14. Reported silicon renal clearance was 82–96 mL/min and correlated with creatinine clearance.

    Orthosilicic acid / Si(OH)4 → Renal clearance of silicon in humans source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Healthy volunteer kinetics.
    limitations
    No universal tissue sufficiency threshold follows from serum or urine silicon.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    Kidney function affects measured silicon handling.
    primary_references
    Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10612067/ · DOI 10.1016/s0162-0134(99)00126-9

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 72–78

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Healthy volunteer kinetics. · source_derived_draft · unverified_draft

    ## silica-renal-clearance Kidney function affects measured silicon handling. Reported silicon renal clearance was 82–96 mL/min and correlated with creatinine clearance. Model: Healthy volunteer kinetics. Limitations: No universal tissue sufficiency threshold follows from serum or urine silicon. Evidence access: Primary abstract Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10612067/ · DOI 10.1016/s0162-0134(99)00126-9
    Complete structured claim and evidence

  15. Orthosilicic acid increased phosphorylated SMAD1/5 and RUNX2 expression alongside osteogenic markers.

    Orthosilicic acid / Si(OH)4 → Human SMAD1/SMAD5 signaling proteins source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human osteoblast-like cell lines, 10 micromolar exposure.
    limitations
    Marker regulation does not prove each edge by direct binding.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    The response extended to downstream bone-development regulators.
    primary_references
    Biological Silicon Stimulates Collagen Type 1 and Osteocalcin Synthesis in Human Osteoblast-Like Cells Through the BMP-2/Smad/RUNX2 Signaling Pathway. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27025722/ · DOI 10.1007/s12011-016-0686-3

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 152–158

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human osteoblast-like cell lines, 10 micromolar exposure. · source_derived_draft · unverified_draft

    ## silica-smad-runx2 The response extended to downstream bone-development regulators. Orthosilicic acid increased phosphorylated SMAD1/5 and RUNX2 expression alongside osteogenic markers. Model: Human osteoblast-like cell lines, 10 micromolar exposure. Limitations: Marker regulation does not prove each edge by direct binding. Evidence access: Primary abstract Biological Silicon Stimulates Collagen Type 1 and Osteocalcin Synthesis in Human Osteoblast-Like Cells Through the BMP-2/Smad/RUNX2 Signaling Pathway. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27025722/ · DOI 10.1007/s12011-016-0686-3
    Complete structured claim and evidence

What acts on it

  1. Expression of human AQP10 increased silicon transport in the tested oocyte and HEK-293 systems.

    Human aquaporin 10 / AQP10 → Orthosilicic acid / Si(OH)4 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Human constructs in Xenopus oocytes and human HEK-293 cells.
    limitations
    Expression-system flux does not establish the dominant transporter in every human tissue.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    AQP10 provides a separately identifiable route for soluble silicon.
    primary_references
    Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149
    transport_effect
    raises Expression increased silicon transport in the oocyte and HEK-293 uptake systems.
    transport_pool
    the expressing cell Expression increased silicon transport in the oocyte and HEK-293 uptake systems.

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 40–46

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human constructs in Xenopus oocytes and human HEK-293 cells. · source_derived_draft · unverified_draft

    ## silica-aqp10-transport AQP10 provides a separately identifiable route for soluble silicon. Expression of human AQP10 increased silicon transport in the tested oocyte and HEK-293 systems. Model: Human constructs in Xenopus oocytes and human HEK-293 cells. Limitations: Expression-system flux does not establish the dominant transporter in every human tissue. Evidence access: Primary full text Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149
    Complete structured claim and evidence

  2. Expression of human AQP3 increased silicon transport in the tested oocyte and HEK-293 systems.

    Human aquaporin 3 / AQP3 → Orthosilicic acid / Si(OH)4 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Human constructs in Xenopus oocytes and human HEK-293 cells.
    limitations
    Expression-system flux does not establish the dominant transporter in every human tissue.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    AQP3 provides a separately identifiable route for soluble silicon.
    primary_references
    Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149
    transport_effect
    raises Expression increased silicon transport in the oocyte and HEK-293 uptake systems.
    transport_pool
    the expressing cell Expression increased silicon transport in the oocyte and HEK-293 uptake systems.

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 16–22

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human constructs in Xenopus oocytes and human HEK-293 cells. · source_derived_draft · unverified_draft

    ## silica-aqp3-transport AQP3 provides a separately identifiable route for soluble silicon. Expression of human AQP3 increased silicon transport in the tested oocyte and HEK-293 systems. Model: Human constructs in Xenopus oocytes and human HEK-293 cells. Limitations: Expression-system flux does not establish the dominant transporter in every human tissue. Evidence access: Primary full text Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149
    Complete structured claim and evidence

  3. Expression of human AQP7 increased silicon transport in the tested oocyte and HEK-293 systems.

    Human aquaporin 7 / AQP7 → Orthosilicic acid / Si(OH)4 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Human constructs in Xenopus oocytes and human HEK-293 cells.
    limitations
    Expression-system flux does not establish the dominant transporter in every human tissue.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    AQP7 provides a separately identifiable route for soluble silicon.
    primary_references
    Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149
    transport_effect
    raises Expression increased silicon transport in the oocyte and HEK-293 uptake systems.
    transport_pool
    the expressing cell Expression increased silicon transport in the oocyte and HEK-293 uptake systems.

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 24–30

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human constructs in Xenopus oocytes and human HEK-293 cells. · source_derived_draft · unverified_draft

    ## silica-aqp7-transport AQP7 provides a separately identifiable route for soluble silicon. Expression of human AQP7 increased silicon transport in the tested oocyte and HEK-293 systems. Model: Human constructs in Xenopus oocytes and human HEK-293 cells. Limitations: Expression-system flux does not establish the dominant transporter in every human tissue. Evidence access: Primary full text Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149
    Complete structured claim and evidence

  4. Expression of human AQP9 increased silicon transport in the tested oocyte and HEK-293 systems.

    Human aquaporin 9 / AQP9 → Orthosilicic acid / Si(OH)4 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Human constructs in Xenopus oocytes and human HEK-293 cells.
    limitations
    Expression-system flux does not establish the dominant transporter in every human tissue.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    AQP9 provides a separately identifiable route for soluble silicon.
    primary_references
    Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149
    transport_effect
    raises Expression increased silicon transport in the oocyte and HEK-293 uptake systems.
    transport_pool
    the expressing cell Expression increased silicon transport in the oocyte and HEK-293 uptake systems.

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 32–38

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human constructs in Xenopus oocytes and human HEK-293 cells. · source_derived_draft · unverified_draft

    ## silica-aqp9-transport AQP9 provides a separately identifiable route for soluble silicon. Expression of human AQP9 increased silicon transport in the tested oocyte and HEK-293 systems. Model: Human constructs in Xenopus oocytes and human HEK-293 cells. Limitations: Expression-system flux does not establish the dominant transporter in every human tissue. Evidence access: Primary full text Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Combined AQP3/AQP7/AQP9/AQP10 RNA interference reduced silicon efflux from preloaded HEK-293 cells.

    Combined human aquaglyceroporin silencing → Silicon efflux from human HEK-293 cells source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Human HEK-293 cells, 2 mM loading and brief efflux assay.
    limitations
    Combined knockdown does not quantify each channel’s independent in-vivo contribution.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    Loss of transport machinery changes silicon movement.
    primary_references
    Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 48–54

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human HEK-293 cells, 2 mM loading and brief efflux assay. · source_derived_draft · unverified_draft

    ## silica-aqp-silencing Loss of transport machinery changes silicon movement. Combined AQP3/AQP7/AQP9/AQP10 RNA interference reduced silicon efflux from preloaded HEK-293 cells. Model: Human HEK-293 cells, 2 mM loading and brief efflux assay. Limitations: Combined knockdown does not quantify each channel’s independent in-vivo contribution. Evidence access: Primary full text Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149
    Complete structured claim and evidence

  2. Phloretin increased AQP9-mediated silicon influx under the tested hypoosmolar conditions while inhibiting water transport.

    Phloretin → Human aquaporin 9 / AQP9 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Human AQP9 in Xenopus oocytes; 0.1 mM phloretin, 2 mM silicic acid.
    limitations
    Not a demonstrated food interaction; the abstract’s phloretin-sensitive wording does not mean silicon flux was inhibited.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A transport inhibitor can affect two substrates differently.
    primary_references
    Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 56–62

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human AQP9 in Xenopus oocytes; 0.1 mM phloretin, 2 mM silicic acid. · source_derived_draft · unverified_draft

    ## silica-aqp9-phloretin A transport inhibitor can affect two substrates differently. Phloretin increased AQP9-mediated silicon influx under the tested hypoosmolar conditions while inhibiting water transport. Model: Human AQP9 in Xenopus oocytes; 0.1 mM phloretin, 2 mM silicic acid. Limitations: Not a demonstrated food interaction; the abstract’s phloretin-sensitive wording does not mean silicon flux was inhibited. Evidence access: Primary full text Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149
    Complete structured claim and evidence

  3. Dimethylsilanediol had no discernible survival effect up to 50 micromolar and increased survival at higher tested doses.

    Dimethylsilanediol → Human Saos-2 colony survival source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human osteoblast-like cell comparison.
    limitations
    Environmental silicone degradation product, not evidence that silicone polymers or supplements share this activity.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    An organosilicon compound produced a different cellular response.
    primary_references
    Divergent effects of orthosilicic acid and dimethylsilanediol on cell survival and adhesion in human osteoblast-like cells. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18755397/ · DOI 10.1016/j.jtemb.2008.02.001

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 208–214

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human osteoblast-like cell comparison. · source_derived_draft · unverified_draft

    ## silica-dimethyl-form An organosilicon compound produced a different cellular response. Dimethylsilanediol had no discernible survival effect up to 50 micromolar and increased survival at higher tested doses. Model: Human osteoblast-like cell comparison. Limitations: Environmental silicone degradation product, not evidence that silicone polymers or supplements share this activity. Evidence access: Primary abstract Divergent effects of orthosilicic acid and dimethylsilanediol on cell survival and adhesion in human osteoblast-like cells. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18755397/ · DOI 10.1016/j.jtemb.2008.02.001
    Complete structured claim and evidence

  4. Urinary recovery was approximately 43% for orthosilicic acid, 17% for choline-stabilized acid and 1% for colloidal silica in this comparison.

    Choline-stabilized orthosilicic acid → Urinary silicon recovery after oral preparations source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Small crossover comparisons; colloidal silica n=3, other sources at least five.
    limitations
    Different preparations and dissolution; not proof that choline itself suppresses absorption or defines a cofactor.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    The same elemental amount need not deliver the same soluble exposure.
    primary_references
    The comparative absorption of silicon from different foods and food supplements. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19356271/ · DOI 10.1017/S0007114509311757

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 80–86

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Small crossover comparisons; colloidal silica n=3, other sources at least five. · source_derived_draft · unverified_draft

    ## silica-formulation-absorption The same elemental amount need not deliver the same soluble exposure. Urinary recovery was approximately 43% for orthosilicic acid, 17% for choline-stabilized acid and 1% for colloidal silica in this comparison. Model: Small crossover comparisons; colloidal silica n=3, other sources at least five. Limitations: Different preparations and dissolution; not proof that choline itself suppresses absorption or defines a cofactor. Evidence access: Primary abstract The comparative absorption of silicon from different foods and food supplements. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19356271/ · DOI 10.1017/S0007114509311757
    Complete structured claim and evidence

  5. Prolyl hydroxylase inhibitors abolished the orthosilicic-acid-associated collagen increase.

    Prolyl hydroxylase inhibition in human osteoblast-like cells → Collagen synthesis response to orthosilicic acid source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Human osteoblast-like cell inhibitor study.
    limitations
    Does not prove direct silicon binding or silicon as an obligatory enzyme cofactor.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    Intact collagen-processing machinery was needed for the response.
    primary_references
    Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12633784/ · DOI 10.1016/s8756-3282(02)00950-x
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 136–142

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human osteoblast-like cell inhibitor study. · source_derived_draft · unverified_draft

    ## silica-hydroxylase-block Intact collagen-processing machinery was needed for the response. Prolyl hydroxylase inhibitors abolished the orthosilicic-acid-associated collagen increase. Model: Human osteoblast-like cell inhibitor study. Limitations: Does not prove direct silicon binding or silicon as an obligatory enzyme cofactor. Evidence access: Primary abstract Orthosilicic acid stimulates collagen type 1 synthesis and osteoblastic differentiation in human osteoblast-like cells in vitro. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12633784/ · DOI 10.1016/s8756-3282(02)00950-x
    Complete structured claim and evidence

  6. LY294002 reduced pathway signals and osteogenic markers during orthosilicic acid treatment.

    LY294002 treatment of human osteoblast-like cells → Collagen synthesis response to orthosilicic acid source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Human osteoblast-like cultures.
    limitations
    LY294002 has off-target effects and is not an inhibitor specific to the entire PI3K–Akt–mTOR chain.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    The cell response was sensitive to PI3K-pathway blockade.
    primary_references
    Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30421162/ · DOI 10.1007/s12011-018-1574-9
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 176–182

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human osteoblast-like cultures. · source_derived_draft · unverified_draft

    ## silica-ly294002-block The cell response was sensitive to PI3K-pathway blockade. LY294002 reduced pathway signals and osteogenic markers during orthosilicic acid treatment. Model: Human osteoblast-like cultures. Limitations: LY294002 has off-target effects and is not an inhibitor specific to the entire PI3K–Akt–mTOR chain. Evidence access: Primary abstract Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30421162/ · DOI 10.1007/s12011-018-1574-9
    Complete structured claim and evidence

  7. Anti-miR-146a suppressed differentiation in MC3T3 preosteoblasts in the silicate study.

    Anti-miR-146a treatment in mouse MC3T3 cells → Mouse osteoblast differentiation source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Mouse MC3T3 cells; distinguish from the human MSC discovery assay.
    limitations
    Abstract does not resolve all species-specific downstream targets.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    Removing a regulatory RNA weakened bone-cell maturation.
    primary_references
    Orthosilicic acid, Si(OH)4, stimulates osteoblast differentiation in vitro by upregulating miR-146a to antagonize NF-κB activation. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27163405/ · DOI 10.1016/j.actbio.2016.05.007
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 192–198

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse MC3T3 cells; distinguish from the human MSC discovery assay. · source_derived_draft · unverified_draft

    ## silica-mouse-antimir Removing a regulatory RNA weakened bone-cell maturation. Anti-miR-146a suppressed differentiation in MC3T3 preosteoblasts in the silicate study. Model: Mouse MC3T3 cells; distinguish from the human MSC discovery assay. Limitations: Abstract does not resolve all species-specific downstream targets. Evidence access: Primary abstract Orthosilicic acid, Si(OH)4, stimulates osteoblast differentiation in vitro by upregulating miR-146a to antagonize NF-κB activation. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27163405/ · DOI 10.1016/j.actbio.2016.05.007
    Complete structured claim and evidence

  8. Noggin pretreatment suppressed silicon-associated SMAD1/5 phosphorylation, RUNX2 and collagen expression.

    Noggin-treated human osteoblast-like cultures → Collagen synthesis response to orthosilicic acid source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Human osteoblast-like cell pharmacological experiment.
    limitations
    Noggin is a BMP antagonist, not a uniquely selective proof of BMP2 mediation.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    Blocking BMP signaling weakened the response.
    primary_references
    Biological Silicon Stimulates Collagen Type 1 and Osteocalcin Synthesis in Human Osteoblast-Like Cells Through the BMP-2/Smad/RUNX2 Signaling Pathway. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27025722/ · DOI 10.1007/s12011-016-0686-3
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 160–166

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human osteoblast-like cell pharmacological experiment. · source_derived_draft · unverified_draft

    ## silica-noggin-block Blocking BMP signaling weakened the response. Noggin pretreatment suppressed silicon-associated SMAD1/5 phosphorylation, RUNX2 and collagen expression. Model: Human osteoblast-like cell pharmacological experiment. Limitations: Noggin is a BMP antagonist, not a uniquely selective proof of BMP2 mediation. Evidence access: Primary abstract Biological Silicon Stimulates Collagen Type 1 and Osteocalcin Synthesis in Human Osteoblast-Like Cells Through the BMP-2/Smad/RUNX2 Signaling Pathway. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27025722/ · DOI 10.1007/s12011-016-0686-3
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards