{"id":"08dac278-dda3-5fb4-bf32-71d5f60f9c84","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-noggin-block","predicate":"reduces","statement":"Noggin pretreatment suppressed silicon-associated SMAD1/5 phosphorylation, RUNX2 and collagen expression.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b7537d93-56b4-563e-b1f5-3cb5fe44d9cd","mechanism_event_label":"Blocking BMP signaling weakened the response.","subject":{"id":"d99b14a3-9d62-551d-bc13-2f4a569692d5","slug":"human-noggin-treated-osteoblasts","display_name":"Noggin-treated human osteoblast-like cultures","entity_type_key":"cellular_process"},"object":{"id":"8a31fdbb-3012-50f8-8be2-1c5b373aa5c7","slug":"human-osa-collagen-response","display_name":"Collagen synthesis response to orthosilicic acid","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b7537d93-56b4-563e-b1f5-3cb5fe44d9cd","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-noggin-block-event","event_type":"observed_relationship","label":"Blocking BMP signaling weakened the response.","description":"Noggin pretreatment suppressed silicon-associated SMAD1/5 phosphorylation, RUNX2 and collagen expression.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d99b14a3-9d62-551d-bc13-2f4a569692d5","slug":"human-noggin-treated-osteoblasts","display_name":"Noggin-treated human osteoblast-like cultures","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8a31fdbb-3012-50f8-8be2-1c5b373aa5c7","slug":"human-osa-collagen-response","display_name":"Collagen synthesis response to orthosilicic acid","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"c497144d-1e90-5176-a475-2d715992f5b0","slug":"orthosilicic-acid","display_name":"Orthosilicic acid / Si(OH)4","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"a2b4dc1b-5982-501a-836a-00692b9fddea","slug":"human-bmp2","display_name":"Human BMP2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"6c60fb69-a346-5608-938d-da09b08ff170","slug":"human-smad1-smad5","display_name":"Human SMAD1/SMAD5 signaling proteins","entity_type_key":"protein_family"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""},{"entity":{"id":"30dd8e5f-7abe-5fd5-927d-e8204e5de6e5","slug":"runx2","display_name":"RUNX2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":6,"notes":""},{"entity":{"id":"091a1ec0-5867-5659-b199-b73a1ac8b9c6","slug":"human-type-i-collagen","display_name":"Human type I collagen","entity_type_key":"protein_complex"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":7,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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