{"id":"15e482a8-b333-577f-b71c-5c0182a32689","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-aluminum-urine-null","predicate":"does_not_increase","statement":"Orthosilicic acid in water did not significantly increase endogenous aluminum excretion over 32 hours in five volunteers.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"342cb534-5d55-53b2-a6ee-15914d3b8dde","mechanism_event_label":"A separate human study did not reproduce increased aluminum clearance.","subject":{"id":"c497144d-1e90-5176-a475-2d715992f5b0","slug":"orthosilicic-acid","display_name":"Orthosilicic acid / Si(OH)4","entity_type_key":"small_molecule"},"object":{"id":"b9f2d512-7ff3-5d1c-9ae6-547c9aa6385f","slug":"human-urinary-aluminum-excretion","display_name":"Human urinary aluminum excretion","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"342cb534-5d55-53b2-a6ee-15914d3b8dde","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-aluminum-urine-null-event","event_type":"observed_relationship","label":"A separate human study did not reproduce increased aluminum clearance.","description":"Orthosilicic acid in water did not significantly increase endogenous aluminum excretion over 32 hours in five volunteers.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c497144d-1e90-5176-a475-2d715992f5b0","slug":"orthosilicic-acid","display_name":"Orthosilicic acid / Si(OH)4","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"b9f2d512-7ff3-5d1c-9ae6-547c9aa6385f","slug":"human-urinary-aluminum-excretion","display_name":"Human urinary aluminum excretion","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"88d3484c-e93c-56ea-bc7d-545559b4c82e","slug":"aluminum-iii","display_name":"Aluminum(III)","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Water dosing, small human kinetic study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different matrix, baseline aluminum and timing may matter; urinary output is not a measurement of brain aluminum.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A separate human study did not reproduce increased aluminum clearance.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10612067/ · DOI 10.1016/s0162-0134(99)00126-9","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c366aa1e-e30c-5c89-be86-a71867f5263d","evidence_kind":"source_excerpt","locator":"Lines 112-118","start_line":112,"end_line":118,"excerpt":"## silica-aluminum-urine-null\nA separate human study did not reproduce increased aluminum clearance.\nOrthosilicic acid in water did not significantly increase endogenous aluminum excretion over 32 hours in five volunteers.\nModel: Water dosing, small human kinetic study.\nLimitations: Different matrix, baseline aluminum and timing may matter; urinary output is not a measurement of brain aluminum.\nEvidence access: Primary abstract\nSilicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10612067/ · DOI 10.1016/s0162-0134(99)00126-9","model_system":"Water dosing, small human kinetic study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc4b461e-dd46-57ab-8213-8aeb7ff9e8d0","stable_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"e05d81962a1ca6cbfc68fce4fd3dbcdea67c8e61332c19f4fec5d0c3ab8bf1b9","revision_id":"6433ed49-a331-571b-a611-21e56c3ce4bc","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[{"id":"a64ac7f8-54ac-597e-aee9-cab01db3cb97","title":"Does oral monosilicic acid increase urinary aluminum excretion?","kind":"contradiction","status":"open","why":"An earlier human study reports increased urinary aluminum and proposes reduced renal reabsorption; a subsequent water-dosing study reports no significant increase. The disagreement concerns reproducibility of enhanced elimination, not the separately established difference between monomeric and oligomeric intestinal binding.","resolution":"Compare beverage constituents, actual silicon species, aluminum exposure, baseline body burden, renal function, collection interval and statistical precision. A direct renal complex or transporter mechanism remains unproven; neither study demonstrates brain aluminum removal.","created_at":"2026-09-19 14:07:52","record_type":"conflict","display_label":"Recorded conflict","record_url":"/conflicts/a64ac7f8-54ac-597e-aee9-cab01db3cb97","sides":[{"conflict_id":"a64ac7f8-54ac-597e-aee9-cab01db3cb97","ordinal":0,"label":"Earlier increased excretion","revision_id":"6433ed49-a331-571b-a611-21e56c3ce4bc","start_line":104,"end_line":110,"quote":"## silica-aluminum-urine-positive\nA renal effect was proposed in addition to intestinal binding.\nBeer-derived monosilicic acid ingestion was accompanied by increased urinary aluminum in this study.\nModel: Healthy volunteers; beverage matrix and isotope experiments.\nLimitations: Kidney-lumen complex formation and reduced reabsorption were proposed, not directly established molecular targets.\nEvidence access: Primary abstract\nThe role of silicic acid in the renal excretion of aluminium. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8726215/","source_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","source_title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","claim_ids":["3186242a-7de4-5ec6-a61a-fabfb796dc17"]},{"conflict_id":"a64ac7f8-54ac-597e-aee9-cab01db3cb97","ordinal":1,"label":"Later null excretion result","revision_id":"6433ed49-a331-571b-a611-21e56c3ce4bc","start_line":112,"end_line":118,"quote":"## silica-aluminum-urine-null\nA separate human study did not reproduce increased aluminum clearance.\nOrthosilicic acid in water did not significantly increase endogenous aluminum excretion over 32 hours in five volunteers.\nModel: Water dosing, small human kinetic study.\nLimitations: Different matrix, baseline aluminum and timing may matter; urinary output is not a measurement of brain aluminum.\nEvidence access: Primary abstract\nSilicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10612067/ · DOI 10.1016/s0162-0134(99)00126-9","source_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","source_title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","claim_ids":["15e482a8-b333-577f-b71c-5c0182a32689"]}]}],"corrections":[],"research":null}