Component
Human miR-146a
Context-specific entity; species, compartment and exposure are stated on each claim.
2 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Orthosilicic acid increased miR-146a during later osteogenic differentiation of human mesenchymal stromal cells.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human MSC microarray and qPCR experiments.
- limitations
- Late-stage association is distinct from identification of the upstream silicon sensor.
- nutrient_topic
- Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
- plain_language
- A regulatory RNA connects exposure to cell-state change.
- primary_references
- Orthosilicic acid, Si(OH)4, stimulates osteoblast differentiation in vitro by upregulating miR-146a to antagonize NF-κB activation. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27163405/ · DOI 10.1016/j.actbio.2016.05.007
Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 184–190
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human MSC microarray and qPCR experiments. · source_derived_draft · unverified_draft
## silica-mir146a A regulatory RNA connects exposure to cell-state change. Orthosilicic acid increased miR-146a during later osteogenic differentiation of human mesenchymal stromal cells. Model: Human MSC microarray and qPCR experiments. Limitations: Late-stage association is distinct from identification of the upstream silicon sensor. Evidence access: Primary abstract Orthosilicic acid, Si(OH)4, stimulates osteoblast differentiation in vitro by upregulating miR-146a to antagonize NF-κB activation. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27163405/ · DOI 10.1016/j.actbio.2016.05.007
Complete structured claim and evidence
Where it participates (unsigned role)
Orthosilicic acid attenuated TNF-induced NF-kappaB activation in the osteoblast experimental program.
Experimental context and source evidence
- evidence_access
- Primary abstract
- experimental_model
- Human MSC/mouse preosteoblast study; exact species for each downstream assay unresolved in accessed abstract.
- limitations
- Do not assign all downstream experiments to human cells or infer an oral anti-inflammatory treatment.
- nutrient_topic
- Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
- plain_language
- A regulatory-RNA response was linked to lower inflammatory signaling.
- primary_references
- Orthosilicic acid, Si(OH)4, stimulates osteoblast differentiation in vitro by upregulating miR-146a to antagonize NF-κB activation. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27163405/ · DOI 10.1016/j.actbio.2016.05.007
Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 520–526
AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human MSC/mouse preosteoblast study; exact species for each downstream assay unresolved in accessed abstract. · source_derived_draft · unverified_draft
## silica-nfkb-regulation A regulatory-RNA response was linked to lower inflammatory signaling. Orthosilicic acid attenuated TNF-induced NF-kappaB activation in the osteoblast experimental program. Model: Human MSC/mouse preosteoblast study; exact species for each downstream assay unresolved in accessed abstract. Limitations: Do not assign all downstream experiments to human cells or infer an oral anti-inflammatory treatment. Evidence access: Primary abstract Orthosilicic acid, Si(OH)4, stimulates osteoblast differentiation in vitro by upregulating miR-146a to antagonize NF-κB activation. · 2016 · https://pubmed.ncbi.nlm.nih.gov/27163405/ · DOI 10.1016/j.actbio.2016.05.007
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.