{"id":"2e548725-12f4-5c2a-a1f6-abd7f0c44a80","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-diabetic-endothelium","predicate":"improves","statement":"Thirty micromolar OSA improved HUVEC proliferation, migration and tube formation under high glucose.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"18919407-a52a-540b-8c99-15a079235313","mechanism_event_label":"A recent study tested an additional stress context.","subject":{"id":"c497144d-1e90-5176-a475-2d715992f5b0","slug":"orthosilicic-acid","display_name":"Orthosilicic acid / Si(OH)4","entity_type_key":"small_molecule"},"object":{"id":"ccc4afd9-1242-5b68-b33a-c56fe5cbf84b","slug":"human-high-glucose-endothelial-function","display_name":"HUVEC function under high glucose","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"18919407-a52a-540b-8c99-15a079235313","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-diabetic-endothelium-event","event_type":"observed_relationship","label":"A recent study tested an additional stress context.","description":"Thirty micromolar OSA improved HUVEC proliferation, migration and tube formation under high glucose.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c497144d-1e90-5176-a475-2d715992f5b0","slug":"orthosilicic-acid","display_name":"Orthosilicic acid / Si(OH)4","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"ccc4afd9-1242-5b68-b33a-c56fe5cbf84b","slug":"human-high-glucose-endothelial-function","display_name":"HUVEC function under high glucose","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human HUVEC high-glucose model.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Clinical diabetic wound efficacy is unestablished; accessed abstract lacks full dose-response and inhibitor details.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A recent study tested an additional stress context.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Orthosilicic Acid Promotes Diabetic Wound Healing Through the PI3 K/AKT/mTOR Signaling Pathway. · 2026 · https://pubmed.ncbi.nlm.nih.gov/40517214/ · DOI 10.1007/s12011-025-04670-6","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"303928c0-6f2d-5cb1-9bca-d1b8c172800a","evidence_kind":"source_excerpt","locator":"Lines 336-342","start_line":336,"end_line":342,"excerpt":"## silica-diabetic-endothelium\nA recent study tested an additional stress context.\nThirty micromolar OSA improved HUVEC proliferation, migration and tube formation under high glucose.\nModel: Human HUVEC high-glucose model.\nLimitations: Clinical diabetic wound efficacy is unestablished; accessed abstract lacks full dose-response and inhibitor details.\nEvidence access: Primary abstract\nOrthosilicic Acid Promotes Diabetic Wound Healing Through the PI3 K/AKT/mTOR Signaling Pathway. · 2026 · https://pubmed.ncbi.nlm.nih.gov/40517214/ · DOI 10.1007/s12011-025-04670-6","model_system":"Human HUVEC high-glucose model.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc4b461e-dd46-57ab-8213-8aeb7ff9e8d0","stable_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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