Component

Choline-stabilized orthosilicic acid

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Urinary recovery was approximately 43% for orthosilicic acid, 17% for choline-stabilized acid and 1% for colloidal silica in this comparison.

    Choline-stabilized orthosilicic acid → Urinary silicon recovery after oral preparations source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Small crossover comparisons; colloidal silica n=3, other sources at least five.
    limitations
    Different preparations and dissolution; not proof that choline itself suppresses absorption or defines a cofactor.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    The same elemental amount need not deliver the same soluble exposure.
    primary_references
    The comparative absorption of silicon from different foods and food supplements. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19356271/ · DOI 10.1017/S0007114509311757

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 80–86

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Small crossover comparisons; colloidal silica n=3, other sources at least five. · source_derived_draft · unverified_draft

    ## silica-formulation-absorption The same elemental amount need not deliver the same soluble exposure. Urinary recovery was approximately 43% for orthosilicic acid, 17% for choline-stabilized acid and 1% for colloidal silica in this comparison. Model: Small crossover comparisons; colloidal silica n=3, other sources at least five. Limitations: Different preparations and dissolution; not proof that choline itself suppresses absorption or defines a cofactor. Evidence access: Primary abstract The comparative absorption of silicon from different foods and food supplements. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19356271/ · DOI 10.1017/S0007114509311757
    Complete structured claim and evidence

  2. Lumbar spine BMD did not significantly change; a femoral-neck signal arose in a post-hoc subgroup.

    Choline-stabilized orthosilicic acid → Lumbar spine BMD during choline-stabilized OSA trial source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Same 12-month calcium/D3-background trial.
    limitations
    Post-hoc subgroup findings are exploratory; not independent replication.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A matrix marker and bone-density outcome did not provide equivalent evidence.
    primary_references
    Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18547426/ · DOI 10.1186/1471-2474-9-85

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 384–390

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Same 12-month calcium/D3-background trial. · source_derived_draft · unverified_draft

    ## silica-human-bmd-null A matrix marker and bone-density outcome did not provide equivalent evidence. Lumbar spine BMD did not significantly change; a femoral-neck signal arose in a post-hoc subgroup. Model: Same 12-month calcium/D3-background trial. Limitations: Post-hoc subgroup findings are exploratory; not independent replication. Evidence access: Primary abstract Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18547426/ · DOI 10.1186/1471-2474-9-85
    Complete structured claim and evidence

  3. PINP differed from placebo at 12 months in the 6- and 12-mg Si groups without a clear dose response.

    Choline-stabilized orthosilicic acid → Serum PINP during choline-stabilized OSA trial source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    184 women randomized; 136 completed; all received 1,000 mg calcium and 20 micrograms D3 daily.
    limitations
    Marker result is not fracture prevention; attrition and multiple endpoints matter.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A collagen-formation marker changed on top of calcium and vitamin D.
    primary_references
    Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18547426/ · DOI 10.1186/1471-2474-9-85

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 376–382

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · 184 women randomized; 136 completed; all received 1,000 mg calcium and 20 micrograms D3 daily. · source_derived_draft · unverified_draft

    ## silica-human-pinp A collagen-formation marker changed on top of calcium and vitamin D. PINP differed from placebo at 12 months in the 6- and 12-mg Si groups without a clear dose response. Model: 184 women randomized; 136 completed; all received 1,000 mg calcium and 20 micrograms D3 daily. Limitations: Marker result is not fracture prevention; attrition and multiple endpoints matter. Evidence access: Primary abstract Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18547426/ · DOI 10.1186/1471-2474-9-85
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards