{"id":"85c3ff79-ed57-5c81-a943-9a220fbc683f","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-human-pinp","predicate":"increases","statement":"PINP differed from placebo at 12 months in the 6- and 12-mg Si groups without a clear dose response.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"67b791e1-ace0-5db6-abe2-1543f5a052ef","mechanism_event_label":"A collagen-formation marker changed on top of calcium and vitamin D.","subject":{"id":"ffc6fc7f-212c-5bfc-a6f1-bd82c4c2b86d","slug":"choline-stabilized-orthosilicic-acid","display_name":"Choline-stabilized orthosilicic acid","entity_type_key":"chemical_species"},"object":{"id":"888e0b22-8492-5fbf-a834-4467f2fba3b3","slug":"human-chosa-pinp","display_name":"Serum PINP during choline-stabilized OSA trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"67b791e1-ace0-5db6-abe2-1543f5a052ef","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-human-pinp-event","event_type":"observed_relationship","label":"A collagen-formation marker changed on top of calcium and vitamin D.","description":"PINP differed from placebo at 12 months in the 6- and 12-mg Si groups without a clear dose response.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ffc6fc7f-212c-5bfc-a6f1-bd82c4c2b86d","slug":"choline-stabilized-orthosilicic-acid","display_name":"Choline-stabilized orthosilicic acid","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"888e0b22-8492-5fbf-a834-4467f2fba3b3","slug":"human-chosa-pinp","display_name":"Serum PINP during choline-stabilized OSA trial","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"e359bc15-e675-5d83-b0fe-1d70814e130b","slug":"calcium-ion","display_name":"Calcium ion","entity_type_key":"ion"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"b162e431-b442-5400-9335-ec91f7875a4e","slug":"cholecalciferol","display_name":"Cholecalciferol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"8e1d19fd-ad66-575d-81c4-9122f78915e5","slug":"choline","display_name":"Choline","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"184 women randomized; 136 completed; all received 1,000 mg calcium and 20 micrograms D3 daily.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Marker result is not fracture prevention; attrition and multiple endpoints matter.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A collagen-formation marker changed on top of calcium and vitamin D.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18547426/ · DOI 10.1186/1471-2474-9-85","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"ed81539d-db01-5850-88bc-04f5399f04ec","evidence_kind":"source_excerpt","locator":"Lines 376-382","start_line":376,"end_line":382,"excerpt":"## silica-human-pinp\nA collagen-formation marker changed on top of calcium and vitamin D.\nPINP differed from placebo at 12 months in the 6- and 12-mg Si groups without a clear dose response.\nModel: 184 women randomized; 136 completed; all received 1,000 mg calcium and 20 micrograms D3 daily.\nLimitations: Marker result is not fracture prevention; attrition and multiple endpoints matter.\nEvidence access: Primary abstract\nCholine-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18547426/ · DOI 10.1186/1471-2474-9-85","model_system":"184 women randomized; 136 completed; all received 1,000 mg calcium and 20 micrograms D3 daily.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc4b461e-dd46-57ab-8213-8aeb7ff9e8d0","stable_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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