{"id":"6c79d8bc-6f44-575a-a00d-7399053a338f","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-human-bmd-null","predicate":"does_not_significantly_change","statement":"Lumbar spine BMD did not significantly change; a femoral-neck signal arose in a post-hoc subgroup.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"f76724bc-a09f-5f42-af5e-d03f6538900f","mechanism_event_label":"A matrix marker and bone-density outcome did not provide equivalent evidence.","subject":{"id":"ffc6fc7f-212c-5bfc-a6f1-bd82c4c2b86d","slug":"choline-stabilized-orthosilicic-acid","display_name":"Choline-stabilized orthosilicic acid","entity_type_key":"chemical_species"},"object":{"id":"31e84bad-f378-5323-885c-59d9b60e1319","slug":"human-chosa-lumbar-bmd","display_name":"Lumbar spine BMD during choline-stabilized OSA trial","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f76724bc-a09f-5f42-af5e-d03f6538900f","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-human-bmd-null-event","event_type":"observed_relationship","label":"A matrix marker and bone-density outcome did not provide equivalent evidence.","description":"Lumbar spine BMD did not significantly change; 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not independent replication.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A matrix marker and bone-density outcome did not provide equivalent evidence.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Choline-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18547426/ · DOI 10.1186/1471-2474-9-85","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4a4b9387-d6c1-5c48-b863-1e4846c3796f","evidence_kind":"source_excerpt","locator":"Lines 384-390","start_line":384,"end_line":390,"excerpt":"## silica-human-bmd-null\nA matrix marker and bone-density outcome did not provide equivalent evidence.\nLumbar spine BMD did not significantly change; a femoral-neck signal arose in a post-hoc subgroup.\nModel: Same 12-month calcium/D3-background trial.\nLimitations: Post-hoc subgroup findings are exploratory; not independent replication.\nEvidence access: Primary abstract\nCholine-stabilized orthosilicic acid supplementation as an adjunct to calcium/vitamin D3 stimulates markers of bone formation in osteopenic females: a randomized, placebo-controlled trial. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18547426/ · DOI 10.1186/1471-2474-9-85","model_system":"Same 12-month calcium/D3-background trial.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc4b461e-dd46-57ab-8213-8aeb7ff9e8d0","stable_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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