{"id":"3502d3b4-3677-5503-a31e-3fe4400b26c1","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-formulation-absorption","predicate":"has_formulation_specific_recovery","statement":"Urinary recovery was approximately 43% for orthosilicic acid, 17% for choline-stabilized acid and 1% for colloidal silica in this comparison.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"3401b99a-f60d-5084-890e-bddf50f1585e","mechanism_event_label":"The same elemental amount need not deliver the same soluble exposure.","subject":{"id":"ffc6fc7f-212c-5bfc-a6f1-bd82c4c2b86d","slug":"choline-stabilized-orthosilicic-acid","display_name":"Choline-stabilized orthosilicic acid","entity_type_key":"chemical_species"},"object":{"id":"2fe8cf1b-a29b-535a-9e9c-c1f1259d89d0","slug":"human-silicon-urinary-recovery","display_name":"Urinary silicon recovery after oral preparations","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"3401b99a-f60d-5084-890e-bddf50f1585e","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-formulation-absorption-event","event_type":"observed_relationship","label":"The same elemental amount need not deliver the same soluble exposure.","description":"Urinary recovery was approximately 43% for orthosilicic acid, 17% for choline-stabilized acid and 1% for colloidal silica in this comparison.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"ffc6fc7f-212c-5bfc-a6f1-bd82c4c2b86d","slug":"choline-stabilized-orthosilicic-acid","display_name":"Choline-stabilized orthosilicic acid","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"2fe8cf1b-a29b-535a-9e9c-c1f1259d89d0","slug":"human-silicon-urinary-recovery","display_name":"Urinary silicon recovery after oral preparations","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"c497144d-1e90-5176-a475-2d715992f5b0","slug":"orthosilicic-acid","display_name":"Orthosilicic acid / Si(OH)4","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"5eb47f46-5727-5236-8e42-c2c85ed5c66a","slug":"amorphous-silica-particles","display_name":"Amorphous silica particles","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"8e1d19fd-ad66-575d-81c4-9122f78915e5","slug":"choline","display_name":"Choline","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Small crossover comparisons; colloidal silica n=3, other sources at least five.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Different preparations and dissolution; not proof that choline itself suppresses absorption or defines a cofactor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"The same elemental amount need not deliver the same soluble exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The comparative absorption of silicon from different foods and food supplements. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19356271/ · DOI 10.1017/S0007114509311757","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"d367f95f-35aa-59f9-968f-cec079c17975","evidence_kind":"source_excerpt","locator":"Lines 80-86","start_line":80,"end_line":86,"excerpt":"## silica-formulation-absorption\nThe same elemental amount need not deliver the same soluble exposure.\nUrinary recovery was approximately 43% for orthosilicic acid, 17% for choline-stabilized acid and 1% for colloidal silica in this comparison.\nModel: Small crossover comparisons; colloidal silica n=3, other sources at least five.\nLimitations: Different preparations and dissolution; not proof that choline itself suppresses absorption or defines a cofactor.\nEvidence access: Primary abstract\nThe comparative absorption of silicon from different foods and food supplements. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19356271/ · DOI 10.1017/S0007114509311757","model_system":"Small crossover comparisons; colloidal silica n=3, other sources at least five.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc4b461e-dd46-57ab-8213-8aeb7ff9e8d0","stable_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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