{"id":"ba645c32-b694-5405-a925-24e61f7fc9ff","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-renal-clearance","predicate":"undergoes","statement":"Reported silicon renal clearance was 82–96 mL/min and correlated with creatinine clearance.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"900255fc-4210-5b7e-81bd-bd7779fd0bb1","mechanism_event_label":"Kidney function affects measured silicon handling.","subject":{"id":"c497144d-1e90-5176-a475-2d715992f5b0","slug":"orthosilicic-acid","display_name":"Orthosilicic acid / Si(OH)4","entity_type_key":"small_molecule"},"object":{"id":"6a8495d6-c1ee-52cc-8cdb-cebe774cdb0b","slug":"human-silicon-renal-clearance","display_name":"Renal clearance of silicon in humans","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"900255fc-4210-5b7e-81bd-bd7779fd0bb1","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-renal-clearance-event","event_type":"observed_relationship","label":"Kidney function affects measured silicon handling.","description":"Reported silicon renal clearance was 82–96 mL/min and correlated with creatinine clearance.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c497144d-1e90-5176-a475-2d715992f5b0","slug":"orthosilicic-acid","display_name":"Orthosilicic acid / Si(OH)4","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"6a8495d6-c1ee-52cc-8cdb-cebe774cdb0b","slug":"human-silicon-renal-clearance","display_name":"Renal clearance of silicon in humans","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Healthy volunteer kinetics.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No universal tissue sufficiency threshold follows from serum or urine silicon.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Kidney function affects measured silicon handling.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10612067/ · DOI 10.1016/s0162-0134(99)00126-9","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f324efb4-774a-52ba-a518-f02cd7a365b2","evidence_kind":"source_excerpt","locator":"Lines 72-78","start_line":72,"end_line":78,"excerpt":"## silica-renal-clearance\nKidney function affects measured silicon handling.\nReported silicon renal clearance was 82–96 mL/min and correlated with creatinine clearance.\nModel: Healthy volunteer kinetics.\nLimitations: No universal tissue sufficiency threshold follows from serum or urine silicon.\nEvidence access: Primary abstract\nSilicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10612067/ · DOI 10.1016/s0162-0134(99)00126-9","model_system":"Healthy volunteer kinetics.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc4b461e-dd46-57ab-8213-8aeb7ff9e8d0","stable_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"e05d81962a1ca6cbfc68fce4fd3dbcdea67c8e61332c19f4fec5d0c3ab8bf1b9","revision_id":"6433ed49-a331-571b-a611-21e56c3ce4bc","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}