{"id":"44d54e1b-388c-5eb5-b32e-8ac5d5f2526c","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-oral-uptake","predicate":"undergoes","statement":"Median minimum uptake estimated from urine was 50.3% in eight volunteers receiving orthosilicic acid.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f50296f5-ad62-5d55-928f-7e74313cef27","mechanism_event_label":"A substantial fraction of soluble silicon entered the body.","subject":{"id":"c497144d-1e90-5176-a475-2d715992f5b0","slug":"orthosilicic-acid","display_name":"Orthosilicic acid / Si(OH)4","entity_type_key":"small_molecule"},"object":{"id":"10fb6119-c4a8-5cf2-89b1-2049f6cf30d6","slug":"human-soluble-silicon-absorption","display_name":"Human gastrointestinal uptake of soluble silicon","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f50296f5-ad62-5d55-928f-7e74313cef27","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-oral-uptake-event","event_type":"observed_relationship","label":"A substantial fraction of soluble silicon entered the body.","description":"Median minimum uptake estimated from urine was 50.3% in eight volunteers receiving orthosilicic acid.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c497144d-1e90-5176-a475-2d715992f5b0","slug":"orthosilicic-acid","display_name":"Orthosilicic acid / Si(OH)4","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"10fb6119-c4a8-5cf2-89b1-2049f6cf30d6","slug":"human-soluble-silicon-absorption","display_name":"Human gastrointestinal uptake of soluble silicon","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Water containing 27–55 mg Si/L; small human kinetic study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Urinary recovery is a lower-bound estimate, not direct intracellular measurement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A substantial fraction of soluble silicon entered the body.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10612067/ · DOI 10.1016/s0162-0134(99)00126-9","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"55744af2-17f3-554a-94fb-6c1ea51c8374","evidence_kind":"source_excerpt","locator":"Lines 64-70","start_line":64,"end_line":70,"excerpt":"## silica-oral-uptake\nA substantial fraction of soluble silicon entered the body.\nMedian minimum uptake estimated from urine was 50.3% in eight volunteers receiving orthosilicic acid.\nModel: Water containing 27–55 mg Si/L; small human kinetic study.\nLimitations: Urinary recovery is a lower-bound estimate, not direct intracellular measurement.\nEvidence access: Primary abstract\nSilicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10612067/ · DOI 10.1016/s0162-0134(99)00126-9","model_system":"Water containing 27–55 mg Si/L; small human kinetic study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc4b461e-dd46-57ab-8213-8aeb7ff9e8d0","stable_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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