{"id":"b20a4a27-1058-5fe8-b0d5-59e2a6364beb","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-dimethyl-form","predicate":"has_distinct_effect","statement":"Dimethylsilanediol had no discernible survival effect up to 50 micromolar and increased survival at higher tested doses.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4599fdec-888b-5d1d-b671-88f1d82d08f2","mechanism_event_label":"An organosilicon compound produced a different cellular response.","subject":{"id":"14bb41ec-ffbd-5da0-827f-4ad96a58eac7","slug":"dimethylsilanediol","display_name":"Dimethylsilanediol","entity_type_key":"small_molecule"},"object":{"id":"e1d23354-d41c-518b-84e8-4c48c378c918","slug":"human-saos2-survival","display_name":"Human Saos-2 colony survival","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4599fdec-888b-5d1d-b671-88f1d82d08f2","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-dimethyl-form-event","event_type":"observed_relationship","label":"An organosilicon compound produced a different cellular response.","description":"Dimethylsilanediol had no discernible survival effect up to 50 micromolar and increased survival at higher tested doses.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"14bb41ec-ffbd-5da0-827f-4ad96a58eac7","slug":"dimethylsilanediol","display_name":"Dimethylsilanediol","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"e1d23354-d41c-518b-84e8-4c48c378c918","slug":"human-saos2-survival","display_name":"Human Saos-2 colony survival","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"c497144d-1e90-5176-a475-2d715992f5b0","slug":"orthosilicic-acid","display_name":"Orthosilicic acid / Si(OH)4","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human osteoblast-like cell comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Environmental silicone degradation product, not evidence that silicone polymers or supplements share this activity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"An organosilicon compound produced a different cellular response.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Divergent effects of orthosilicic acid and dimethylsilanediol on cell survival and adhesion in human osteoblast-like cells. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18755397/ · DOI 10.1016/j.jtemb.2008.02.001","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"698e43b7-acab-57db-a3d7-d3d54fbde2fc","evidence_kind":"source_excerpt","locator":"Lines 208-214","start_line":208,"end_line":214,"excerpt":"## silica-dimethyl-form\nAn organosilicon compound produced a different cellular response.\nDimethylsilanediol had no discernible survival effect up to 50 micromolar and increased survival at higher tested doses.\nModel: Human osteoblast-like cell comparison.\nLimitations: Environmental silicone degradation product, not evidence that silicone polymers or supplements share this activity.\nEvidence access: Primary abstract\nDivergent effects of orthosilicic acid and dimethylsilanediol on cell survival and adhesion in human osteoblast-like cells. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18755397/ · DOI 10.1016/j.jtemb.2008.02.001","model_system":"Human osteoblast-like cell comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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