Component

Aluminum(III)

Context-specific entity; species, compartment and exposure are stated on each claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. The monomeric preparation did not significantly reduce aluminum availability in the same study.

    Orthosilicic acid / Si(OH)4 → Aluminum(III) source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Same three-person human tracer experiment.
    limitations
    Chemical-form difference is not a scientific contradiction.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    Soluble monomers and oligomers do not behave identically.
    primary_references
    Oligomeric but not monomeric silica prevents aluminum absorption in humans. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10731501/ · DOI 10.1093/ajcn/71.4.944

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 96–102

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Same three-person human tracer experiment. · source_derived_draft · unverified_draft

    ## silica-monomer-aluminum-null Soluble monomers and oligomers do not behave identically. The monomeric preparation did not significantly reduce aluminum availability in the same study. Model: Same three-person human tracer experiment. Limitations: Chemical-form difference is not a scientific contradiction. Evidence access: Primary abstract Oligomeric but not monomeric silica prevents aluminum absorption in humans. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10731501/ · DOI 10.1093/ajcn/71.4.944
    Complete structured claim and evidence

  2. Oligomeric silica reduced aluminum tracer availability by 67% in the three-person comparison.

    Oligomeric silicic acid → Aluminum(III) source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human aluminum-26 tracer study; 17 mg silica preparation as reported.
    limitations
    Very small study; does not establish treatment of aluminum toxicity.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A less readily absorbed polymer can bind aluminum in the gut.
    primary_references
    Oligomeric but not monomeric silica prevents aluminum absorption in humans. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10731501/ · DOI 10.1093/ajcn/71.4.944

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 88–94

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human aluminum-26 tracer study; 17 mg silica preparation as reported. · source_derived_draft · unverified_draft

    ## silica-oligomer-aluminum A less readily absorbed polymer can bind aluminum in the gut. Oligomeric silica reduced aluminum tracer availability by 67% in the three-person comparison. Model: Human aluminum-26 tracer study; 17 mg silica preparation as reported. Limitations: Very small study; does not establish treatment of aluminum toxicity. Evidence access: Primary abstract Oligomeric but not monomeric silica prevents aluminum absorption in humans. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10731501/ · DOI 10.1093/ajcn/71.4.944
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Orthosilicic acid in water did not significantly increase endogenous aluminum excretion over 32 hours in five volunteers.

    Orthosilicic acid / Si(OH)4 → Human urinary aluminum excretion source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Water dosing, small human kinetic study.
    limitations
    Different matrix, baseline aluminum and timing may matter; urinary output is not a measurement of brain aluminum.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A separate human study did not reproduce increased aluminum clearance.
    primary_references
    Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10612067/ · DOI 10.1016/s0162-0134(99)00126-9

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 112–118

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Water dosing, small human kinetic study. · source_derived_draft · unverified_draft

    ## silica-aluminum-urine-null A separate human study did not reproduce increased aluminum clearance. Orthosilicic acid in water did not significantly increase endogenous aluminum excretion over 32 hours in five volunteers. Model: Water dosing, small human kinetic study. Limitations: Different matrix, baseline aluminum and timing may matter; urinary output is not a measurement of brain aluminum. Evidence access: Primary abstract Silicic acid: its gastrointestinal uptake and urinary excretion in man and effects on aluminium excretion. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10612067/ · DOI 10.1016/s0162-0134(99)00126-9
    Complete structured claim and evidence

  2. Beer-derived monosilicic acid ingestion was accompanied by increased urinary aluminum in this study.

    Orthosilicic acid / Si(OH)4 → Human urinary aluminum excretion source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Healthy volunteers; beverage matrix and isotope experiments.
    limitations
    Kidney-lumen complex formation and reduced reabsorption were proposed, not directly established molecular targets.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A renal effect was proposed in addition to intestinal binding.
    primary_references
    The role of silicic acid in the renal excretion of aluminium. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8726215/

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 104–110

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Healthy volunteers; beverage matrix and isotope experiments. · source_derived_draft · unverified_draft

    ## silica-aluminum-urine-positive A renal effect was proposed in addition to intestinal binding. Beer-derived monosilicic acid ingestion was accompanied by increased urinary aluminum in this study. Model: Healthy volunteers; beverage matrix and isotope experiments. Limitations: Kidney-lumen complex formation and reduced reabsorption were proposed, not directly established molecular targets. Evidence access: Primary abstract The role of silicic acid in the renal excretion of aluminium. · 1996 · https://pubmed.ncbi.nlm.nih.gov/8726215/
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards