{"id":"28cd5037-268c-5322-988c-e248af1afe76","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-oligomer-aluminum","predicate":"reduces_intestinal_availability","statement":"Oligomeric silica reduced aluminum tracer availability by 67% in the three-person comparison.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"d07717ec-17af-581e-9e0a-73aca33b96ce","mechanism_event_label":"A less readily absorbed polymer can bind aluminum in the gut.","subject":{"id":"d528d7fc-4f06-54a5-b6cf-a6ccbd55b452","slug":"oligomeric-silicic-acid","display_name":"Oligomeric silicic acid","entity_type_key":"chemical_species"},"object":{"id":"88d3484c-e93c-56ea-bc7d-545559b4c82e","slug":"aluminum-iii","display_name":"Aluminum(III)","entity_type_key":"ion"},"evidence_count":1,"mechanism_event":{"id":"d07717ec-17af-581e-9e0a-73aca33b96ce","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-oligomer-aluminum-event","event_type":"observed_relationship","label":"A less readily absorbed polymer can bind aluminum in the gut.","description":"Oligomeric silica reduced aluminum tracer availability by 67% in the three-person comparison.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"d528d7fc-4f06-54a5-b6cf-a6ccbd55b452","slug":"oligomeric-silicic-acid","display_name":"Oligomeric silicic acid","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"88d3484c-e93c-56ea-bc7d-545559b4c82e","slug":"aluminum-iii","display_name":"Aluminum(III)","entity_type_key":"ion"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human aluminum-26 tracer study; 17 mg silica preparation as reported.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Very small study; does not establish treatment of aluminum toxicity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A less readily absorbed polymer can bind aluminum in the gut.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Oligomeric but not monomeric silica prevents aluminum absorption in humans. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10731501/ · DOI 10.1093/ajcn/71.4.944","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"362497bd-1181-59d8-b81d-48bb3f09b53d","evidence_kind":"source_excerpt","locator":"Lines 88-94","start_line":88,"end_line":94,"excerpt":"## silica-oligomer-aluminum\nA less readily absorbed polymer can bind aluminum in the gut.\nOligomeric silica reduced aluminum tracer availability by 67% in the three-person comparison.\nModel: Human aluminum-26 tracer study; 17 mg silica preparation as reported.\nLimitations: Very small study; does not establish treatment of aluminum toxicity.\nEvidence access: Primary abstract\nOligomeric but not monomeric silica prevents aluminum absorption in humans. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10731501/ · DOI 10.1093/ajcn/71.4.944","model_system":"Human aluminum-26 tracer study; 17 mg silica preparation as reported.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc4b461e-dd46-57ab-8213-8aeb7ff9e8d0","stable_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"e05d81962a1ca6cbfc68fce4fd3dbcdea67c8e61332c19f4fec5d0c3ab8bf1b9","revision_id":"6433ed49-a331-571b-a611-21e56c3ce4bc","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}