{"id":"40f5bbe6-6f5b-5a0d-a1a1-e56b9984ff7f","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-pi3k-mtor","predicate":"increases_pathway_markers","statement":"Orthosilicic acid increased PI3K, phosphorylated Akt and mTOR together with osteogenic markers.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b9fc68cb-7a70-5313-ba38-36d929b74480","mechanism_event_label":"A growth-related pathway accompanied matrix production.","subject":{"id":"c497144d-1e90-5176-a475-2d715992f5b0","slug":"orthosilicic-acid","display_name":"Orthosilicic acid / Si(OH)4","entity_type_key":"small_molecule"},"object":{"id":"779b2149-a16f-58b8-815b-7f1f2620da1f","slug":"mtor","display_name":"Human mechanistic target of rapamycin kinase / MTOR","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"b9fc68cb-7a70-5313-ba38-36d929b74480","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-pi3k-mtor-event","event_type":"observed_relationship","label":"A growth-related pathway accompanied matrix production.","description":"Orthosilicic acid increased PI3K, phosphorylated Akt and mTOR together with osteogenic markers.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c497144d-1e90-5176-a475-2d715992f5b0","slug":"orthosilicic-acid","display_name":"Orthosilicic acid / Si(OH)4","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"779b2149-a16f-58b8-815b-7f1f2620da1f","slug":"mtor","display_name":"Human mechanistic target of rapamycin kinase / MTOR","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a13cb592-c939-5f92-9206-d774248802fc","slug":"akt-proteins","display_name":"AKT serine/threonine kinase family","entity_type_key":"protein_family"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"30dd8e5f-7abe-5fd5-927d-e8204e5de6e5","slug":"runx2","display_name":"RUNX2","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"091a1ec0-5867-5659-b199-b73a1ac8b9c6","slug":"human-type-i-collagen","display_name":"Human type I collagen","entity_type_key":"protein_complex"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human osteoblast-like cell study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"No direct binding target or dietary requirement is established.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A growth-related pathway accompanied matrix production.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Orthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30421162/ · DOI 10.1007/s12011-018-1574-9","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"18a1f5f1-7905-5925-ac4d-af2c62db54ba","evidence_kind":"source_excerpt","locator":"Lines 168-174","start_line":168,"end_line":174,"excerpt":"## silica-pi3k-mtor\nA growth-related pathway accompanied matrix production.\nOrthosilicic acid increased PI3K, phosphorylated Akt and mTOR together with osteogenic markers.\nModel: Human osteoblast-like cell study.\nLimitations: No direct binding target or dietary requirement is established.\nEvidence access: Primary abstract\nOrthosilicic Acid Accelerates Bone Formation in Human Osteoblast-Like Cells Through the PI3K-Akt-mTOR Pathway. · 2019 · https://pubmed.ncbi.nlm.nih.gov/30421162/ · DOI 10.1007/s12011-018-1574-9","model_system":"Human osteoblast-like cell study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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