{"id":"61241e90-11f7-5713-9bad-16f576c39c4f","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-aqp9-phloretin","predicate":"increases_silicon_influx_via","statement":"Phloretin increased AQP9-mediated silicon influx under the tested hypoosmolar conditions while inhibiting water transport.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8b854e5b-96d2-54ca-8d08-c25cd1d714f2","mechanism_event_label":"A transport inhibitor can affect two substrates differently.","subject":{"id":"83949207-904f-53dc-bc9d-f7afaa546b34","slug":"phloretin","display_name":"Phloretin","entity_type_key":"small_molecule"},"object":{"id":"9220a6e9-b494-54d7-8376-e75269ab9e07","slug":"aqp9","display_name":"Human aquaporin 9 / AQP9","entity_type_key":"protein"},"evidence_count":1,"mechanism_event":{"id":"8b854e5b-96d2-54ca-8d08-c25cd1d714f2","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-aqp9-phloretin-event","event_type":"observed_relationship","label":"A transport inhibitor can affect two substrates differently.","description":"Phloretin increased AQP9-mediated silicon influx under the tested hypoosmolar conditions while inhibiting water transport.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"83949207-904f-53dc-bc9d-f7afaa546b34","slug":"phloretin","display_name":"Phloretin","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"9220a6e9-b494-54d7-8376-e75269ab9e07","slug":"aqp9","display_name":"Human aquaporin 9 / AQP9","entity_type_key":"protein"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"c497144d-1e90-5176-a475-2d715992f5b0","slug":"orthosilicic-acid","display_name":"Orthosilicic acid / Si(OH)4","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human AQP9 in Xenopus oocytes; 0.1 mM phloretin, 2 mM silicic acid.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a demonstrated food interaction; the abstract’s phloretin-sensitive wording does not mean silicon flux was inhibited.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A transport inhibitor can affect two substrates differently.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"f4d5ae81-c1f1-54ec-9d26-d9b299ed9e82","evidence_kind":"source_excerpt","locator":"Lines 56-62","start_line":56,"end_line":62,"excerpt":"## silica-aqp9-phloretin\nA transport inhibitor can affect two substrates differently.\nPhloretin increased AQP9-mediated silicon influx under the tested hypoosmolar conditions while inhibiting water transport.\nModel: Human AQP9 in Xenopus oocytes; 0.1 mM phloretin, 2 mM silicic acid.\nLimitations: Not a demonstrated food interaction; the abstract’s phloretin-sensitive wording does not mean silicon flux was inhibited.\nEvidence access: Primary full text\nAquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149","model_system":"Human AQP9 in Xenopus oocytes; 0.1 mM phloretin, 2 mM silicic acid.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc4b461e-dd46-57ab-8213-8aeb7ff9e8d0","stable_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"e05d81962a1ca6cbfc68fce4fd3dbcdea67c8e61332c19f4fec5d0c3ab8bf1b9","revision_id":"6433ed49-a331-571b-a611-21e56c3ce4bc","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}