{"id":"b814f360-1f74-51f9-8110-5a88dad4edf6","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-mouse-antimir","predicate":"suppresses","statement":"Anti-miR-146a suppressed differentiation in MC3T3 preosteoblasts in the silicate study.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ab449d25-7136-511b-a181-a11797dd1656","mechanism_event_label":"Removing a regulatory RNA weakened bone-cell maturation.","subject":{"id":"4f344a70-e447-570d-b8d1-4401146725d3","slug":"mouse-mir146a-antagonism","display_name":"Anti-miR-146a treatment in mouse MC3T3 cells","entity_type_key":"cellular_process"},"object":{"id":"8acf582c-1b41-52f4-af19-e5d5be1999e4","slug":"mouse-osteoblast-differentiation","display_name":"Mouse osteoblast differentiation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ab449d25-7136-511b-a181-a11797dd1656","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-mouse-antimir-event","event_type":"observed_relationship","label":"Removing a regulatory RNA weakened bone-cell maturation.","description":"Anti-miR-146a suppressed differentiation in MC3T3 preosteoblasts in the silicate study.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4f344a70-e447-570d-b8d1-4401146725d3","slug":"mouse-mir146a-antagonism","display_name":"Anti-miR-146a treatment in mouse MC3T3 cells","entity_type_key":"cellular_process"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"8acf582c-1b41-52f4-af19-e5d5be1999e4","slug":"mouse-osteoblast-differentiation","display_name":"Mouse osteoblast differentiation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"c497144d-1e90-5176-a475-2d715992f5b0","slug":"orthosilicic-acid","display_name":"Orthosilicic acid / Si(OH)4","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"64d56dad-2622-588a-8f38-9ce3b206cdc2","slug":"mouse-mir146a","display_name":"Mouse miR-146a","entity_type_key":"rna"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; 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