{"id":"ffad5f8f-0182-513e-989a-329c216d6b8b","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-aqp3-transport","predicate":"transports","statement":"Expression of human AQP3 increased silicon transport in the tested oocyte and HEK-293 systems.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c74ce159-a757-5c42-959a-fd4f9d58e7aa","mechanism_event_label":"AQP3 provides a separately identifiable route for soluble silicon.","subject":{"id":"e336f1e3-061e-5192-b473-a40b93c55b3e","slug":"aqp3","display_name":"Human aquaporin 3 / AQP3","entity_type_key":"protein"},"object":{"id":"c497144d-1e90-5176-a475-2d715992f5b0","slug":"orthosilicic-acid","display_name":"Orthosilicic acid / Si(OH)4","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"c74ce159-a757-5c42-959a-fd4f9d58e7aa","stable_key":"3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd:silica-aqp3-transport-event","event_type":"observed_relationship","label":"AQP3 provides a separately identifiable route for soluble silicon.","description":"Expression of human AQP3 increased silicon transport in the tested oocyte and HEK-293 systems.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"e336f1e3-061e-5192-b473-a40b93c55b3e","slug":"aqp3","display_name":"Human aquaporin 3 / AQP3","entity_type_key":"protein"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c497144d-1e90-5176-a475-2d715992f5b0","slug":"orthosilicic-acid","display_name":"Orthosilicic acid / Si(OH)4","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"11b1cdb5-1b10-586b-9917-b4da18ac072f","slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary full text","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human constructs in Xenopus oocytes and human HEK-293 cells.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Expression-system flux does not establish the dominant transporter in every human tissue.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"silica","display_name":"Silica and soluble silicon","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"AQP3 provides a separately identifiable route for soluble silicon.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"transport_effect","value_text":"raises","comparator":null,"unit":null,"notes":"Expression increased silicon transport in the oocyte and HEK-293 uptake systems.","entity":null},{"dimension":"transport_pool","value_text":"the expressing cell","comparator":null,"unit":null,"notes":"Expression increased silicon transport in the oocyte and HEK-293 uptake systems.","entity":null}],"evidence":[{"id":"d33a1fbf-ef19-5d4f-a3d0-70621385c886","evidence_kind":"source_excerpt","locator":"Lines 16-22","start_line":16,"end_line":22,"excerpt":"## silica-aqp3-transport\nAQP3 provides a separately identifiable route for soluble silicon.\nExpression of human AQP3 increased silicon transport in the tested oocyte and HEK-293 systems.\nModel: Human constructs in Xenopus oocytes and human HEK-293 cells.\nLimitations: Expression-system flux does not establish the dominant transporter in every human tissue.\nEvidence access: Primary full text\nAquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149","model_system":"Human constructs in Xenopus oocytes and human HEK-293 cells.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"dc4b461e-dd46-57ab-8213-8aeb7ff9e8d0","stable_key":"import-3b71c9a2-e2fe-5ab8-a85b-15ae1be836dd","title":"Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary references, access levels and experimental limitations individually identified. 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