Component

Human aquaporin 9 / AQP9

Context-specific entity; species, compartment and exposure are stated on each claim.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Expression of human AQP9 increased silicon transport in the tested oocyte and HEK-293 systems.

    Human aquaporin 9 / AQP9 → Orthosilicic acid / Si(OH)4 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Human constructs in Xenopus oocytes and human HEK-293 cells.
    limitations
    Expression-system flux does not establish the dominant transporter in every human tissue.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    AQP9 provides a separately identifiable route for soluble silicon.
    primary_references
    Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149
    transport_effect
    raises Expression increased silicon transport in the oocyte and HEK-293 uptake systems.
    transport_pool
    the expressing cell Expression increased silicon transport in the oocyte and HEK-293 uptake systems.

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 32–38

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human constructs in Xenopus oocytes and human HEK-293 cells. · source_derived_draft · unverified_draft

    ## silica-aqp9-transport AQP9 provides a separately identifiable route for soluble silicon. Expression of human AQP9 increased silicon transport in the tested oocyte and HEK-293 systems. Model: Human constructs in Xenopus oocytes and human HEK-293 cells. Limitations: Expression-system flux does not establish the dominant transporter in every human tissue. Evidence access: Primary full text Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149
    Complete structured claim and evidence

What acts on it

  1. Phloretin increased AQP9-mediated silicon influx under the tested hypoosmolar conditions while inhibiting water transport.

    Phloretin → Human aquaporin 9 / AQP9 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Human AQP9 in Xenopus oocytes; 0.1 mM phloretin, 2 mM silicic acid.
    limitations
    Not a demonstrated food interaction; the abstract’s phloretin-sensitive wording does not mean silicon flux was inhibited.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    A transport inhibitor can affect two substrates differently.
    primary_references
    Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 56–62

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human AQP9 in Xenopus oocytes; 0.1 mM phloretin, 2 mM silicic acid. · source_derived_draft · unverified_draft

    ## silica-aqp9-phloretin A transport inhibitor can affect two substrates differently. Phloretin increased AQP9-mediated silicon influx under the tested hypoosmolar conditions while inhibiting water transport. Model: Human AQP9 in Xenopus oocytes; 0.1 mM phloretin, 2 mM silicic acid. Limitations: Not a demonstrated food interaction; the abstract’s phloretin-sensitive wording does not mean silicon flux was inhibited. Evidence access: Primary full text Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149
    Complete structured claim and evidence

  2. AQP9 mRNA increased significantly at 72 hours during silicon exposure.

    Silicon preparation containing 75% orthosilicic acid → Human aquaporin 9 / AQP9 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text
    experimental_model
    Human CD14+ osteoclast cultures.
    limitations
    No AQP9 loss-of-function test demonstrated that it mediated the resorption effect.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    Transporter expression changed even while differentiation markers fell.
    primary_references
    Orthosilicic acid inhibits human osteoclast differentiation and bone resorption. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39405281/ · DOI 10.1371/journal.pone.0312169

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 256–262

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human CD14+ osteoclast cultures. · source_derived_draft · unverified_draft

    ## silica-osteoclast-aqp9 Transporter expression changed even while differentiation markers fell. AQP9 mRNA increased significantly at 72 hours during silicon exposure. Model: Human CD14+ osteoclast cultures. Limitations: No AQP9 loss-of-function test demonstrated that it mediated the resorption effect. Evidence access: Primary full text Orthosilicic acid inhibits human osteoclast differentiation and bone resorption. · 2024 · https://pubmed.ncbi.nlm.nih.gov/39405281/ · DOI 10.1371/journal.pone.0312169
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Combined AQP3/AQP7/AQP9/AQP10 RNA interference reduced silicon efflux from preloaded HEK-293 cells.

    Combined human aquaglyceroporin silencing → Silicon efflux from human HEK-293 cells source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    machinery_impairment Imported condition classification; unverified.
    evidence_access
    Primary full text
    experimental_model
    Human HEK-293 cells, 2 mM loading and brief efflux assay.
    limitations
    Combined knockdown does not quantify each channel’s independent in-vivo contribution.
    nutrient_topic
    Silica collection; molecular form, preparation, species, exposure and manipulation remain explicit. · Silica and soluble silicon
    plain_language
    Loss of transport machinery changes silicon movement.
    primary_references
    Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149
    trigger_kind
    machinery_impairment Imported condition classification; unverified.

    Silica: soluble silicon, cellular transport and particle-specific mechanisms (2026-09-19) · lines 48–54

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human HEK-293 cells, 2 mM loading and brief efflux assay. · source_derived_draft · unverified_draft

    ## silica-aqp-silencing Loss of transport machinery changes silicon movement. Combined AQP3/AQP7/AQP9/AQP10 RNA interference reduced silicon efflux from preloaded HEK-293 cells. Model: Human HEK-293 cells, 2 mM loading and brief efflux assay. Limitations: Combined knockdown does not quantify each channel’s independent in-vivo contribution. Evidence access: Primary full text Aquaporins Mediate Silicon Transport in Humans. · 2015 · https://pubmed.ncbi.nlm.nih.gov/26313002/ · DOI 10.1371/journal.pone.0136149
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards