Component

Brachial artery flow-mediated dilation

Independent biological entity. Read linked claims for experimental scope and context.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Both coffee formulations produced biphasic FMD increases accompanied by circulating CGA metabolites.

    Coffee chlorogenic-acid mixture, composition study-specific → Brachial artery flow-mediated dilation source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/chlorogenic_acid-research/28012692.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "78c6f096f5e1ec58c1a1c2a7aacda48cadf220053e0f7bff5962c93188429d03", "start_char": 0, "end_char": 1766, "text_sha256": "78c6f096f5e1ec58c1a1c2a7aacda48cadf220053e0f7bff5962c93188429d03"}
    experimental_model
    Two acute randomized controlled crossover trials
    exposure
    Coffee with 89 or 310 mg CGAs, matched caffeine, n=15; pure 5-CQA 450/900 mg, n=24
    limitations
    Coffee is a mixture. Parallel metabolite timing is not proof that a specific metabolite caused dilation. The pure-compound P=0.06 result did not meet the conventional P<0.05 threshold.
    nutrient_topic
    Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
    organism
    Human healthy men
    plain_language
    A coffee result includes the beverage matrix.
    primary_references
    [chlorogenic_acid-p28012692] Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials. (2017). https://pubmed.ncbi.nlm.nih.gov/28012692/ DOI: 10.1016/j.clnu.2016.11.013
    tissue_or_cell_type
    Brachial FMD and plasma metabolites

    Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 997–1008

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Two acute randomized controlled crossover trials · source_derived_draft · unverified_draft

    ### chlorogenic_acid-coffee-fmd Both coffee formulations produced biphasic FMD increases accompanied by circulating CGA metabolites. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: A coffee result includes the beverage matrix. organism: Human healthy men tissue_or_cell_type: Brachial FMD and plasma metabolites experimental_model: Two acute randomized controlled crossover trials limitations: Coffee is a mixture. Parallel metabolite timing is not proof that a specific metabolite caused dilation. The pure-compound P=0.06 result did not meet the conventional P<0.05 threshold. exposure: Coffee with 89 or 310 mg CGAs, matched caffeine, n=15; pure 5-CQA 450/900 mg, n=24 evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/28012692.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "78c6f096f5e1ec58c1a1c2a7aacda48cadf220053e0f7bff5962c93188429d03", "start_char": 0, "end_char": 1766, "text_sha256": "78c6f096f5e1ec58c1a1c2a7aacda48cadf220053e0f7bff5962c93188429d03"} [chlorogenic_acid-p28012692] Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials. (2017). https://pubmed.ncbi.nlm.nih.gov/28012692/ DOI: 10.1016/j.clnu.2016.11.013
    Complete structured claim and evidence

  2. Neither 450 nor 900 mg significantly changed peak FMD versus control.

    Chlorogenic acid / 5-O-caffeoylquinic acid → Brachial artery flow-mediated dilation source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/chlorogenic_acid-research/27109860.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e8a19a33418ce3a635bd5d8d0d2189175a8e555131a1059441eac4d03dfc91c8", "start_char": 0, "end_char": 1585, "text_sha256": "e8a19a33418ce3a635bd5d8d0d2189175a8e555131a1059441eac4d03dfc91c8"}
    experimental_model
    Randomized-order acute crossover in 16 adults
    exposure
    0, 450 or 900 mg purified 5-CGA; 200 mg epicatechin comparator; one-week spacing
    limitations
    Peak and continuous-mean FMD are different endpoints. Secondary positive findings must not replace the null peak response; no long-term vascular outcome was tested.
    nutrient_topic
    Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
    organism
    Human
    plain_language
    The main peak response was null.
    primary_references
    [chlorogenic_acid-p27109860] Acute effects of chlorogenic acids on endothelial function and blood pressure in healthy men and women. (2016). https://pubmed.ncbi.nlm.nih.gov/27109860/ DOI: 10.1039/c6fo00248j
    tissue_or_cell_type
    Brachial flow-mediated dilation and blood pressure

    Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 958–969

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized-order acute crossover in 16 adults · source_derived_draft · unverified_draft

    ### chlorogenic_acid-peak-fmd-null Neither 450 nor 900 mg significantly changed peak FMD versus control. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The main peak response was null. organism: Human tissue_or_cell_type: Brachial flow-mediated dilation and blood pressure experimental_model: Randomized-order acute crossover in 16 adults limitations: Peak and continuous-mean FMD are different endpoints. Secondary positive findings must not replace the null peak response; no long-term vascular outcome was tested. exposure: 0, 450 or 900 mg purified 5-CGA; 200 mg epicatechin comparator; one-week spacing evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/27109860.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "e8a19a33418ce3a635bd5d8d0d2189175a8e555131a1059441eac4d03dfc91c8", "start_char": 0, "end_char": 1585, "text_sha256": "e8a19a33418ce3a635bd5d8d0d2189175a8e555131a1059441eac4d03dfc91c8"} [chlorogenic_acid-p27109860] Acute effects of chlorogenic acids on endothelial function and blood pressure in healthy men and women. (2016). https://pubmed.ncbi.nlm.nih.gov/27109860/ DOI: 10.1039/c6fo00248j
    Complete structured claim and evidence

  3. The 450 mg pure 5-CQA comparison at one hour had P=0.06.

    Chlorogenic acid / 5-O-caffeoylquinic acid → Brachial artery flow-mediated dilation source_derived_draftungraded
    Experimental context and source evidence
    evidence_span
    {"source_cache": "artifacts/chlorogenic_acid-research/28012692.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "78c6f096f5e1ec58c1a1c2a7aacda48cadf220053e0f7bff5962c93188429d03", "start_char": 0, "end_char": 1766, "text_sha256": "78c6f096f5e1ec58c1a1c2a7aacda48cadf220053e0f7bff5962c93188429d03"}
    experimental_model
    Two acute randomized controlled crossover trials
    exposure
    Coffee with 89 or 310 mg CGAs, matched caffeine, n=15; pure 5-CQA 450/900 mg, n=24
    limitations
    Coffee is a mixture. Parallel metabolite timing is not proof that a specific metabolite caused dilation. The pure-compound P=0.06 result did not meet the conventional P<0.05 threshold.
    nutrient_topic
    Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
    organism
    Human healthy men
    plain_language
    A suggestive trend is retained without calling it a confirmed improvement.
    primary_references
    [chlorogenic_acid-p28012692] Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials. (2017). https://pubmed.ncbi.nlm.nih.gov/28012692/ DOI: 10.1016/j.clnu.2016.11.013
    tissue_or_cell_type
    Brachial FMD and plasma metabolites

    Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 1010–1021

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Two acute randomized controlled crossover trials · source_derived_draft · unverified_draft

    ### chlorogenic_acid-pure-fmd-borderline The 450 mg pure 5-CQA comparison at one hour had P=0.06. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: A suggestive trend is retained without calling it a confirmed improvement. organism: Human healthy men tissue_or_cell_type: Brachial FMD and plasma metabolites experimental_model: Two acute randomized controlled crossover trials limitations: Coffee is a mixture. Parallel metabolite timing is not proof that a specific metabolite caused dilation. The pure-compound P=0.06 result did not meet the conventional P<0.05 threshold. exposure: Coffee with 89 or 310 mg CGAs, matched caffeine, n=15; pure 5-CQA 450/900 mg, n=24 evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/28012692.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "78c6f096f5e1ec58c1a1c2a7aacda48cadf220053e0f7bff5962c93188429d03", "start_char": 0, "end_char": 1766, "text_sha256": "78c6f096f5e1ec58c1a1c2a7aacda48cadf220053e0f7bff5962c93188429d03"} [chlorogenic_acid-p28012692] Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials. (2017). https://pubmed.ncbi.nlm.nih.gov/28012692/ DOI: 10.1016/j.clnu.2016.11.013
    Complete structured claim and evidence

  4. The endothelial substudy found a 1.16-percentage-point increase in flow-mediated dilation with potassium.

    Potassium → Brachial artery flow-mediated dilation source_derived_draftungraded
    Experimental context and source evidence
    experimental_model
    FMD subgroup, 22-24 usable measurements per comparison.
    limitations
    Same parent trial; no direct demonstration of nitric oxide or a particular channel as mediator.
    nutrient_topic
    Potassium research collection; topical membership is not evidence of a direct dietary effect. · Potassium
    organism
    Homo sapiens
    plain_language
    A vessel-response measurement improved in this subgroup.
    primary_references
    [k-gijsbers2015-fmd] Effects of sodium and potassium supplementation on endothelial function: a fully controlled dietary intervention study (2015). https://pubmed.ncbi.nlm.nih.gov/26343780/ DOI: 10.1017/s0007114515002986
    tissue_or_cell_type
    Brachial artery

    Potassium: cross-nutrient mechanisms and deficiency (2026-09-17) · lines 1557–1566

    AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · FMD subgroup, 22-24 usable measurements per comparison. · source_derived_draft · unverified_draft

    ### k-controlled-feeding-fmd The endothelial substudy found a 1.16-percentage-point increase in flow-mediated dilation with potassium. Condition category: normal nutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect. plain_language: A vessel-response measurement improved in this subgroup. organism: Homo sapiens tissue_or_cell_type: Brachial artery experimental_model: FMD subgroup, 22-24 usable measurements per comparison. limitations: Same parent trial; no direct demonstration of nitric oxide or a particular channel as mediator. [k-gijsbers2015-fmd] Effects of sodium and potassium supplementation on endothelial function: a fully controlled dietary intervention study (2015). https://pubmed.ncbi.nlm.nih.gov/26343780/ DOI: 10.1017/s0007114515002986
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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