{"id":"077a3ec1-b92b-5d10-89a0-54443e465356","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-pure-fmd-borderline","predicate":"showed_nonsignificant_trend_in","statement":"The 450 mg pure 5-CQA comparison at one hour had P=0.06.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9cd5254d-a2fb-5db7-982b-6f2d632c3289","mechanism_event_label":"A suggestive trend is retained without calling it a confirmed improvement.","subject":{"id":"705c7f84-5840-55e1-be69-383cc8793a06","slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"},"object":{"id":"a557fb69-ee27-5be9-8318-227c570267ff","slug":"flow-mediated-dilation","display_name":"Brachial artery flow-mediated dilation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9cd5254d-a2fb-5db7-982b-6f2d632c3289","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-pure-fmd-borderline-event","event_type":"observed_intervention","label":"A suggestive trend is retained without calling it a confirmed improvement.","description":"The 450 mg pure 5-CQA comparison at one hour had P=0.06.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"705c7f84-5840-55e1-be69-383cc8793a06","slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a557fb69-ee27-5be9-8318-227c570267ff","slug":"flow-mediated-dilation","display_name":"Brachial artery flow-mediated dilation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chlorogenic_acid-research/28012692.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"78c6f096f5e1ec58c1a1c2a7aacda48cadf220053e0f7bff5962c93188429d03\", \"start_char\": 0, \"end_char\": 1766, \"text_sha256\": \"78c6f096f5e1ec58c1a1c2a7aacda48cadf220053e0f7bff5962c93188429d03\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Two acute randomized controlled crossover trials","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Coffee with 89 or 310 mg CGAs, matched caffeine, n=15; pure 5-CQA 450/900 mg, n=24","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Coffee is a mixture. Parallel metabolite timing is not proof that a specific metabolite caused dilation. The pure-compound P=0.06 result did not meet the conventional P<0.05 threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human healthy men","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A suggestive trend is retained without calling it a confirmed improvement.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chlorogenic_acid-p28012692] Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials. (2017). https://pubmed.ncbi.nlm.nih.gov/28012692/ DOI: 10.1016/j.clnu.2016.11.013","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brachial FMD and plasma metabolites","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2d352a4b-32fd-56d9-b571-eca9bbabc158","evidence_kind":"source_excerpt","locator":"Lines 1010-1021","start_line":1010,"end_line":1021,"excerpt":"### chlorogenic_acid-pure-fmd-borderline\nThe 450 mg pure 5-CQA comparison at one hour had P=0.06.\nCondition category: normal\nnutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A suggestive trend is retained without calling it a confirmed improvement.\norganism: Human healthy men\ntissue_or_cell_type: Brachial FMD and plasma metabolites\nexperimental_model: Two acute randomized controlled crossover trials\nlimitations: Coffee is a mixture. Parallel metabolite timing is not proof that a specific metabolite caused dilation. The pure-compound P=0.06 result did not meet the conventional P<0.05 threshold.\nexposure: Coffee with 89 or 310 mg CGAs, matched caffeine, n=15; pure 5-CQA 450/900 mg, n=24\nevidence_span: {\"source_cache\": \"artifacts/chlorogenic_acid-research/28012692.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"78c6f096f5e1ec58c1a1c2a7aacda48cadf220053e0f7bff5962c93188429d03\", \"start_char\": 0, \"end_char\": 1766, \"text_sha256\": \"78c6f096f5e1ec58c1a1c2a7aacda48cadf220053e0f7bff5962c93188429d03\"}\n[chlorogenic_acid-p28012692] Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials. (2017). https://pubmed.ncbi.nlm.nih.gov/28012692/ DOI: 10.1016/j.clnu.2016.11.013","model_system":"Two acute randomized controlled crossover trials","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [chlorogenic_acid-p28012692] Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials. 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