{"id":"7348710f-59e9-52a2-9121-21aa6ba45bbb","stable_key":"35ec55a7-323c-5c28-979e-3bdafe9d5769:halfcup-fmd-null","predicate":"no_detected_change_in_recorded_experiment","statement":"Half-cup-equivalent blueberry intake did not improve FMD in the six-month trial.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"ae98dd50-88d6-5f33-bd33-5daab333fb45","mechanism_event_label":"Half-cup-equivalent blueberry intake did not improve FMD in the six-month trial.","subject":{"id":"0d35d646-b792-5bce-84d0-0d09fb0aa0aa","slug":"blueberry-powder-curtis-2019","display_name":"Blueberry powder standardized to half- or one-cup equivalents in Curtis 2019","entity_type_key":"botanical"},"object":{"id":"a557fb69-ee27-5be9-8318-227c570267ff","slug":"flow-mediated-dilation","display_name":"Brachial artery flow-mediated dilation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ae98dd50-88d6-5f33-bd33-5daab333fb45","stable_key":"35ec55a7-323c-5c28-979e-3bdafe9d5769:halfcup-fmd-null-event","event_type":"experimental_observation","label":"Half-cup-equivalent blueberry intake did not improve FMD in the six-month trial.","description":"**Clinical nulls remain part of the mechanism reference.** In 115 adults with metabolic syndrome completing a six-month randomized blueberry trial, one-cup-equivalent intake improved FMD, but insulin resistance, blood pressure, pulse-wave velocity, NO and overall plasma thiol status did not significantly improve. Half-cup-equivalent intake did not improve the reported biomarkers. These results do not contradict every short-term purified-compound study; they constrain extrapolation across preparations, durations and endpoints. [Curtis et al., 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6537945/). Its corrigendum changes the insulin unit in Table 2 to mU/L; it does not announce a reversal of the trial's outcomes. [Publisher correction](https://pmc.ncbi.nlm.nih.gov/articles/PMC6821540/).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0d35d646-b792-5bce-84d0-0d09fb0aa0aa","slug":"blueberry-powder-curtis-2019","display_name":"Blueberry powder standardized to half- or one-cup equivalents in Curtis 2019","entity_type_key":"botanical"},"role":"tested factor","stoichiometry":null,"state_label":"Half-cup-equivalent blueberry powder daily","sequence_order":0,"notes":""},{"entity":{"id":"a557fb69-ee27-5be9-8318-227c570267ff","slug":"flow-mediated-dilation","display_name":"Brachial artery flow-mediated dilation","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"no_detected_change","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Full text retrieved; relevant methods/results/figure text reviewed. No independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"Half-cup-equivalent blueberry powder daily\", \"comparator\": \"Matched placebo\", \"endpoint\": \"Half-cup-equivalent blueberry intake did not improve FMD in the six-month trial.\", \"effect_direction\": \"no_detected_change\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"Metabolic syndrome; half-cup-equivalent arm; six months.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not establish a universal daily-dose threshold.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Half-cup-equivalent blueberry intake did not improve FMD in the six-month trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial. | 2019 | DOI 10.1093/ajcn/nqy380 | PMID 31136659 | https://pubmed.ncbi.nlm.nih.gov/31136659/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6537945/ | https://doi.org/10.1093/ajcn/nqy380","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 62-62; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"e987b430-05c9-575c-8388-ab35a7a43811","evidence_kind":"source_excerpt","locator":"Lines 62-62","start_line":62,"end_line":62,"excerpt":"**Clinical nulls remain part of the mechanism reference.** In 115 adults with metabolic syndrome completing a six-month randomized blueberry trial, one-cup-equivalent intake improved FMD, but insulin resistance, blood pressure, pulse-wave velocity, NO and overall plasma thiol status did not significantly improve. Half-cup-equivalent intake did not improve the reported biomarkers. These results do not contradict every short-term purified-compound study; they constrain extrapolation across preparations, durations and endpoints. [Curtis et al., 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6537945/). Its corrigendum changes the insulin unit in Table 2 to mU/L; it does not announce a reversal of the trial's outcomes. [Publisher correction](https://pmc.ncbi.nlm.nih.gov/articles/PMC6821540/).","model_system":"Metabolic syndrome; half-cup-equivalent arm; six months.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b08e7f7d-4d34-56d7-a185-2124f8d72b3c","stable_key":"import-35ec55a7-323c-5c28-979e-3bdafe9d5769","title":"Anthocyanins: detailed mechanisms of action (reviewed 4 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"7cff1a47fbd9c625412b84162b1c823004b4162b7c009f9a11d5807fb8e04ef9","revision_id":"1bd4fa42-bfeb-5148-8250-fc363d8c1de0","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}