Coffee chlorogenic-acid mixture, composition study-specific

evidence_span

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experimental_model

HPLC-MS3 human ileostomy study with intact-colon comparison from another study

exposure

200 mL instant coffee containing 385 micromol total chlorogenic acids

limitations

Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal.

nutrient_topic

Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid

organism

Human

plain_language

This conjugated metabolite is searchable separately from the swallowed parent.

primary_references

[chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. (2010). https://pubmed.ncbi.nlm.nih.gov/20226754/ DOI: 10.1016/j.abb.2010.03.005

tissue_or_cell_type

Ileal effluent and 24-hour urine

Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 269–280

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · HPLC-MS3 human ileostomy study with intact-colon comparison from another study · source_derived_draft · unverified_draft

### chlorogenic_acid-caffeic-sulfate Urine contained caffeic acid 3-O-sulfate after the coffee intervention. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: This conjugated metabolite is searchable separately from the swallowed parent. organism: Human tissue_or_cell_type: Ileal effluent and 24-hour urine experimental_model: HPLC-MS3 human ileostomy study with intact-colon comparison from another study limitations: Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal. exposure: 200 mL instant coffee containing 385 micromol total chlorogenic acids evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/20226754.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039", "start_char": 0, "end_char": 1482, "text_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039"} [chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. (2010). https://pubmed.ncbi.nlm.nih.gov/20226754/ DOI: 10.1016/j.abb.2010.03.005

evidence_span

{"source_cache": "artifacts/chlorogenic_acid-research/28012692.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "78c6f096f5e1ec58c1a1c2a7aacda48cadf220053e0f7bff5962c93188429d03", "start_char": 0, "end_char": 1766, "text_sha256": "78c6f096f5e1ec58c1a1c2a7aacda48cadf220053e0f7bff5962c93188429d03"}

experimental_model

Two acute randomized controlled crossover trials

exposure

Coffee with 89 or 310 mg CGAs, matched caffeine, n=15; pure 5-CQA 450/900 mg, n=24

limitations

Coffee is a mixture. Parallel metabolite timing is not proof that a specific metabolite caused dilation. The pure-compound P=0.06 result did not meet the conventional P<0.05 threshold.

nutrient_topic

Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid

organism

Human healthy men

plain_language

A coffee result includes the beverage matrix.

primary_references

[chlorogenic_acid-p28012692] Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials. (2017). https://pubmed.ncbi.nlm.nih.gov/28012692/ DOI: 10.1016/j.clnu.2016.11.013

tissue_or_cell_type

Brachial FMD and plasma metabolites

Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 997–1008

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Two acute randomized controlled crossover trials · source_derived_draft · unverified_draft

### chlorogenic_acid-coffee-fmd Both coffee formulations produced biphasic FMD increases accompanied by circulating CGA metabolites. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: A coffee result includes the beverage matrix. organism: Human healthy men tissue_or_cell_type: Brachial FMD and plasma metabolites experimental_model: Two acute randomized controlled crossover trials limitations: Coffee is a mixture. Parallel metabolite timing is not proof that a specific metabolite caused dilation. The pure-compound P=0.06 result did not meet the conventional P<0.05 threshold. exposure: Coffee with 89 or 310 mg CGAs, matched caffeine, n=15; pure 5-CQA 450/900 mg, n=24 evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/28012692.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "78c6f096f5e1ec58c1a1c2a7aacda48cadf220053e0f7bff5962c93188429d03", "start_char": 0, "end_char": 1766, "text_sha256": "78c6f096f5e1ec58c1a1c2a7aacda48cadf220053e0f7bff5962c93188429d03"} [chlorogenic_acid-p28012692] Mediation of coffee-induced improvements in human vascular function by chlorogenic acids and its metabolites: Two randomized, controlled, crossover intervention trials. (2017). https://pubmed.ncbi.nlm.nih.gov/28012692/ DOI: 10.1016/j.clnu.2016.11.013

availability_state

machinery_impairment Imported condition classification; unverified.

evidence_span

{"source_cache": "artifacts/chlorogenic_acid-research/20226754.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039", "start_char": 0, "end_char": 1482, "text_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039"}

experimental_model

HPLC-MS3 human ileostomy study with intact-colon comparison from another study

exposure

200 mL instant coffee containing 385 micromol total chlorogenic acids

limitations

Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal.

nutrient_topic

Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid

organism

Human

plain_language

Microbial processing changes which compounds appear after ingestion.

primary_references

[chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. (2010). https://pubmed.ncbi.nlm.nih.gov/20226754/ DOI: 10.1016/j.abb.2010.03.005

tissue_or_cell_type

Ileal effluent and 24-hour urine

trigger_kind

machinery_impairment Imported condition classification; unverified.

Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 308–319

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · HPLC-MS3 human ileostomy study with intact-colon comparison from another study · source_derived_draft · unverified_draft

### chlorogenic_acid-colon-context Urinary recovery was 8 +/- 1% in ileostomy participants versus 29 +/- 4% in the intact-colon comparison; dihydroferulic acid and feruloylglycine were higher with an intact colon. Condition category: machinery_impairment nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Microbial processing changes which compounds appear after ingestion. organism: Human tissue_or_cell_type: Ileal effluent and 24-hour urine experimental_model: HPLC-MS3 human ileostomy study with intact-colon comparison from another study limitations: Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal. exposure: 200 mL instant coffee containing 385 micromol total chlorogenic acids evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/20226754.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039", "start_char": 0, "end_char": 1482, "text_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039"} [chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. (2010). https://pubmed.ncbi.nlm.nih.gov/20226754/ DOI: 10.1016/j.abb.2010.03.005

evidence_span

{"source_cache": "artifacts/chlorogenic_acid-research/20226754.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039", "start_char": 0, "end_char": 1482, "text_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039"}

experimental_model

HPLC-MS3 human ileostomy study with intact-colon comparison from another study

exposure

200 mL instant coffee containing 385 micromol total chlorogenic acids

limitations

Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal.

nutrient_topic

Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid

organism

Human

plain_language

This conjugated metabolite is searchable separately from the swallowed parent.

primary_references

[chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. (2010). https://pubmed.ncbi.nlm.nih.gov/20226754/ DOI: 10.1016/j.abb.2010.03.005

tissue_or_cell_type

Ileal effluent and 24-hour urine

Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 295–306

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · HPLC-MS3 human ileostomy study with intact-colon comparison from another study · source_derived_draft · unverified_draft

### chlorogenic_acid-dihydrocaffeic-sulfate Urine contained dihydrocaffeic acid 3-O-sulfate after the coffee intervention. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: This conjugated metabolite is searchable separately from the swallowed parent. organism: Human tissue_or_cell_type: Ileal effluent and 24-hour urine experimental_model: HPLC-MS3 human ileostomy study with intact-colon comparison from another study limitations: Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal. exposure: 200 mL instant coffee containing 385 micromol total chlorogenic acids evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/20226754.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039", "start_char": 0, "end_char": 1482, "text_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039"} [chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. (2010). https://pubmed.ncbi.nlm.nih.gov/20226754/ DOI: 10.1016/j.abb.2010.03.005

evidence_span

{"source_cache": "artifacts/chlorogenic_acid-research/22945604.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "84ce10a9298fba5308e7f9248e1dc96cc7663f13aefaa93f75e58881d6bd1d20", "start_char": 0, "end_char": 1470, "text_sha256": "84ce10a9298fba5308e7f9248e1dc96cc7663f13aefaa93f75e58881d6bd1d20"}

experimental_model

Randomized double-blind crossover dose-response study in ileostomy volunteers

exposure

Coffee with 1053, 2219 or 4525 micromol total CGAs

limitations

Coffee-mixture pharmacokinetics in ileostomy participants; deconjugated analytical totals are not free-parent concentrations or clinical efficacy.

nutrient_topic

Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid

organism

Human

plain_language

Doubling the swallowed amount need not double the recovered fraction.

primary_references

[chlorogenic_acid-p22945604] Dose-dependent absorption of chlorogenic acids in the small intestine assessed by coffee consumption in ileostomists. (2012). https://pubmed.ncbi.nlm.nih.gov/22945604/ DOI: 10.1002/mnfr.201200222

tissue_or_cell_type

Plasma, urine and ileal fluid

Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 321–332

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized double-blind crossover dose-response study in ileostomy volunteers · source_derived_draft · unverified_draft

### chlorogenic_acid-dose-recovery Urinary CGA/metabolite recovery fell from 14.6% to 12.1% to 8.0% of intake across increasing doses. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Doubling the swallowed amount need not double the recovered fraction. organism: Human tissue_or_cell_type: Plasma, urine and ileal fluid experimental_model: Randomized double-blind crossover dose-response study in ileostomy volunteers limitations: Coffee-mixture pharmacokinetics in ileostomy participants; deconjugated analytical totals are not free-parent concentrations or clinical efficacy. exposure: Coffee with 1053, 2219 or 4525 micromol total CGAs evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/22945604.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "84ce10a9298fba5308e7f9248e1dc96cc7663f13aefaa93f75e58881d6bd1d20", "start_char": 0, "end_char": 1470, "text_sha256": "84ce10a9298fba5308e7f9248e1dc96cc7663f13aefaa93f75e58881d6bd1d20"} [chlorogenic_acid-p22945604] Dose-dependent absorption of chlorogenic acids in the small intestine assessed by coffee consumption in ileostomists. (2012). https://pubmed.ncbi.nlm.nih.gov/22945604/ DOI: 10.1002/mnfr.201200222

evidence_span

{"source_cache": "artifacts/chlorogenic_acid-research/20226754.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039", "start_char": 0, "end_char": 1482, "text_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039"}

experimental_model

HPLC-MS3 human ileostomy study with intact-colon comparison from another study

exposure

200 mL instant coffee containing 385 micromol total chlorogenic acids

limitations

Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal.

nutrient_topic

Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid

organism

Human

plain_language

This conjugated metabolite is searchable separately from the swallowed parent.

primary_references

[chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. (2010). https://pubmed.ncbi.nlm.nih.gov/20226754/ DOI: 10.1016/j.abb.2010.03.005

tissue_or_cell_type

Ileal effluent and 24-hour urine

Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 256–267

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · HPLC-MS3 human ileostomy study with intact-colon comparison from another study · source_derived_draft · unverified_draft

### chlorogenic_acid-ferulic-sulfate Urine contained ferulic acid 4-O-sulfate after the coffee intervention. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: This conjugated metabolite is searchable separately from the swallowed parent. organism: Human tissue_or_cell_type: Ileal effluent and 24-hour urine experimental_model: HPLC-MS3 human ileostomy study with intact-colon comparison from another study limitations: Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal. exposure: 200 mL instant coffee containing 385 micromol total chlorogenic acids evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/20226754.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039", "start_char": 0, "end_char": 1482, "text_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039"} [chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. (2010). https://pubmed.ncbi.nlm.nih.gov/20226754/ DOI: 10.1016/j.abb.2010.03.005

evidence_span

{"source_cache": "artifacts/chlorogenic_acid-research/20226754.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039", "start_char": 0, "end_char": 1482, "text_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039"}

experimental_model

HPLC-MS3 human ileostomy study with intact-colon comparison from another study

exposure

200 mL instant coffee containing 385 micromol total chlorogenic acids

limitations

Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal.

nutrient_topic

Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid

organism

Human

plain_language

A large chemical load remained available for colonic processing.

primary_references

[chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. (2010). https://pubmed.ncbi.nlm.nih.gov/20226754/ DOI: 10.1016/j.abb.2010.03.005

tissue_or_cell_type

Ileal effluent and 24-hour urine

Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 243–254

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · HPLC-MS3 human ileostomy study with intact-colon comparison from another study · source_derived_draft · unverified_draft

### chlorogenic_acid-ileal-recovery Ileal compounds accounted for 71 +/- 7% of intake; 78% of recovered material was parent compounds and 22% metabolites. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: A large chemical load remained available for colonic processing. organism: Human tissue_or_cell_type: Ileal effluent and 24-hour urine experimental_model: HPLC-MS3 human ileostomy study with intact-colon comparison from another study limitations: Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal. exposure: 200 mL instant coffee containing 385 micromol total chlorogenic acids evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/20226754.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039", "start_char": 0, "end_char": 1482, "text_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039"} [chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. (2010). https://pubmed.ncbi.nlm.nih.gov/20226754/ DOI: 10.1016/j.abb.2010.03.005

evidence_span

{"source_cache": "artifacts/chlorogenic_acid-research/20226754.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039", "start_char": 0, "end_char": 1482, "text_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039"}

experimental_model

HPLC-MS3 human ileostomy study with intact-colon comparison from another study

exposure

200 mL instant coffee containing 385 micromol total chlorogenic acids

limitations

Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal.

nutrient_topic

Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid

organism

Human

plain_language

This conjugated metabolite is searchable separately from the swallowed parent.

primary_references

[chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. (2010). https://pubmed.ncbi.nlm.nih.gov/20226754/ DOI: 10.1016/j.abb.2010.03.005

tissue_or_cell_type

Ileal effluent and 24-hour urine

Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 282–293

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · HPLC-MS3 human ileostomy study with intact-colon comparison from another study · source_derived_draft · unverified_draft

### chlorogenic_acid-isoferulic-glucuronide Urine contained isoferulic acid 3-O-glucuronide after the coffee intervention. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: This conjugated metabolite is searchable separately from the swallowed parent. organism: Human tissue_or_cell_type: Ileal effluent and 24-hour urine experimental_model: HPLC-MS3 human ileostomy study with intact-colon comparison from another study limitations: Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal. exposure: 200 mL instant coffee containing 385 micromol total chlorogenic acids evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/20226754.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039", "start_char": 0, "end_char": 1482, "text_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039"} [chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. (2010). https://pubmed.ncbi.nlm.nih.gov/20226754/ DOI: 10.1016/j.abb.2010.03.005

evidence_span

{"source_cache": "artifacts/chlorogenic_acid-research/30326634.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "47354c1e3ee8848928923eabc23556d56e71fa1cda32d63a59d2b45f0fb24517", "start_char": 0, "end_char": 2069, "text_sha256": "47354c1e3ee8848928923eabc23556d56e71fa1cda32d63a59d2b45f0fb24517"}

experimental_model

LC-electrochemical assay validated by high-resolution mass spectrometry

exposure

Three caffeoylquinic-acid standards; eight coffee species and two harvest periods

limitations

Chemical identity and food composition, not a human intervention. The numbering convention is explicit because historical 3/5 naming can be reversed.

nutrient_topic

Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid

organism

Coffea species

plain_language

A plant name does not specify a reproducible dose.

primary_references

[chlorogenic_acid-p30326634] Determination of Three Main Chlorogenic Acids in Water Extracts of Coffee Leaves by Liquid Chromatography Coupled to an Electrochemical Detector. (2018). https://pubmed.ncbi.nlm.nih.gov/30326634/ DOI: 10.3390/antiox7100143

tissue_or_cell_type

Aqueous coffee-leaf extracts

Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 191–202

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · LC-electrochemical assay validated by high-resolution mass spectrometry · source_derived_draft · unverified_draft

### chlorogenic_acid-plant-composition 5-CQA was the major measured isomer in the studied leaf extracts; quantities varied by species and harvest. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: A plant name does not specify a reproducible dose. organism: Coffea species tissue_or_cell_type: Aqueous coffee-leaf extracts experimental_model: LC-electrochemical assay validated by high-resolution mass spectrometry limitations: Chemical identity and food composition, not a human intervention. The numbering convention is explicit because historical 3/5 naming can be reversed. exposure: Three caffeoylquinic-acid standards; eight coffee species and two harvest periods evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/30326634.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "47354c1e3ee8848928923eabc23556d56e71fa1cda32d63a59d2b45f0fb24517", "start_char": 0, "end_char": 2069, "text_sha256": "47354c1e3ee8848928923eabc23556d56e71fa1cda32d63a59d2b45f0fb24517"} [chlorogenic_acid-p30326634] Determination of Three Main Chlorogenic Acids in Water Extracts of Coffee Leaves by Liquid Chromatography Coupled to an Electrochemical Detector. (2018). https://pubmed.ncbi.nlm.nih.gov/30326634/ DOI: 10.3390/antiox7100143

evidence_span

{"source_cache": "artifacts/chlorogenic_acid-research/36501092.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dcd5f0afb16bd6f9c61c91be9220e18751e0e34c8eac1aeeb5613649ed2d001b", "start_char": 0, "end_char": 1425, "text_sha256": "dcd5f0afb16bd6f9c61c91be9220e18751e0e34c8eac1aeeb5613649ed2d001b"}

experimental_model

Randomized crossover beverage intervention in 11 men

exposure

Three weeks: 620 mg green tea catechins plus 373 mg CGAs plus 119 mg caffeine; control 119 mg caffeine

limitations

A multi-ingredient formulation with a small sample. Effects cannot be assigned to CGA alone or treated as a contradiction of an acute isolated-CGA experiment.

nutrient_topic

Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid

organism

Human

plain_language

Different incretins responded in different directions.

primary_references

[chlorogenic_acid-p36501092] Effects of Ingesting Both Catechins and Chlorogenic Acids on Glucose, Incretin, and Insulin Sensitivity in Healthy Men: A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial. (2022). https://pubmed.ncbi.nlm.nih.gov/36501092/ DOI: 10.3390/nu14235063

tissue_or_cell_type

Postprandial glucose, insulin and incretin measurements

Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 1075–1086

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized crossover beverage intervention in 11 men · source_derived_draft · unverified_draft

### chlorogenic_acid-mixture-gip The combined beverage reduced postprandial GIP. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: Different incretins responded in different directions. organism: Human tissue_or_cell_type: Postprandial glucose, insulin and incretin measurements experimental_model: Randomized crossover beverage intervention in 11 men limitations: A multi-ingredient formulation with a small sample. Effects cannot be assigned to CGA alone or treated as a contradiction of an acute isolated-CGA experiment. exposure: Three weeks: 620 mg green tea catechins plus 373 mg CGAs plus 119 mg caffeine; control 119 mg caffeine evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/36501092.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dcd5f0afb16bd6f9c61c91be9220e18751e0e34c8eac1aeeb5613649ed2d001b", "start_char": 0, "end_char": 1425, "text_sha256": "dcd5f0afb16bd6f9c61c91be9220e18751e0e34c8eac1aeeb5613649ed2d001b"} [chlorogenic_acid-p36501092] Effects of Ingesting Both Catechins and Chlorogenic Acids on Glucose, Incretin, and Insulin Sensitivity in Healthy Men: A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial. (2022). https://pubmed.ncbi.nlm.nih.gov/36501092/ DOI: 10.3390/nu14235063

evidence_span

{"source_cache": "artifacts/chlorogenic_acid-research/36501092.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dcd5f0afb16bd6f9c61c91be9220e18751e0e34c8eac1aeeb5613649ed2d001b", "start_char": 0, "end_char": 1425, "text_sha256": "dcd5f0afb16bd6f9c61c91be9220e18751e0e34c8eac1aeeb5613649ed2d001b"}

experimental_model

Randomized crossover beverage intervention in 11 men

exposure

Three weeks: 620 mg green tea catechins plus 373 mg CGAs plus 119 mg caffeine; control 119 mg caffeine

limitations

A multi-ingredient formulation with a small sample. Effects cannot be assigned to CGA alone or treated as a contradiction of an acute isolated-CGA experiment.

nutrient_topic

Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid

organism

Human

plain_language

The complete tested combination is the exposure.

primary_references

[chlorogenic_acid-p36501092] Effects of Ingesting Both Catechins and Chlorogenic Acids on Glucose, Incretin, and Insulin Sensitivity in Healthy Men: A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial. (2022). https://pubmed.ncbi.nlm.nih.gov/36501092/ DOI: 10.3390/nu14235063

tissue_or_cell_type

Postprandial glucose, insulin and incretin measurements

Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 1062–1073

AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · Randomized crossover beverage intervention in 11 men · source_derived_draft · unverified_draft

### chlorogenic_acid-mixture-glp1 The combined beverage increased postprandial GLP-1 relative to its caffeine control. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: The complete tested combination is the exposure. organism: Human tissue_or_cell_type: Postprandial glucose, insulin and incretin measurements experimental_model: Randomized crossover beverage intervention in 11 men limitations: A multi-ingredient formulation with a small sample. Effects cannot be assigned to CGA alone or treated as a contradiction of an acute isolated-CGA experiment. exposure: Three weeks: 620 mg green tea catechins plus 373 mg CGAs plus 119 mg caffeine; control 119 mg caffeine evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/36501092.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "dcd5f0afb16bd6f9c61c91be9220e18751e0e34c8eac1aeeb5613649ed2d001b", "start_char": 0, "end_char": 1425, "text_sha256": "dcd5f0afb16bd6f9c61c91be9220e18751e0e34c8eac1aeeb5613649ed2d001b"} [chlorogenic_acid-p36501092] Effects of Ingesting Both Catechins and Chlorogenic Acids on Glucose, Incretin, and Insulin Sensitivity in Healthy Men: A Randomized, Double-Blinded, Placebo-Controlled Crossover Trial. (2022). https://pubmed.ncbi.nlm.nih.gov/36501092/ DOI: 10.3390/nu14235063