{"id":"ab104d24-5e37-53b1-9d67-0e75a1cdabd8","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-caffeic-sulfate","predicate":"yielded_urinary","statement":"Urine contained caffeic acid 3-O-sulfate after the coffee intervention.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6b3e989b-0d60-57a8-be00-3e31f675f9da","mechanism_event_label":"This conjugated metabolite is searchable separately from the swallowed parent.","subject":{"id":"c9bbdf31-4e82-56f9-8935-7aceb2ae56fa","slug":"coffee-chlorogenic-acid-mixture","display_name":"Coffee chlorogenic-acid mixture, composition study-specific","entity_type_key":"chemical_species"},"object":{"id":"f2d6d972-4eba-5743-9110-31b0a5f8981b","slug":"caffeic-acid-3-o-sulfate","display_name":"Caffeic acid 3-O-sulfate","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"6b3e989b-0d60-57a8-be00-3e31f675f9da","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-caffeic-sulfate-event","event_type":"observed_intervention","label":"This conjugated metabolite is searchable separately from the swallowed parent.","description":"Urine contained caffeic acid 3-O-sulfate after the coffee intervention.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c9bbdf31-4e82-56f9-8935-7aceb2ae56fa","slug":"coffee-chlorogenic-acid-mixture","display_name":"Coffee chlorogenic-acid mixture, composition study-specific","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"f2d6d972-4eba-5743-9110-31b0a5f8981b","slug":"caffeic-acid-3-o-sulfate","display_name":"Caffeic acid 3-O-sulfate","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chlorogenic_acid-research/20226754.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039\", \"start_char\": 0, \"end_char\": 1482, \"text_sha256\": \"c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"HPLC-MS3 human ileostomy study with intact-colon comparison from another study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"200 mL instant coffee containing 385 micromol total chlorogenic acids","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This conjugated metabolite is searchable separately from the swallowed parent.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. (2010). https://pubmed.ncbi.nlm.nih.gov/20226754/ DOI: 10.1016/j.abb.2010.03.005","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Ileal effluent and 24-hour urine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0f9bc89c-a68c-503c-891f-f3a737c9f479","evidence_kind":"source_excerpt","locator":"Lines 269-280","start_line":269,"end_line":280,"excerpt":"### chlorogenic_acid-caffeic-sulfate\nUrine contained caffeic acid 3-O-sulfate after the coffee intervention.\nCondition category: normal\nnutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This conjugated metabolite is searchable separately from the swallowed parent.\norganism: Human\ntissue_or_cell_type: Ileal effluent and 24-hour urine\nexperimental_model: HPLC-MS3 human ileostomy study with intact-colon comparison from another study\nlimitations: Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal.\nexposure: 200 mL instant coffee containing 385 micromol total chlorogenic acids\nevidence_span: {\"source_cache\": \"artifacts/chlorogenic_acid-research/20226754.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039\", \"start_char\": 0, \"end_char\": 1482, \"text_sha256\": \"c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039\"}\n[chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. 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