{"id":"3b0ad178-d35d-5438-b81f-b0698798668f","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-dose-recovery","predicate":"showed_dose_dependent","statement":"Urinary CGA/metabolite recovery fell from 14.6% to 12.1% to 8.0% of intake across increasing doses.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"f89bef97-eb92-51cc-9843-f28317c8d2b2","mechanism_event_label":"Doubling the swallowed amount need not double the recovered fraction.","subject":{"id":"c9bbdf31-4e82-56f9-8935-7aceb2ae56fa","slug":"coffee-chlorogenic-acid-mixture","display_name":"Coffee chlorogenic-acid mixture, composition study-specific","entity_type_key":"chemical_species"},"object":{"id":"552d7357-d9bb-5d3c-81be-ac90ac709c85","slug":"cga-urinary-metabolite-recovery","display_name":"Urinary recovery of chlorogenic-acid-related metabolites","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"f89bef97-eb92-51cc-9843-f28317c8d2b2","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-dose-recovery-event","event_type":"observed_intervention","label":"Doubling the swallowed amount need not double the recovered fraction.","description":"Urinary CGA/metabolite recovery fell from 14.6% to 12.1% to 8.0% of intake across increasing doses.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c9bbdf31-4e82-56f9-8935-7aceb2ae56fa","slug":"coffee-chlorogenic-acid-mixture","display_name":"Coffee chlorogenic-acid mixture, composition study-specific","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"552d7357-d9bb-5d3c-81be-ac90ac709c85","slug":"cga-urinary-metabolite-recovery","display_name":"Urinary recovery of chlorogenic-acid-related metabolites","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chlorogenic_acid-research/22945604.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"84ce10a9298fba5308e7f9248e1dc96cc7663f13aefaa93f75e58881d6bd1d20\", \"start_char\": 0, \"end_char\": 1470, \"text_sha256\": \"84ce10a9298fba5308e7f9248e1dc96cc7663f13aefaa93f75e58881d6bd1d20\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized double-blind crossover dose-response study in ileostomy volunteers","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"Coffee with 1053, 2219 or 4525 micromol total CGAs","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Coffee-mixture pharmacokinetics in ileostomy participants; deconjugated analytical totals are not free-parent concentrations or clinical efficacy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Doubling the swallowed amount need not double the recovered fraction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chlorogenic_acid-p22945604] Dose-dependent absorption of chlorogenic acids in the small intestine assessed by coffee consumption in ileostomists. 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