Component
Chlorogenic-acid compounds recovered in ileal effluent
Chlorogenic-acid compounds recovered in ileal effluent. Species, exposure and limitations are retained in each linked claim.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Ileal compounds accounted for 71 +/- 7% of intake; 78% of recovered material was parent compounds and 22% metabolites.
Experimental context and source evidence
- evidence_span
- {"source_cache": "artifacts/chlorogenic_acid-research/20226754.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039", "start_char": 0, "end_char": 1482, "text_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039"}
- experimental_model
- HPLC-MS3 human ileostomy study with intact-colon comparison from another study
- exposure
- 200 mL instant coffee containing 385 micromol total chlorogenic acids
- limitations
- Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal.
- nutrient_topic
- Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. · Chlorogenic acid / 5-O-caffeoylquinic acid
- organism
- Human
- plain_language
- A large chemical load remained available for colonic processing.
- primary_references
- [chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. (2010). https://pubmed.ncbi.nlm.nih.gov/20226754/ DOI: 10.1016/j.abb.2010.03.005
- tissue_or_cell_type
- Ileal effluent and 24-hour urine
Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17) · lines 243–254
AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text. · supports · HPLC-MS3 human ileostomy study with intact-colon comparison from another study · source_derived_draft · unverified_draft
### chlorogenic_acid-ileal-recovery Ileal compounds accounted for 71 +/- 7% of intake; 78% of recovered material was parent compounds and 22% metabolites. Condition category: normal nutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect. plain_language: A large chemical load remained available for colonic processing. organism: Human tissue_or_cell_type: Ileal effluent and 24-hour urine experimental_model: HPLC-MS3 human ileostomy study with intact-colon comparison from another study limitations: Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal. exposure: 200 mL instant coffee containing 385 micromol total chlorogenic acids evidence_span: {"source_cache": "artifacts/chlorogenic_acid-research/20226754.abstract.txt", "locator": "Primary indexed abstract; zero-based, end-exclusive Unicode character offsets", "file_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039", "start_char": 0, "end_char": 1482, "text_sha256": "c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039"} [chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. (2010). https://pubmed.ncbi.nlm.nih.gov/20226754/ DOI: 10.1016/j.abb.2010.03.005
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.