{"id":"e46ae2bb-7c88-5cf2-863e-2de752eac31a","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-colon-context","predicate":"showed_context_dependent","statement":"Urinary recovery was 8 +/- 1% in ileostomy participants versus 29 +/- 4% in the intact-colon comparison; dihydroferulic acid and feruloylglycine were higher with an intact colon.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8436e758-67c4-5daf-9b91-241b312bfc28","mechanism_event_label":"Microbial processing changes which compounds appear after ingestion.","subject":{"id":"c9bbdf31-4e82-56f9-8935-7aceb2ae56fa","slug":"coffee-chlorogenic-acid-mixture","display_name":"Coffee chlorogenic-acid mixture, composition study-specific","entity_type_key":"chemical_species"},"object":{"id":"552d7357-d9bb-5d3c-81be-ac90ac709c85","slug":"cga-urinary-metabolite-recovery","display_name":"Urinary recovery of chlorogenic-acid-related metabolites","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"8436e758-67c4-5daf-9b91-241b312bfc28","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-colon-context-event","event_type":"observed_intervention","label":"Microbial processing changes which compounds appear after ingestion.","description":"Urinary recovery was 8 +/- 1% in ileostomy participants versus 29 +/- 4% in the intact-colon comparison; dihydroferulic acid and feruloylglycine were higher with an intact colon.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"75e012e8-a9c3-50de-a70e-59095ff820e4","slug":"dihydroferulic-acid","display_name":"Dihydroferulic acid","entity_type_key":"small_molecule"},"role":"colon_associated_metabolite","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"acbf55ea-1e13-59d9-bcdf-63790b676079","slug":"feruloylglycine","display_name":"Feruloylglycine","entity_type_key":"small_molecule"},"role":"colon_associated_metabolite","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c9bbdf31-4e82-56f9-8935-7aceb2ae56fa","slug":"coffee-chlorogenic-acid-mixture","display_name":"Coffee chlorogenic-acid mixture, composition study-specific","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"552d7357-d9bb-5d3c-81be-ac90ac709c85","slug":"cga-urinary-metabolite-recovery","display_name":"Urinary recovery of chlorogenic-acid-related metabolites","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"availability_state","value_text":"machinery_impairment","comparator":null,"unit":null,"notes":"Imported condition classification; unverified.","entity":null},{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chlorogenic_acid-research/20226754.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039\", \"start_char\": 0, \"end_char\": 1482, \"text_sha256\": \"c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"HPLC-MS3 human ileostomy study with intact-colon comparison from another study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"200 mL instant coffee containing 385 micromol total chlorogenic acids","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"Microbial processing changes which compounds appear after ingestion.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. 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Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal.\nexposure: 200 mL instant coffee containing 385 micromol total chlorogenic acids\nevidence_span: {\"source_cache\": \"artifacts/chlorogenic_acid-research/20226754.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039\", \"start_char\": 0, \"end_char\": 1482, \"text_sha256\": \"c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039\"}\n[chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. 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