{"id":"c8c810f6-8256-5270-8ca0-cb4086e8c6ed","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-isoferulic-glucuronide","predicate":"yielded_urinary","statement":"Urine contained isoferulic acid 3-O-glucuronide after the coffee intervention.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"8e38f90a-383a-5c73-87dd-059cb0a1b8a4","mechanism_event_label":"This conjugated metabolite is searchable separately from the swallowed parent.","subject":{"id":"c9bbdf31-4e82-56f9-8935-7aceb2ae56fa","slug":"coffee-chlorogenic-acid-mixture","display_name":"Coffee chlorogenic-acid mixture, composition study-specific","entity_type_key":"chemical_species"},"object":{"id":"61ee9ea5-61a9-5002-851f-4f2c492dd776","slug":"isoferulic-acid-3-o-glucuronide","display_name":"Isoferulic acid 3-O-glucuronide","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"8e38f90a-383a-5c73-87dd-059cb0a1b8a4","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-isoferulic-glucuronide-event","event_type":"observed_intervention","label":"This conjugated metabolite is searchable separately from the swallowed parent.","description":"Urine contained isoferulic acid 3-O-glucuronide after the coffee intervention.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"c9bbdf31-4e82-56f9-8935-7aceb2ae56fa","slug":"coffee-chlorogenic-acid-mixture","display_name":"Coffee chlorogenic-acid mixture, composition study-specific","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"61ee9ea5-61a9-5002-851f-4f2c492dd776","slug":"isoferulic-acid-3-o-glucuronide","display_name":"Isoferulic acid 3-O-glucuronide","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chlorogenic_acid-research/20226754.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039\", \"start_char\": 0, \"end_char\": 1482, \"text_sha256\": \"c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"HPLC-MS3 human ileostomy study with intact-colon comparison from another study","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"200 mL instant coffee containing 385 micromol total chlorogenic acids","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"This conjugated metabolite is searchable separately from the swallowed parent.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. (2010). https://pubmed.ncbi.nlm.nih.gov/20226754/ DOI: 10.1016/j.abb.2010.03.005","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Ileal effluent and 24-hour urine","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"1eacff36-ba41-5234-b092-a9fe77f618d1","evidence_kind":"source_excerpt","locator":"Lines 282-293","start_line":282,"end_line":293,"excerpt":"### chlorogenic_acid-isoferulic-glucuronide\nUrine contained isoferulic acid 3-O-glucuronide after the coffee intervention.\nCondition category: normal\nnutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: This conjugated metabolite is searchable separately from the swallowed parent.\norganism: Human\ntissue_or_cell_type: Ileal effluent and 24-hour urine\nexperimental_model: HPLC-MS3 human ileostomy study with intact-colon comparison from another study\nlimitations: Coffee is a mixture. Urinary metabolites do not identify the responsible SULT/UGT isoform or prove target-tissue parent exposure. The intact-colon comparison is across studies, not randomized colon removal.\nexposure: 200 mL instant coffee containing 385 micromol total chlorogenic acids\nevidence_span: {\"source_cache\": \"artifacts/chlorogenic_acid-research/20226754.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039\", \"start_char\": 0, \"end_char\": 1482, \"text_sha256\": \"c31893938a2502d4602a25abb05dfc09a67d88926ead9ca63adf0b4391d55039\"}\n[chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. (2010). https://pubmed.ncbi.nlm.nih.gov/20226754/ DOI: 10.1016/j.abb.2010.03.005","model_system":"HPLC-MS3 human ileostomy study with intact-colon comparison from another study","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [chlorogenic_acid-p20226754] Bioavailability of chlorogenic acids following acute ingestion of coffee by humans with an ileostomy. (2010). https://pubmed.ncbi.nlm.nih.gov/20226754/ DOI: 10.1016/j.abb.2010.03.005","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"98a7cb8d-1d80-5cfe-9690-4068d21878e3","stable_key":"import-00c24cfe-6189-5244-b81f-5d693e4e177d","title":"Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. 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