Component

Blueberry powder standardized to half- or one-cup equivalents in Curtis 2019

Blueberry powder standardized to half- or one-cup equivalents in Curtis 2019. Interpret through the linked experimental species, preparation, compartment and exposure; no universal causal effect is implied.

4 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Half-cup-equivalent blueberry intake did not improve FMD in the six-month trial.

    Blueberry powder standardized to half- or one-cup equivalents in Curtis 2019 → Brachial artery flow-mediated dilation source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Full text retrieved; relevant methods/results/figure text reviewed. No independent raw-data verification.
    experimental_contrast
    {"intervention": "Half-cup-equivalent blueberry powder daily", "comparator": "Matched placebo", "endpoint": "Half-cup-equivalent blueberry intake did not improve FMD in the six-month trial.", "effect_direction": "no_detected_change", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    Metabolic syndrome; half-cup-equivalent arm; six months.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Does not establish a universal daily-dose threshold.
    plain_language
    Half-cup-equivalent blueberry intake did not improve FMD in the six-month trial.
    primary_references
    Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial. | 2019 | DOI 10.1093/ajcn/nqy380 | PMID 31136659 | https://pubmed.ncbi.nlm.nih.gov/31136659/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6537945/ | https://doi.org/10.1093/ajcn/nqy380
    source_locator
    Reviewed reference lines 62-62; exact primary location described in quoted passage where extracted.

    Anthocyanins: detailed mechanisms of action (reviewed 4 October 2026) · lines 62–62

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Metabolic syndrome; half-cup-equivalent arm; six months. · source_derived_draft · unverified_draft

    **Clinical nulls remain part of the mechanism reference.** In 115 adults with metabolic syndrome completing a six-month randomized blueberry trial, one-cup-equivalent intake improved FMD, but insulin resistance, blood pressure, pulse-wave velocity, NO and overall plasma thiol status did not significantly improve. Half-cup-equivalent intake did not improve the reported biomarkers. These results do not contradict every short-term purified-compound study; they constrain extrapolation across preparations, durations and endpoints. [Curtis et al., 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6537945/). Its corrigendum changes the insulin unit in Table 2 to mU/L; it does not announce a reversal of the trial's outcomes. [Publisher correction](https://pmc.ncbi.nlm.nih.gov/articles/PMC6821540/).
    Complete structured claim and evidence

  2. One-cup-equivalent daily blueberry powder improved FMD in the six-month metabolic-syndrome trial.

    Blueberry powder standardized to half- or one-cup equivalents in Curtis 2019 → Brachial artery flow-mediated dilation source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Full text retrieved; relevant methods/results/figure text reviewed. No independent raw-data verification.
    experimental_contrast
    {"intervention": "One-cup-equivalent blueberry powder daily", "comparator": "Matched placebo for six months", "endpoint": "One-cup-equivalent daily blueberry powder improved FMD in the six-month metabolic-syndrome trial.", "effect_direction": "increase", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    115 completers; metabolic syndrome; six-month randomized trial; one-cup equivalent arm.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Whole-blueberry preparation, not isolated anthocyanins. Clinical event prevention was not measured; Table 2 insulin-unit corrigendum retained.
    plain_language
    One-cup-equivalent daily blueberry powder improved FMD in the six-month metabolic-syndrome trial.
    primary_references
    Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial. | 2019 | DOI 10.1093/ajcn/nqy380 | PMID 31136659 | https://pubmed.ncbi.nlm.nih.gov/31136659/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6537945/ | https://doi.org/10.1093/ajcn/nqy380
    source_locator
    Reviewed reference lines 62-62; exact primary location described in quoted passage where extracted.

    Anthocyanins: detailed mechanisms of action (reviewed 4 October 2026) · lines 62–62

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · 115 completers; metabolic syndrome; six-month randomized trial; one-cup equivalent arm. · source_derived_draft · unverified_draft

    **Clinical nulls remain part of the mechanism reference.** In 115 adults with metabolic syndrome completing a six-month randomized blueberry trial, one-cup-equivalent intake improved FMD, but insulin resistance, blood pressure, pulse-wave velocity, NO and overall plasma thiol status did not significantly improve. Half-cup-equivalent intake did not improve the reported biomarkers. These results do not contradict every short-term purified-compound study; they constrain extrapolation across preparations, durations and endpoints. [Curtis et al., 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6537945/). Its corrigendum changes the insulin unit in Table 2 to mU/L; it does not announce a reversal of the trial's outcomes. [Publisher correction](https://pmc.ncbi.nlm.nih.gov/articles/PMC6821540/).
    Complete structured claim and evidence

  3. Insulin resistance did not significantly improve in the six-month blueberry trial.

    Blueberry powder standardized to half- or one-cup equivalents in Curtis 2019 → HOMA-IR estimate of insulin resistance source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Full text retrieved; relevant methods/results/figure text reviewed. No independent raw-data verification.
    experimental_contrast
    {"intervention": "Daily blueberry powder", "comparator": "Matched placebo", "endpoint": "Insulin resistance did not significantly improve in the six-month blueberry trial.", "effect_direction": "no_detected_change", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    Adults with metabolic syndrome, six months; HOMA-IR primary endpoint.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Not proof of universal absence of metabolic effects; preparation, population and duration constrain interpretation. Corrigendum concerns insulin units, not reversal of outcome.
    plain_language
    Insulin resistance did not significantly improve in the six-month blueberry trial.
    primary_references
    Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial. | 2019 | DOI 10.1093/ajcn/nqy380 | PMID 31136659 | https://pubmed.ncbi.nlm.nih.gov/31136659/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6537945/ | https://doi.org/10.1093/ajcn/nqy380
    source_locator
    Reviewed reference lines 62-62; exact primary location described in quoted passage where extracted.

    Anthocyanins: detailed mechanisms of action (reviewed 4 October 2026) · lines 62–62

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Adults with metabolic syndrome, six months; HOMA-IR primary endpoint. · source_derived_draft · unverified_draft

    **Clinical nulls remain part of the mechanism reference.** In 115 adults with metabolic syndrome completing a six-month randomized blueberry trial, one-cup-equivalent intake improved FMD, but insulin resistance, blood pressure, pulse-wave velocity, NO and overall plasma thiol status did not significantly improve. Half-cup-equivalent intake did not improve the reported biomarkers. These results do not contradict every short-term purified-compound study; they constrain extrapolation across preparations, durations and endpoints. [Curtis et al., 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6537945/). Its corrigendum changes the insulin unit in Table 2 to mU/L; it does not announce a reversal of the trial's outcomes. [Publisher correction](https://pmc.ncbi.nlm.nih.gov/articles/PMC6821540/).
    Complete structured claim and evidence

What acts on it

  1. The specified preparation contains anthocyanins; its experimental effects remain attached to the actual preparation.

    Anthocyanins → Blueberry powder standardized to half- or one-cup equivalents in Curtis 2019 source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Full text retrieved; relevant methods/results/figure text reviewed. No independent raw-data verification.
    experimental_model
    Preparation identity/scope; not isolated class causation.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    A food or extract contains other constituents. Membership is a navigation link and does not transfer its findings to isolated anthocyanins.
    plain_language
    The specified preparation contains anthocyanins; its experimental effects remain attached to the actual preparation.
    primary_references
    Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial. | 2019 | DOI 10.1093/ajcn/nqy380 | PMID 31136659 | https://pubmed.ncbi.nlm.nih.gov/31136659/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6537945/ | https://doi.org/10.1093/ajcn/nqy380
    source_locator
    Reviewed reference lines 62-62; exact primary location described in quoted passage where extracted.

    Anthocyanins: detailed mechanisms of action (reviewed 4 October 2026) · lines 62–62

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Preparation identity/scope; not isolated class causation. · source_derived_draft · unverified_draft

    **Clinical nulls remain part of the mechanism reference.** In 115 adults with metabolic syndrome completing a six-month randomized blueberry trial, one-cup-equivalent intake improved FMD, but insulin resistance, blood pressure, pulse-wave velocity, NO and overall plasma thiol status did not significantly improve. Half-cup-equivalent intake did not improve the reported biomarkers. These results do not contradict every short-term purified-compound study; they constrain extrapolation across preparations, durations and endpoints. [Curtis et al., 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6537945/). Its corrigendum changes the insulin unit in Table 2 to mU/L; it does not announce a reversal of the trial's outcomes. [Publisher correction](https://pmc.ncbi.nlm.nih.gov/articles/PMC6821540/).
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.