{"id":"93756a8e-fefa-501f-b2d1-21c9e94521a9","stable_key":"35ec55a7-323c-5c28-979e-3bdafe9d5769:preparation-scope-blueberry-powder-curtis-2019","predicate":"present_in_specified_preparation","statement":"The specified preparation contains anthocyanins; its experimental effects remain attached to the actual preparation. ","claim_class":"identity","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"55273134-240e-59bd-92f1-d64d149dde40","mechanism_event_label":"The specified preparation contains anthocyanins; its experimental effects remain attached to the actual preparation. ","subject":{"id":"a1b1c9c3-cafe-5dd6-a590-f56222d3a4cc","slug":"anthocyanins","display_name":"Anthocyanins","entity_type_key":"chemical_species"},"object":{"id":"0d35d646-b792-5bce-84d0-0d09fb0aa0aa","slug":"blueberry-powder-curtis-2019","display_name":"Blueberry powder standardized to half- or one-cup equivalents in Curtis 2019","entity_type_key":"botanical"},"evidence_count":1,"mechanism_event":{"id":"55273134-240e-59bd-92f1-d64d149dde40","stable_key":"35ec55a7-323c-5c28-979e-3bdafe9d5769:preparation-scope-blueberry-powder-curtis-2019-event","event_type":"preparation_composition","label":"The specified preparation contains anthocyanins; its experimental effects remain attached to the actual preparation. ","description":"**Clinical nulls remain part of the mechanism reference.** In 115 adults with metabolic syndrome completing a six-month randomized blueberry trial, one-cup-equivalent intake improved FMD, but insulin resistance, blood pressure, pulse-wave velocity, NO and overall plasma thiol status did not significantly improve. Half-cup-equivalent intake did not improve the reported biomarkers. These results do not contradict every short-term purified-compound study; they constrain extrapolation across preparations, durations and endpoints. [Curtis et al., 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6537945/). Its corrigendum changes the insulin unit in Table 2 to mU/L; it does not announce a reversal of the trial's outcomes. [Publisher correction](https://pmc.ncbi.nlm.nih.gov/articles/PMC6821540/).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a1b1c9c3-cafe-5dd6-a590-f56222d3a4cc","slug":"anthocyanins","display_name":"Anthocyanins","entity_type_key":"chemical_species"},"role":"tested factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"0d35d646-b792-5bce-84d0-0d09fb0aa0aa","slug":"blueberry-powder-curtis-2019","display_name":"Blueberry powder standardized to half- or one-cup equivalents in Curtis 2019","entity_type_key":"botanical"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Full text retrieved; relevant methods/results/figure text reviewed. 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","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial. | 2019 | DOI 10.1093/ajcn/nqy380 | PMID 31136659 | https://pubmed.ncbi.nlm.nih.gov/31136659/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6537945/ | https://doi.org/10.1093/ajcn/nqy380","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 62-62; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"30a8a6b1-7354-5327-afb9-4d52954dd6e7","evidence_kind":"source_excerpt","locator":"Lines 62-62","start_line":62,"end_line":62,"excerpt":"**Clinical nulls remain part of the mechanism reference.** In 115 adults with metabolic syndrome completing a six-month randomized blueberry trial, one-cup-equivalent intake improved FMD, but insulin resistance, blood pressure, pulse-wave velocity, NO and overall plasma thiol status did not significantly improve. Half-cup-equivalent intake did not improve the reported biomarkers. These results do not contradict every short-term purified-compound study; they constrain extrapolation across preparations, durations and endpoints. [Curtis et al., 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6537945/). Its corrigendum changes the insulin unit in Table 2 to mU/L; it does not announce a reversal of the trial's outcomes. [Publisher correction](https://pmc.ncbi.nlm.nih.gov/articles/PMC6821540/).","model_system":"Preparation identity/scope; not isolated class causation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. 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