{"id":"ff98758f-f737-5219-9a47-85bad0c95f30","stable_key":"35ec55a7-323c-5c28-979e-3bdafe9d5769:longterm-blueberry-fmd","predicate":"increases_in_recorded_experiment","statement":"One-cup-equivalent daily blueberry powder improved FMD in the six-month metabolic-syndrome trial.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"c37975e4-1242-5262-b283-1eb0da01cac0","mechanism_event_label":"One-cup-equivalent daily blueberry powder improved FMD in the six-month metabolic-syndrome trial.","subject":{"id":"0d35d646-b792-5bce-84d0-0d09fb0aa0aa","slug":"blueberry-powder-curtis-2019","display_name":"Blueberry powder standardized to half- or one-cup equivalents in Curtis 2019","entity_type_key":"botanical"},"object":{"id":"a557fb69-ee27-5be9-8318-227c570267ff","slug":"flow-mediated-dilation","display_name":"Brachial artery flow-mediated dilation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c37975e4-1242-5262-b283-1eb0da01cac0","stable_key":"35ec55a7-323c-5c28-979e-3bdafe9d5769:longterm-blueberry-fmd-event","event_type":"experimental_observation","label":"One-cup-equivalent daily blueberry powder improved FMD in the six-month metabolic-syndrome trial.","description":"**Clinical nulls remain part of the mechanism reference.** In 115 adults with metabolic syndrome completing a six-month randomized blueberry trial, one-cup-equivalent intake improved FMD, but insulin resistance, blood pressure, pulse-wave velocity, NO and overall plasma thiol status did not significantly improve. Half-cup-equivalent intake did not improve the reported biomarkers. These results do not contradict every short-term purified-compound study; they constrain extrapolation across preparations, durations and endpoints. [Curtis et al., 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6537945/). Its corrigendum changes the insulin unit in Table 2 to mU/L; it does not announce a reversal of the trial's outcomes. [Publisher correction](https://pmc.ncbi.nlm.nih.gov/articles/PMC6821540/).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"0d35d646-b792-5bce-84d0-0d09fb0aa0aa","slug":"blueberry-powder-curtis-2019","display_name":"Blueberry powder standardized to half- or one-cup equivalents in Curtis 2019","entity_type_key":"botanical"},"role":"tested factor","stoichiometry":null,"state_label":"One-cup-equivalent blueberry powder daily","sequence_order":0,"notes":""},{"entity":{"id":"a557fb69-ee27-5be9-8318-227c570267ff","slug":"flow-mediated-dilation","display_name":"Brachial artery flow-mediated dilation","entity_type_key":"cellular_process"},"role":"measured outcome","stoichiometry":null,"state_label":"increase","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Full text retrieved; relevant methods/results/figure text reviewed. No independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_contrast","value_text":"{\"intervention\": \"One-cup-equivalent blueberry powder daily\", \"comparator\": \"Matched placebo for six months\", \"endpoint\": \"One-cup-equivalent daily blueberry powder improved FMD in the six-month metabolic-syndrome trial.\", \"effect_direction\": \"increase\", \"combination\": \"single\", \"conditions\": []}","comparator":null,"unit":null,"notes":"Explicit extracted experimental comparison; source-derived draft.","entity":null},{"dimension":"experimental_model","value_text":"115 completers; metabolic syndrome; six-month randomized trial; one-cup equivalent arm.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Whole-blueberry preparation, not isolated anthocyanins. Clinical event prevention was not measured; Table 2 insulin-unit corrigendum retained.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"One-cup-equivalent daily blueberry powder improved FMD in the six-month metabolic-syndrome trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Blueberries improve biomarkers of cardiometabolic function in participants with metabolic syndrome-results from a 6-month, double-blind, randomized controlled trial. | 2019 | DOI 10.1093/ajcn/nqy380 | PMID 31136659 | https://pubmed.ncbi.nlm.nih.gov/31136659/ | https://pmc.ncbi.nlm.nih.gov/articles/PMC6537945/ | https://doi.org/10.1093/ajcn/nqy380","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 62-62; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"6445dac1-5b12-5896-b165-34fc357e3405","evidence_kind":"source_excerpt","locator":"Lines 62-62","start_line":62,"end_line":62,"excerpt":"**Clinical nulls remain part of the mechanism reference.** In 115 adults with metabolic syndrome completing a six-month randomized blueberry trial, one-cup-equivalent intake improved FMD, but insulin resistance, blood pressure, pulse-wave velocity, NO and overall plasma thiol status did not significantly improve. Half-cup-equivalent intake did not improve the reported biomarkers. These results do not contradict every short-term purified-compound study; they constrain extrapolation across preparations, durations and endpoints. [Curtis et al., 2019](https://pmc.ncbi.nlm.nih.gov/articles/PMC6537945/). Its corrigendum changes the insulin unit in Table 2 to mU/L; it does not announce a reversal of the trial's outcomes. [Publisher correction](https://pmc.ncbi.nlm.nih.gov/articles/PMC6821540/).","model_system":"115 completers; metabolic syndrome; six-month randomized trial; one-cup equivalent arm.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b08e7f7d-4d34-56d7-a185-2124f8d72b3c","stable_key":"import-35ec55a7-323c-5c28-979e-3bdafe9d5769","title":"Anthocyanins: detailed mechanisms of action (reviewed 4 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"7cff1a47fbd9c625412b84162b1c823004b4162b7c009f9a11d5807fb8e04ef9","revision_id":"1bd4fa42-bfeb-5148-8250-fc363d8c1de0","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}