Component

Blueberry polyphenol drink in acute vascular studies

Blueberry polyphenol drink in acute vascular studies. Interpret through the linked experimental species, preparation, compartment and exposure; no universal causal effect is implied.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. Blueberry polyphenol intake increased FMD at 1-2 and 6 hours in the acute healthy-men crossover study.

    Blueberry polyphenol drink in acute vascular studies → Brachial artery flow-mediated dilation source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary indexed abstract reviewed; full methods, figures, exact doses or endpoint-specific species assignments may remain unextracted.
    experimental_contrast
    {"intervention": "Blueberry polyphenol drink", "comparator": "Macronutrient- and micronutrient-matched control drink", "endpoint": "Blueberry polyphenol intake increased FMD at 1-2 and 6 hours in the acute healthy-men crossover study.", "effect_direction": "increase", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    21 healthy men across acute time/intake studies; total-polyphenol plateau near 766 mg.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Dose is total polyphenols, not purified anthocyanins; no universal optimum or cardiovascular-event endpoint.
    plain_language
    Blueberry polyphenol intake increased FMD at 1-2 and 6 hours in the acute healthy-men crossover study.
    primary_references
    Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. | 2013 | DOI 10.3945/ajcn.113.066639 | PMID 24004888 | https://pubmed.ncbi.nlm.nih.gov/24004888/ | https://doi.org/10.3945/ajcn.113.066639
    source_locator
    Reviewed reference lines 54-54; exact primary location described in quoted passage where extracted.

    Anthocyanins: detailed mechanisms of action (reviewed 4 October 2026) · lines 54–54

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · 21 healthy men across acute time/intake studies; total-polyphenol plateau near 766 mg. · source_derived_draft · unverified_draft

    **Blueberry FMD timing tracks a changing exposure.** Acute crossover experiments in healthy men found FMD increases at 1–2 and six hours, associated with circulating phenolics and lower neutrophil NADPH-oxidase activity. A plateau occurred above roughly 766 mg of total blueberry polyphenols in that protocol. This was neither 766 mg purified anthocyanins nor a universal optimum. Neutrophil measurements cannot be relabeled direct endothelial NOX inhibition. [Rodriguez-Mateos et al., 2013](https://pubmed.ncbi.nlm.nih.gov/24004888/).
    Complete structured claim and evidence

  2. Acute blueberry polyphenol intake was associated with lower neutrophil NADPH oxidase activity at times of improved FMD.

    Blueberry polyphenol drink in acute vascular studies → Human neutrophil NADPH oxidase activity source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary indexed abstract reviewed; full methods, figures, exact doses or endpoint-specific species assignments may remain unextracted.
    experimental_contrast
    {"intervention": "Blueberry polyphenol drink", "comparator": "Matched control drink", "endpoint": "Acute blueberry polyphenol intake was associated with lower neutrophil NADPH oxidase activity at times of improved FMD.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
    experimental_model
    Healthy-men crossover studies; 1-2 and 6-hour sampling; measurements in neutrophils.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    Neutrophil assay and temporal association; not direct endothelial NOX binding or proof of mediation.
    plain_language
    Acute blueberry polyphenol intake was associated with lower neutrophil NADPH oxidase activity at times of improved FMD.
    primary_references
    Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. | 2013 | DOI 10.3945/ajcn.113.066639 | PMID 24004888 | https://pubmed.ncbi.nlm.nih.gov/24004888/ | https://doi.org/10.3945/ajcn.113.066639
    source_locator
    Reviewed reference lines 54-54; exact primary location described in quoted passage where extracted.

    Anthocyanins: detailed mechanisms of action (reviewed 4 October 2026) · lines 54–54

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Healthy-men crossover studies; 1-2 and 6-hour sampling; measurements in neutrophils. · source_derived_draft · unverified_draft

    **Blueberry FMD timing tracks a changing exposure.** Acute crossover experiments in healthy men found FMD increases at 1–2 and six hours, associated with circulating phenolics and lower neutrophil NADPH-oxidase activity. A plateau occurred above roughly 766 mg of total blueberry polyphenols in that protocol. This was neither 766 mg purified anthocyanins nor a universal optimum. Neutrophil measurements cannot be relabeled direct endothelial NOX inhibition. [Rodriguez-Mateos et al., 2013](https://pubmed.ncbi.nlm.nih.gov/24004888/).
    Complete structured claim and evidence

What acts on it

  1. The specified preparation contains anthocyanins; its experimental effects remain attached to the actual preparation.

    Anthocyanins → Blueberry polyphenol drink in acute vascular studies source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary indexed abstract reviewed; full methods, figures, exact doses or endpoint-specific species assignments may remain unextracted.
    experimental_model
    Preparation identity/scope; not isolated class causation.
    interpretation_status
    Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
    limitations
    A food or extract contains other constituents. Membership is a navigation link and does not transfer its findings to isolated anthocyanins.
    plain_language
    The specified preparation contains anthocyanins; its experimental effects remain attached to the actual preparation.
    primary_references
    Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. | 2013 | DOI 10.3945/ajcn.113.066639 | PMID 24004888 | https://pubmed.ncbi.nlm.nih.gov/24004888/ | https://doi.org/10.3945/ajcn.113.066639
    source_locator
    Reviewed reference lines 54-54; exact primary location described in quoted passage where extracted.

    Anthocyanins: detailed mechanisms of action (reviewed 4 October 2026) · lines 54–54

    Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Preparation identity/scope; not isolated class causation. · source_derived_draft · unverified_draft

    **Blueberry FMD timing tracks a changing exposure.** Acute crossover experiments in healthy men found FMD increases at 1–2 and six hours, associated with circulating phenolics and lower neutrophil NADPH-oxidase activity. A plateau occurred above roughly 766 mg of total blueberry polyphenols in that protocol. This was neither 766 mg purified anthocyanins nor a universal optimum. Neutrophil measurements cannot be relabeled direct endothelial NOX inhibition. [Rodriguez-Mateos et al., 2013](https://pubmed.ncbi.nlm.nih.gov/24004888/).
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.