Component
Human neutrophil NADPH oxidase activity
Human neutrophil NADPH oxidase activity. Interpret through the linked experimental species, preparation, compartment and exposure; no universal causal effect is implied.
1 recorded relationships. Experimental role, claim status and evidence remain attached to each record.
How nutrients influence it
Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.
Other things that act on it
Enzymes, hormones, genes, and other components with a recorded effect. These are not nutrients, so they do not count toward the arrows above. Each finding names the chapter that recorded it.
How nutrients reach it in more than one step
Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.
Tracing routes…
What it does
Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.
What acts on it
Acute blueberry polyphenol intake was associated with lower neutrophil NADPH oxidase activity at times of improved FMD.
Experimental context and source evidence
- evidence_access
- Primary indexed abstract reviewed; full methods, figures, exact doses or endpoint-specific species assignments may remain unextracted.
- experimental_contrast
- {"intervention": "Blueberry polyphenol drink", "comparator": "Matched control drink", "endpoint": "Acute blueberry polyphenol intake was associated with lower neutrophil NADPH oxidase activity at times of improved FMD.", "effect_direction": "decrease", "combination": "single", "conditions": []} Explicit extracted experimental comparison; source-derived draft.
- experimental_model
- Healthy-men crossover studies; 1-2 and 6-hour sampling; measurements in neutrophils.
- interpretation_status
- Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.
- limitations
- Neutrophil assay and temporal association; not direct endothelial NOX binding or proof of mediation.
- plain_language
- Acute blueberry polyphenol intake was associated with lower neutrophil NADPH oxidase activity at times of improved FMD.
- primary_references
- Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. | 2013 | DOI 10.3945/ajcn.113.066639 | PMID 24004888 | https://pubmed.ncbi.nlm.nih.gov/24004888/ | https://doi.org/10.3945/ajcn.113.066639
- source_locator
- Reviewed reference lines 54-54; exact primary location described in quoted passage where extracted.
Anthocyanins: detailed mechanisms of action (reviewed 4 October 2026) · lines 54–54
Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication. · supports · Healthy-men crossover studies; 1-2 and 6-hour sampling; measurements in neutrophils. · source_derived_draft · unverified_draft
**Blueberry FMD timing tracks a changing exposure.** Acute crossover experiments in healthy men found FMD increases at 1–2 and six hours, associated with circulating phenolics and lower neutrophil NADPH-oxidase activity. A plateau occurred above roughly 766 mg of total blueberry polyphenols in that protocol. This was neither 766 mg purified anthocyanins nor a universal optimum. Neutrophil measurements cannot be relabeled direct endothelial NOX inhibition. [Rodriguez-Mateos et al., 2013](https://pubmed.ncbi.nlm.nih.gov/24004888/).
Complete structured claim and evidence
The events it takes part in
A mechanism often involves more than two components. These are the full events, with every participant and its role.
Situations it appears in
Low-supply and faulty-machinery situations recorded in the chapters where this component plays a part.
In the sources
Preserved passages that mention this component, quoted exactly. Open one to read it in context.
Open hypotheses
Proposed ideas that involve this component. They are labeled as hypotheses and do not change any recorded statement.
This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.