{"id":"27ed8616-6ecb-5e93-acc4-6e7a42da9daf","stable_key":"35ec55a7-323c-5c28-979e-3bdafe9d5769:preparation-scope-blueberry-polyphenol-drink","predicate":"present_in_specified_preparation","statement":"The specified preparation contains anthocyanins; its experimental effects remain attached to the actual preparation. ","claim_class":"identity","status":"source_derived_draft","evidence_grade":"ungraded","direction":"neutral","is_public":true,"mechanism_event_id":"09f08f5e-f8e7-53db-872c-aac6f9a5d3c9","mechanism_event_label":"The specified preparation contains anthocyanins; its experimental effects remain attached to the actual preparation. ","subject":{"id":"a1b1c9c3-cafe-5dd6-a590-f56222d3a4cc","slug":"anthocyanins","display_name":"Anthocyanins","entity_type_key":"chemical_species"},"object":{"id":"8f12b9ac-46fe-5bef-bd17-cca7f22f1668","slug":"blueberry-polyphenol-drink","display_name":"Blueberry polyphenol drink in acute vascular studies","entity_type_key":"botanical"},"evidence_count":1,"mechanism_event":{"id":"09f08f5e-f8e7-53db-872c-aac6f9a5d3c9","stable_key":"35ec55a7-323c-5c28-979e-3bdafe9d5769:preparation-scope-blueberry-polyphenol-drink-event","event_type":"preparation_composition","label":"The specified preparation contains anthocyanins; its experimental effects remain attached to the actual preparation. ","description":"**Blueberry FMD timing tracks a changing exposure.** Acute crossover experiments in healthy men found FMD increases at 1–2 and six hours, associated with circulating phenolics and lower neutrophil NADPH-oxidase activity. A plateau occurred above roughly 766 mg of total blueberry polyphenols in that protocol. This was neither 766 mg purified anthocyanins nor a universal optimum. Neutrophil measurements cannot be relabeled direct endothelial NOX inhibition. [Rodriguez-Mateos et al., 2013](https://pubmed.ncbi.nlm.nih.gov/24004888/).","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a1b1c9c3-cafe-5dd6-a590-f56222d3a4cc","slug":"anthocyanins","display_name":"Anthocyanins","entity_type_key":"chemical_species"},"role":"tested factor","stoichiometry":null,"state_label":"as reported","sequence_order":0,"notes":""},{"entity":{"id":"8f12b9ac-46fe-5bef-bd17-cca7f22f1668","slug":"blueberry-polyphenol-drink","display_name":"Blueberry polyphenol drink in acute vascular studies","entity_type_key":"botanical"},"role":"measured outcome","stoichiometry":null,"state_label":"not_reported","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary indexed abstract reviewed; full methods, figures, exact doses or endpoint-specific species assignments may remain unextracted.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Preparation identity/scope; not isolated class causation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"interpretation_status","value_text":"Source-derived extraction of a fact-checked reference; access is explicit, not independent raw-data verification.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A food or extract contains other constituents. Membership is a navigation link and does not transfer its findings to isolated anthocyanins.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The specified preparation contains anthocyanins; its experimental effects remain attached to the actual preparation. ","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity. | 2013 | DOI 10.3945/ajcn.113.066639 | PMID 24004888 | https://pubmed.ncbi.nlm.nih.gov/24004888/ | https://doi.org/10.3945/ajcn.113.066639","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"source_locator","value_text":"Reviewed reference lines 54-54; exact primary location described in quoted passage where extracted.","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"c9de3b6f-a488-5839-bace-a91b7c9778b7","evidence_kind":"source_excerpt","locator":"Lines 54-54","start_line":54,"end_line":54,"excerpt":"**Blueberry FMD timing tracks a changing exposure.** Acute crossover experiments in healthy men found FMD increases at 1–2 and six hours, associated with circulating phenolics and lower neutrophil NADPH-oxidase activity. A plateau occurred above roughly 766 mg of total blueberry polyphenols in that protocol. This was neither 766 mg purified anthocyanins nor a universal optimum. Neutrophil measurements cannot be relabeled direct endothelial NOX inhibition. [Rodriguez-Mateos et al., 2013](https://pubmed.ncbi.nlm.nih.gov/24004888/).","model_system":"Preparation identity/scope; not isolated class causation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Exact excerpt of the retained AI-assisted reviewed reference; primary sources are cited in primary_references and access scope is retained. Not a verbatim quotation from a primary paper.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"b08e7f7d-4d34-56d7-a185-2124f8d72b3c","stable_key":"import-35ec55a7-323c-5c28-979e-3bdafe9d5769","title":"Anthocyanins: detailed mechanisms of action (reviewed 4 October 2026)","document_type":"imported_text","citation_label":"Original AI-assisted review of primary studies and, where relevant, official regulatory records. Access level is retained per claim. Corrections, null results and unresolved questions remain explicit. Not publisher full text or independent replication.","file_path":"","sha256":"7cff1a47fbd9c625412b84162b1c823004b4162b7c009f9a11d5807fb8e04ef9","revision_id":"1bd4fa42-bfeb-5148-8250-fc363d8c1de0","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}