{"id":"1b646d81-2bee-5ec1-b644-3d4c6795b6db","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-peak-fmd-null","predicate":"did_not_significantly_change","statement":"Neither 450 nor 900 mg significantly changed peak FMD versus control.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"61c1e2d4-891b-541e-a3ba-4b2a3a3f9d43","mechanism_event_label":"The main peak response was null.","subject":{"id":"705c7f84-5840-55e1-be69-383cc8793a06","slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"},"object":{"id":"a557fb69-ee27-5be9-8318-227c570267ff","slug":"flow-mediated-dilation","display_name":"Brachial artery flow-mediated dilation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"61c1e2d4-891b-541e-a3ba-4b2a3a3f9d43","stable_key":"00c24cfe-6189-5244-b81f-5d693e4e177d:chlorogenic_acid-peak-fmd-null-event","event_type":"observed_intervention","label":"The main peak response was null.","description":"Neither 450 nor 900 mg significantly changed peak FMD versus control.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"705c7f84-5840-55e1-be69-383cc8793a06","slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a557fb69-ee27-5be9-8318-227c570267ff","slug":"flow-mediated-dilation","display_name":"Brachial artery flow-mediated dilation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_span","value_text":"{\"source_cache\": \"artifacts/chlorogenic_acid-research/27109860.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e8a19a33418ce3a635bd5d8d0d2189175a8e555131a1059441eac4d03dfc91c8\", \"start_char\": 0, \"end_char\": 1585, \"text_sha256\": \"e8a19a33418ce3a635bd5d8d0d2189175a8e555131a1059441eac4d03dfc91c8\"}","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Randomized-order acute crossover in 16 adults","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"exposure","value_text":"0, 450 or 900 mg purified 5-CGA; 200 mg epicatechin comparator; one-week spacing","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Peak and continuous-mean FMD are different endpoints. Secondary positive findings must not replace the null peak response; no long-term vascular outcome was tested.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"chlorogenic-acid","display_name":"Chlorogenic acid / 5-O-caffeoylquinic acid","entity_type_key":"small_molecule"}},{"dimension":"organism","value_text":"Human","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"The main peak response was null.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[chlorogenic_acid-p27109860] Acute effects of chlorogenic acids on endothelial function and blood pressure in healthy men and women. (2016). https://pubmed.ncbi.nlm.nih.gov/27109860/ DOI: 10.1039/c6fo00248j","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brachial flow-mediated dilation and blood pressure","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"7ef78a7d-2585-5fe1-b9db-446e14021402","evidence_kind":"source_excerpt","locator":"Lines 958-969","start_line":958,"end_line":969,"excerpt":"### chlorogenic_acid-peak-fmd-null\nNeither 450 nor 900 mg significantly changed peak FMD versus control.\nCondition category: normal\nnutrient_topic: Chlorogenic acid research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: The main peak response was null.\norganism: Human\ntissue_or_cell_type: Brachial flow-mediated dilation and blood pressure\nexperimental_model: Randomized-order acute crossover in 16 adults\nlimitations: Peak and continuous-mean FMD are different endpoints. Secondary positive findings must not replace the null peak response; no long-term vascular outcome was tested.\nexposure: 0, 450 or 900 mg purified 5-CGA; 200 mg epicatechin comparator; one-week spacing\nevidence_span: {\"source_cache\": \"artifacts/chlorogenic_acid-research/27109860.abstract.txt\", \"locator\": \"Primary indexed abstract; zero-based, end-exclusive Unicode character offsets\", \"file_sha256\": \"e8a19a33418ce3a635bd5d8d0d2189175a8e555131a1059441eac4d03dfc91c8\", \"start_char\": 0, \"end_char\": 1585, \"text_sha256\": \"e8a19a33418ce3a635bd5d8d0d2189175a8e555131a1059441eac4d03dfc91c8\"}\n[chlorogenic_acid-p27109860] Acute effects of chlorogenic acids on endothelial function and blood pressure in healthy men and women. (2016). https://pubmed.ncbi.nlm.nih.gov/27109860/ DOI: 10.1039/c6fo00248j","model_system":"Randomized-order acute crossover in 16 adults","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [chlorogenic_acid-p27109860] Acute effects of chlorogenic acids on endothelial function and blood pressure in healthy men and women. (2016). https://pubmed.ncbi.nlm.nih.gov/27109860/ DOI: 10.1039/c6fo00248j","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"98a7cb8d-1d80-5cfe-9690-4068d21878e3","stable_key":"import-00c24cfe-6189-5244-b81f-5d693e4e177d","title":"Chlorogenic acid: metabolism, signaling and nutrient connections (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"dabd56b55fb10d82913b222343d9592d3baf61ef3cc81cf47f3e3e7537eb7992","revision_id":"340aee2f-52a6-56aa-99c1-0a24c534752a","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}