{"id":"ab69aab7-c437-529f-a000-79895840a5a6","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-controlled-feeding-fmd","predicate":"supplementation_increases","statement":"The endothelial substudy found a 1.16-percentage-point increase in flow-mediated dilation with potassium.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"positive","is_public":true,"mechanism_event_id":"fdfb31c8-a734-55e7-a3c1-d08db0e21b97","mechanism_event_label":"A vessel-response measurement improved in this subgroup.","subject":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"object":{"id":"a557fb69-ee27-5be9-8318-227c570267ff","slug":"flow-mediated-dilation","display_name":"Brachial artery flow-mediated dilation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"fdfb31c8-a734-55e7-a3c1-d08db0e21b97","stable_key":"5102beb6-9f61-500e-af10-9ac63649e0b7:k-controlled-feeding-fmd-event","event_type":"observed_intervention","label":"A vessel-response measurement improved in this subgroup.","description":"The endothelial substudy found a 1.16-percentage-point increase in flow-mediated dilation with potassium.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"87435e1d-e1cd-57da-984b-203b2f5f29a4","slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a557fb69-ee27-5be9-8318-227c570267ff","slug":"flow-mediated-dilation","display_name":"Brachial artery flow-mediated dilation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"experimental_model","value_text":"FMD subgroup, 22-24 usable measurements per comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Same parent trial; no direct demonstration of nitric oxide or a particular channel as mediator.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Potassium research collection; topical membership is not evidence of a direct dietary effect.","comparator":null,"unit":null,"notes":"","entity":{"slug":"potassium","display_name":"Potassium","entity_type_key":"nutrient_element"}},{"dimension":"organism","value_text":"Homo sapiens","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"plain_language","value_text":"A vessel-response measurement improved in this subgroup.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"[k-gijsbers2015-fmd] Effects of sodium and potassium supplementation on endothelial function: a fully controlled dietary intervention study (2015). https://pubmed.ncbi.nlm.nih.gov/26343780/ DOI: 10.1017/s0007114515002986","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"tissue_or_cell_type","value_text":"Brachial artery","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"141c7135-7164-5868-bd22-b3b9136c7f48","evidence_kind":"source_excerpt","locator":"Lines 1557-1566","start_line":1557,"end_line":1566,"excerpt":"### k-controlled-feeding-fmd\nThe endothelial substudy found a 1.16-percentage-point increase in flow-mediated dilation with potassium.\nCondition category: normal\nnutrient_topic: Potassium research collection; topical membership is not evidence of a direct dietary effect.\nplain_language: A vessel-response measurement improved in this subgroup.\norganism: Homo sapiens\ntissue_or_cell_type: Brachial artery\nexperimental_model: FMD subgroup, 22-24 usable measurements per comparison.\nlimitations: Same parent trial; no direct demonstration of nitric oxide or a particular channel as mediator.\n[k-gijsbers2015-fmd] Effects of sodium and potassium supplementation on endothelial function: a fully controlled dietary intervention study (2015). https://pubmed.ncbi.nlm.nih.gov/26343780/ DOI: 10.1017/s0007114515002986","model_system":"FMD subgroup, 22-24 usable measurements per comparison.","directness":"author_interpretation","verification_status":"source_derived_draft","notes":"Exact curation-document quotation, not publisher quotation. Study references: [k-gijsbers2015-fmd] Effects of sodium and potassium supplementation on endothelial function: a fully controlled dietary intervention study (2015). https://pubmed.ncbi.nlm.nih.gov/26343780/ DOI: 10.1017/s0007114515002986","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"241226ee-6b7d-5cc7-9781-e6beb8ee1982","stable_key":"import-5102beb6-9f61-500e-af10-9ac63649e0b7","title":"Potassium: cross-nutrient mechanisms and deficiency (2026-09-17)","document_type":"imported_text","citation_label":"AI-assisted literature curation; primary study URLs and scope retained in the document and extraction. Not publisher full text.","file_path":"","sha256":"a8f89f8d84b48c0f93048dfc45f7f57a67dd9a7249968a096a14aeb03d8b7a52","revision_id":"de4ec6f4-58a1-537b-8169-97b783898df1","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}