Component

cis-9,trans-11 conjugated linoleic acid / rumenic acid

Context-specific entity; species, compartment and exposure are stated on each claim.

14 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. c9,t11 increased arachidonate incorporation into phosphatidylcholine despite lower overall incorporation into membrane phospholipids.

    cis-9,trans-11 conjugated linoleic acid / rumenic acid → Human endothelial arachidonate incorporation into phosphatidylcholine source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human endothelial radiotracer experiment.
    limitations
    Does not show that extra choline reproduces the effect.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    A fatty acid was redistributed between membrane lipid pools.
    primary_references
    The effect of conjugated linoleic acid on arachidonic acid metabolism and eicosanoid production in human saphenous vein endothelial cells. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11880240/ · DOI 10.1016/s1388-1981(01)00198-6

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 302–308

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human endothelial radiotracer experiment. · source_derived_draft · unverified_draft

    ## cla-aa-pc A fatty acid was redistributed between membrane lipid pools. c9,t11 increased arachidonate incorporation into phosphatidylcholine despite lower overall incorporation into membrane phospholipids. Model: Human endothelial radiotracer experiment. Limitations: Does not show that extra choline reproduces the effect. Evidence access: Primary abstract The effect of conjugated linoleic acid on arachidonic acid metabolism and eicosanoid production in human saphenous vein endothelial cells. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11880240/ · DOI 10.1016/s1388-1981(01)00198-6
    Complete structured claim and evidence

  2. At 100 micromolar, c9,t11 inhibited endothelial eicosanoid production, whereas t10,c12 stimulated it.

    cis-9,trans-11 conjugated linoleic acid / rumenic acid → Human endothelial prostaglandin output source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human saphenous-vein endothelial cells with calcium-ionophore stimulation.
    limitations
    Lower-concentration results differed; no universal anti-inflammatory label.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    Isomer and concentration changed the direction of the response.
    primary_references
    The effect of conjugated linoleic acid on arachidonic acid metabolism and eicosanoid production in human saphenous vein endothelial cells. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11880240/ · DOI 10.1016/s1388-1981(01)00198-6

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 294–300

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human saphenous-vein endothelial cells with calcium-ionophore stimulation. · source_derived_draft · unverified_draft

    ## cla-endothelium-c9 Isomer and concentration changed the direction of the response. At 100 micromolar, c9,t11 inhibited endothelial eicosanoid production, whereas t10,c12 stimulated it. Model: Human saphenous-vein endothelial cells with calcium-ionophore stimulation. Limitations: Lower-concentration results differed; no universal anti-inflammatory label. Evidence access: Primary abstract The effect of conjugated linoleic acid on arachidonic acid metabolism and eicosanoid production in human saphenous vein endothelial cells. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11880240/ · DOI 10.1016/s1388-1981(01)00198-6
    Complete structured claim and evidence

  3. Three grams/day c9,t11 CLA for three months reduced insulin sensitivity 15% versus placebo, without a body-composition difference.

    cis-9,trans-11 conjugated linoleic acid / rumenic acid → Human clamp-measured insulin sensitivity in CLA trials source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Twenty-five abdominally obese men; randomized placebo-controlled clamp study.
    limitations
    Does not establish effects from ordinary dairy intake or in other populations.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    The food-predominant isomer was not uniformly favorable at supplemental exposure.
    primary_references
    Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15277146/ · DOI 10.1093/ajcn/80.2.279

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 430–436

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Twenty-five abdominally obese men; randomized placebo-controlled clamp study. · source_derived_draft · unverified_draft

    ## cla-human-c9-insulin The food-predominant isomer was not uniformly favorable at supplemental exposure. Three grams/day c9,t11 CLA for three months reduced insulin sensitivity 15% versus placebo, without a body-composition difference. Model: Twenty-five abdominally obese men; randomized placebo-controlled clamp study. Limitations: Does not establish effects from ordinary dairy intake or in other populations. Evidence access: Primary abstract Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15277146/ · DOI 10.1093/ajcn/80.2.279
    Complete structured claim and evidence

  4. Urinary 8-iso-PGF2alpha increased 50% versus placebo with c9,t11 supplementation.

    cis-9,trans-11 conjugated linoleic acid / rumenic acid → Human urinary isoprostane during CLA supplementation source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Same three-month trial.
    limitations
    Other experiments show CLA can alter marker catabolism; concentration alone does not isolate formation rate.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    A measured lipid-oxidation marker changed.
    primary_references
    Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15277146/ · DOI 10.1093/ajcn/80.2.279

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 438–444

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Same three-month trial. · source_derived_draft · unverified_draft

    ## cla-human-c9-marker A measured lipid-oxidation marker changed. Urinary 8-iso-PGF2alpha increased 50% versus placebo with c9,t11 supplementation. Model: Same three-month trial. Limitations: Other experiments show CLA can alter marker catabolism; concentration alone does not isolate formation rate. Evidence access: Primary abstract Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15277146/ · DOI 10.1093/ajcn/80.2.279
    Complete structured claim and evidence

  5. Enriched dairy increased c9,t11 CLA in plasma phosphatidylcholine, triglycerides, cholesteryl esters and peripheral blood mononuclear cells.

    cis-9,trans-11 conjugated linoleic acid / rumenic acid → Human CLA incorporation into plasma and leukocyte lipids source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Double-blind crossover in healthy men; enriched products supplied both CLA and vaccenic acid for six weeks.
    limitations
    Cannot separate direct CLA intake from precursor conversion or infer health benefit.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    CLA reached several lipid compartments.
    primary_references
    Incorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18 : 1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acids. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16115358/ · DOI 10.1079/bjn20051506

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 38–44

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Double-blind crossover in healthy men; enriched products supplied both CLA and vaccenic acid for six weeks. · source_derived_draft · unverified_draft

    ## cla-incorporation CLA reached several lipid compartments. Enriched dairy increased c9,t11 CLA in plasma phosphatidylcholine, triglycerides, cholesteryl esters and peripheral blood mononuclear cells. Model: Double-blind crossover in healthy men; enriched products supplied both CLA and vaccenic acid for six weeks. Limitations: Cannot separate direct CLA intake from precursor conversion or infer health benefit. Evidence access: Primary abstract Incorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18 : 1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acids. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16115358/ · DOI 10.1079/bjn20051506
    Complete structured claim and evidence

  6. The isomer inhibited arachidonic-acid- and collagen-induced platelet aggregation in the 5–7 micromolar I50 range.

    cis-9,trans-11 conjugated linoleic acid / rumenic acid → Human platelet aggregation, agonist specified source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human platelet preparation.
    limitations
    Reversible, timing-dependent effects; no clinical antithrombotic benefit or drug interaction quantified.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    Platelet activation changed in a laboratory assay.
    primary_references
    Antiplatelet effects of conjugated linoleic acid isomers. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10320806/ · DOI 10.1016/s1388-1981(99)00055-4

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 270–276

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human platelet preparation. · source_derived_draft · unverified_draft

    ## cla-platelets-c9 Platelet activation changed in a laboratory assay. The isomer inhibited arachidonic-acid- and collagen-induced platelet aggregation in the 5–7 micromolar I50 range. Model: Human platelet preparation. Limitations: Reversible, timing-dependent effects; no clinical antithrombotic benefit or drug interaction quantified. Evidence access: Primary abstract Antiplatelet effects of conjugated linoleic acid isomers. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10320806/ · DOI 10.1016/s1388-1981(99)00055-4
    Complete structured claim and evidence

  7. Adding c9,t11 CLA increased PPAR-gamma and several target-gene transcripts relative to vehicle.

    cis-9,trans-11 conjugated linoleic acid / rumenic acid → Human PPAR gamma / PPARG source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Primary cultures of differentiating human preadipocytes.
    limitations
    Not proof of improved insulin sensitivity in humans.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    The other isomer gave a different transcriptional response.
    primary_references
    Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12730300/ · DOI 10.1194/jlr.M300001-JLR200

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 94–100

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Primary cultures of differentiating human preadipocytes. · source_derived_draft · unverified_draft

    ## cla-pparg-expression-c9 The other isomer gave a different transcriptional response. Adding c9,t11 CLA increased PPAR-gamma and several target-gene transcripts relative to vehicle. Model: Primary cultures of differentiating human preadipocytes. Limitations: Not proof of improved insulin sensitivity in humans. Evidence access: Primary abstract Isomer-specific regulation of metabolism and PPARgamma signaling by CLA in human preadipocytes. · 2003 · https://pubmed.ncbi.nlm.nih.gov/12730300/ · DOI 10.1194/jlr.M300001-JLR200
    Complete structured claim and evidence

  8. Feeding the enriched isomer preparation increased hepatic retinyl ester accumulation.

    cis-9,trans-11 conjugated linoleic acid / rumenic acid → Mouse hepatic retinyl ester storage source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Mouse dietary isomer comparison.
    limitations
    Accumulation does not establish improved vitamin A function.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    CLA altered a vitamin A storage compartment.
    primary_references
    Hepatic retinol secretion and storage are altered by dietary CLA: common and distinct actions of CLA c9,t11 and t10,c12 isomers. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19454764/ · DOI 10.1194/jlr.M900054-JLR200

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 238–244

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse dietary isomer comparison. · source_derived_draft · unverified_draft

    ## cla-retinyl-c9 CLA altered a vitamin A storage compartment. Feeding the enriched isomer preparation increased hepatic retinyl ester accumulation. Model: Mouse dietary isomer comparison. Limitations: Accumulation does not establish improved vitamin A function. Evidence access: Primary abstract Hepatic retinol secretion and storage are altered by dietary CLA: common and distinct actions of CLA c9,t11 and t10,c12 isomers. · 2009 · https://pubmed.ncbi.nlm.nih.gov/19454764/ · DOI 10.1194/jlr.M900054-JLR200
    Complete structured claim and evidence

  9. At 45 micromolar, the isomer reduced SCD activity in MDA-MB-231 and MCF-7 cells; protein fell only in MDA-MB-231, while mRNA was not repressed.

    cis-9,trans-11 conjugated linoleic acid / rumenic acid → Human cell SCD activity source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human breast-cancer cell lines.
    limitations
    Cell-line biochemistry does not establish anticancer benefit or ordinary dietary exposure.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    The same enzyme changed through different regulatory levels.
    primary_references
    Inhibition of stearoyl-CoA desaturase activity by the cis-9,trans-11 isomer and the trans-10,cis-12 isomer of conjugated linoleic acid in MDA-MB-231 and MCF-7 human breast cancer cells. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12061775/ · DOI 10.1016/S0006-291X(02)00554-5

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 54–60

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human breast-cancer cell lines. · source_derived_draft · unverified_draft

    ## cla-scd-c9 The same enzyme changed through different regulatory levels. At 45 micromolar, the isomer reduced SCD activity in MDA-MB-231 and MCF-7 cells; protein fell only in MDA-MB-231, while mRNA was not repressed. Model: Human breast-cancer cell lines. Limitations: Cell-line biochemistry does not establish anticancer benefit or ordinary dietary exposure. Evidence access: Primary abstract Inhibition of stearoyl-CoA desaturase activity by the cis-9,trans-11 isomer and the trans-10,cis-12 isomer of conjugated linoleic acid in MDA-MB-231 and MCF-7 human breast cancer cells. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12061775/ · DOI 10.1016/S0006-291X(02)00554-5
    Complete structured claim and evidence

What acts on it

  1. Feeding increasing vaccenic-acid intakes gave an estimated mean conversion to rumenic acid of 19%, with substantial individual variation.

    trans-11 vaccenic acid → cis-9,trans-11 conjugated linoleic acid / rumenic acid source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Thirty healthy adults; 1.5, 3 or 4.5 g/day vaccenic acid for nine days.
    limitations
    Protocol-specific estimate; not an instruction to consume these amounts.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    Food-derived precursor supply contributes to measured CLA.
    primary_references
    Bioconversion of vaccenic acid to conjugated linoleic acid in humans. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12197992/ · DOI 10.1093/ajcn/76.3.504

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 30–36

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Thirty healthy adults; 1.5, 3 or 4.5 g/day vaccenic acid for nine days. · source_derived_draft · unverified_draft

    ## cla-conversion-rate Food-derived precursor supply contributes to measured CLA. Feeding increasing vaccenic-acid intakes gave an estimated mean conversion to rumenic acid of 19%, with substantial individual variation. Model: Thirty healthy adults; 1.5, 3 or 4.5 g/day vaccenic acid for nine days. Limitations: Protocol-specific estimate; not an instruction to consume these amounts. Evidence access: Primary abstract Bioconversion of vaccenic acid to conjugated linoleic acid in humans. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12197992/ · DOI 10.1093/ajcn/76.3.504
    Complete structured claim and evidence

  2. Deuterated trans-vaccenic acid administered as triglyceride produced labeled cis-9,trans-11 CLA in human serum lipids.

    trans-11 vaccenic acid → cis-9,trans-11 conjugated linoleic acid / rumenic acid source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Reanalysis of four historical single-person tracer experiments.
    limitations
    Small tracer evidence; enrichment is not a universal dietary conversion fraction.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    The body can make one CLA isomer from a distinct dietary precursor.
    primary_references
    Biosynthesis of conjugated linoleic acid in humans. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10757542/ · DOI 10.1007/BF02664761

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 22–28

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Reanalysis of four historical single-person tracer experiments. · source_derived_draft · unverified_draft

    ## cla-vaccenic-tracer The body can make one CLA isomer from a distinct dietary precursor. Deuterated trans-vaccenic acid administered as triglyceride produced labeled cis-9,trans-11 CLA in human serum lipids. Model: Reanalysis of four historical single-person tracer experiments. Limitations: Small tracer evidence; enrichment is not a universal dietary conversion fraction. Evidence access: Primary abstract Biosynthesis of conjugated linoleic acid in humans. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10757542/ · DOI 10.1007/BF02664761
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Feeding 0.4% t10,c12 CLA for four weeks produced fatty liver, hyperinsulinemia and lipoatrophy; c9,t11 and linoleic-acid diets did not show the same effects.

    trans-10,cis-12 conjugated linoleic acid → Mouse hepatic lipid accumulation source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Mouse dietary comparison.
    limitations
    Not a human risk estimate or proof that insulin caused the liver phenotype.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    Loss of adipose fat coexisted with liver fat accumulation.
    primary_references
    Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12235171/ · DOI 10.1194/jlr.m20008-jlr200

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 214–220

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Mouse dietary comparison. · source_derived_draft · unverified_draft

    ## cla-mouse-liver Loss of adipose fat coexisted with liver fat accumulation. Feeding 0.4% t10,c12 CLA for four weeks produced fatty liver, hyperinsulinemia and lipoatrophy; c9,t11 and linoleic-acid diets did not show the same effects. Model: Mouse dietary comparison. Limitations: Not a human risk estimate or proof that insulin caused the liver phenotype. Evidence access: Primary abstract Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12235171/ · DOI 10.1194/jlr.m20008-jlr200
    Complete structured claim and evidence

  2. Adding t10,c12, but not c9,t11 CLA, suppressed ligand-stimulated PPAR-gamma reporter activation.

    trans-10,cis-12 conjugated linoleic acid → Human adipocyte PPAR-gamma reporter activity source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Primary human adipocyte culture and reporter experiments.
    limitations
    The 2003 transient-transfection study reported antagonism with both isomers; assay context remains relevant.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    An isomer could interfere with activation of the regulator.
    primary_references
    Trans-10, cis-12 conjugated linoleic acid antagonizes ligand-dependent PPARgamma activity in primary cultures of human adipocytes. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18287349/ · DOI 10.1093/jn/138.3.455

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 102–108

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Primary human adipocyte culture and reporter experiments. · source_derived_draft · unverified_draft

    ## cla-pparg-antagonism An isomer could interfere with activation of the regulator. Adding t10,c12, but not c9,t11 CLA, suppressed ligand-stimulated PPAR-gamma reporter activation. Model: Primary human adipocyte culture and reporter experiments. Limitations: The 2003 transient-transfection study reported antagonism with both isomers; assay context remains relevant. Evidence access: Primary abstract Trans-10, cis-12 conjugated linoleic acid antagonizes ligand-dependent PPARgamma activity in primary cultures of human adipocytes. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18287349/ · DOI 10.1093/jn/138.3.455
    Complete structured claim and evidence

  3. The mixture and individual isomers reduced arachidonate-derived TXB2 formation, while platelet 12-HETE formation was not inhibited.

    Study-specific mixed-isomer CLA preparations → Human platelet thromboxane B2 formation source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human platelet radiotracer assay.
    limitations
    TXB2 is the measured readout of TXA2 formation.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    Two branches from the same fatty acid responded differently.
    primary_references
    Antiplatelet effects of conjugated linoleic acid isomers. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10320806/ · DOI 10.1016/s1388-1981(99)00055-4

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 286–292

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Human platelet radiotracer assay. · source_derived_draft · unverified_draft

    ## cla-txb2 Two branches from the same fatty acid responded differently. The mixture and individual isomers reduced arachidonate-derived TXB2 formation, while platelet 12-HETE formation was not inhibited. Model: Human platelet radiotracer assay. Limitations: TXB2 is the measured readout of TXA2 formation. Evidence access: Primary abstract Antiplatelet effects of conjugated linoleic acid isomers. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10320806/ · DOI 10.1016/s1388-1981(99)00055-4
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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