{"id":"e08c8766-bbf2-5df9-b8f0-35d1c120f87b","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-human-c9-marker","predicate":"increases","statement":"Urinary 8-iso-PGF2alpha increased 50% versus placebo with c9,t11 supplementation.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"68a6901f-188f-5a44-9c6c-97d62f4f0deb","mechanism_event_label":"A measured lipid-oxidation marker changed.","subject":{"id":"a85c068b-9c0b-5a08-bad7-66ff3ef2af19","slug":"cla-cis9-trans11","display_name":"cis-9,trans-11 conjugated linoleic acid / rumenic acid","entity_type_key":"small_molecule"},"object":{"id":"c8793bf4-0c2b-5d4d-8c8a-7a01f8b5f6e0","slug":"human-cla-urinary-isoprostane","display_name":"Human urinary isoprostane during CLA supplementation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"68a6901f-188f-5a44-9c6c-97d62f4f0deb","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-human-c9-marker-event","event_type":"observed_relationship","label":"A measured lipid-oxidation marker changed.","description":"Urinary 8-iso-PGF2alpha increased 50% versus placebo with c9,t11 supplementation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a85c068b-9c0b-5a08-bad7-66ff3ef2af19","slug":"cla-cis9-trans11","display_name":"cis-9,trans-11 conjugated linoleic acid / rumenic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"c8793bf4-0c2b-5d4d-8c8a-7a01f8b5f6e0","slug":"human-cla-urinary-isoprostane","display_name":"Human urinary isoprostane during CLA supplementation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"03e13409-d8c4-540e-a186-eeed0d71b5c1","slug":"8-iso-pgf2alpha","display_name":"8-iso-Prostaglandin F2alpha","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Same three-month trial.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Other experiments show CLA can alter marker catabolism; concentration alone does not isolate formation rate.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A measured lipid-oxidation marker changed.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15277146/ · DOI 10.1093/ajcn/80.2.279","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2c1b24e2-f6fb-5e97-9392-3af5255ca4a9","evidence_kind":"source_excerpt","locator":"Lines 438-444","start_line":438,"end_line":444,"excerpt":"## cla-human-c9-marker\nA measured lipid-oxidation marker changed.\nUrinary 8-iso-PGF2alpha increased 50% versus placebo with c9,t11 supplementation.\nModel: Same three-month trial.\nLimitations: Other experiments show CLA can alter marker catabolism; concentration alone does not isolate formation rate.\nEvidence access: Primary abstract\nEffects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15277146/ · DOI 10.1093/ajcn/80.2.279","model_system":"Same three-month trial.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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