{"id":"6f5a3583-5e77-5b2b-ab0a-be9e6ece4306","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-vaccenic-tracer","predicate":"converted_to","statement":"Deuterated trans-vaccenic acid administered as triglyceride produced labeled cis-9,trans-11 CLA in human serum lipids.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ea4891a3-9e86-5dcc-9e02-cb8232795293","mechanism_event_label":"The body can make one CLA isomer from a distinct dietary precursor.","subject":{"id":"289ee924-1d77-572e-84c7-6c97ace91a83","slug":"trans-vaccenic-acid","display_name":"trans-11 vaccenic acid","entity_type_key":"small_molecule"},"object":{"id":"a85c068b-9c0b-5a08-bad7-66ff3ef2af19","slug":"cla-cis9-trans11","display_name":"cis-9,trans-11 conjugated linoleic acid / rumenic acid","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"ea4891a3-9e86-5dcc-9e02-cb8232795293","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-vaccenic-tracer-event","event_type":"observed_relationship","label":"The body can make one CLA isomer from a distinct dietary precursor.","description":"Deuterated trans-vaccenic acid administered as triglyceride produced labeled cis-9,trans-11 CLA in human serum lipids.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"289ee924-1d77-572e-84c7-6c97ace91a83","slug":"trans-vaccenic-acid","display_name":"trans-11 vaccenic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a85c068b-9c0b-5a08-bad7-66ff3ef2af19","slug":"cla-cis9-trans11","display_name":"cis-9,trans-11 conjugated linoleic acid / rumenic acid","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"ff05052c-a102-5f63-bc9b-66a7a632ebf3","slug":"scd","display_name":"Human stearoyl-CoA desaturase / SCD","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Reanalysis of four historical single-person tracer experiments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Small tracer evidence; enrichment is not a universal dietary conversion fraction.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"The body can make one CLA isomer from a distinct dietary precursor.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Biosynthesis of conjugated linoleic acid in humans. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10757542/ · DOI 10.1007/BF02664761","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"74e8b09d-7641-529c-9c8d-e8d44cc57bc9","evidence_kind":"source_excerpt","locator":"Lines 22-28","start_line":22,"end_line":28,"excerpt":"## cla-vaccenic-tracer\nThe body can make one CLA isomer from a distinct dietary precursor.\nDeuterated trans-vaccenic acid administered as triglyceride produced labeled cis-9,trans-11 CLA in human serum lipids.\nModel: Reanalysis of four historical single-person tracer experiments.\nLimitations: Small tracer evidence; enrichment is not a universal dietary conversion fraction.\nEvidence access: Primary abstract\nBiosynthesis of conjugated linoleic acid in humans. · 2000 · https://pubmed.ncbi.nlm.nih.gov/10757542/ · DOI 10.1007/BF02664761","model_system":"Reanalysis of four historical single-person tracer experiments.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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