Component

Human clamp-measured insulin sensitivity in CLA trials

Context-specific entity; species, compartment and exposure are stated on each claim.

3 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What acts on it

  1. Three grams/day c9,t11 CLA for three months reduced insulin sensitivity 15% versus placebo, without a body-composition difference.

    cis-9,trans-11 conjugated linoleic acid / rumenic acid → Human clamp-measured insulin sensitivity in CLA trials source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Twenty-five abdominally obese men; randomized placebo-controlled clamp study.
    limitations
    Does not establish effects from ordinary dairy intake or in other populations.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    The food-predominant isomer was not uniformly favorable at supplemental exposure.
    primary_references
    Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15277146/ · DOI 10.1093/ajcn/80.2.279

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 430–436

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Twenty-five abdominally obese men; randomized placebo-controlled clamp study. · source_derived_draft · unverified_draft

    ## cla-human-c9-insulin The food-predominant isomer was not uniformly favorable at supplemental exposure. Three grams/day c9,t11 CLA for three months reduced insulin sensitivity 15% versus placebo, without a body-composition difference. Model: Twenty-five abdominally obese men; randomized placebo-controlled clamp study. Limitations: Does not establish effects from ordinary dairy intake or in other populations. Evidence access: Primary abstract Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15277146/ · DOI 10.1093/ajcn/80.2.279
    Complete structured claim and evidence

  2. The purified t10,c12 arm increased insulin resistance by 19% and glycemia by 4% versus placebo.

    trans-10,cis-12 conjugated linoleic acid → Human clamp-measured insulin sensitivity in CLA trials source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Sixty abdominally obese men with metabolic-syndrome features; 12-week three-arm trial, 3.4 g/day assigned CLA preparation.
    limitations
    The mixed-isomer arm did not show the same glucose effect; formulation and population matter.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    The isolated isomer impaired glucose handling in this population.
    primary_references
    Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12196420/ · DOI 10.2337/diacare.25.9.1516

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 414–420

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Sixty abdominally obese men with metabolic-syndrome features; 12-week three-arm trial, 3.4 g/day assigned CLA preparation. · source_derived_draft · unverified_draft

    ## cla-human-t10-insulin The isolated isomer impaired glucose handling in this population. The purified t10,c12 arm increased insulin resistance by 19% and glycemia by 4% versus placebo. Model: Sixty abdominally obese men with metabolic-syndrome features; 12-week three-arm trial, 3.4 g/day assigned CLA preparation. Limitations: The mixed-isomer arm did not show the same glucose effect; formulation and population matter. Evidence access: Primary abstract Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12196420/ · DOI 10.2337/diacare.25.9.1516
    Complete structured claim and evidence

  3. Six months of mixed-isomer CLA produced no significant clamp-measured insulin-sensitivity difference from placebo.

    Study-specific mixed-isomer CLA preparations → Human clamp-measured insulin sensitivity in CLA trials source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Substudy of a 118-person trial; 49 entered clamp substudy and 41 completed paired clamps.
    limitations
    A nonsignificant result is not proof of equivalence or universal safety.
    nutrient_topic
    CLA collection; isomer, preparation, species, exposure and manipulation remain explicit. · Conjugated linoleic acid / CLA isomer family
    plain_language
    Another preparation and population gave a different result.
    primary_references
    The effect of 6 months supplementation with conjugated linoleic acid on insulin resistance in overweight and obese. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17031391/ · DOI 10.1038/sj.ijo.0803482

    Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19) · lines 446–452

    AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text. · supports · Substudy of a 118-person trial; 49 entered clamp substudy and 41 completed paired clamps. · source_derived_draft · unverified_draft

    ## cla-mixed-clamp Another preparation and population gave a different result. Six months of mixed-isomer CLA produced no significant clamp-measured insulin-sensitivity difference from placebo. Model: Substudy of a 118-person trial; 49 entered clamp substudy and 41 completed paired clamps. Limitations: A nonsignificant result is not proof of equivalence or universal safety. Evidence access: Primary abstract The effect of 6 months supplementation with conjugated linoleic acid on insulin resistance in overweight and obese. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17031391/ · DOI 10.1038/sj.ijo.0803482
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

    Evidence, AI assistance and curation standards