{"id":"9ca107b0-a466-5a29-b9b4-26cbd393ea05","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-mixed-clamp","predicate":"no_significant_change","statement":"Six months of mixed-isomer CLA produced no significant clamp-measured insulin-sensitivity difference from placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"4730003c-d3f4-5203-93ea-05d3f418942b","mechanism_event_label":"Another preparation and population gave a different result.","subject":{"id":"6f0cf7bd-c6e5-52d1-92f8-dd5c879e3c57","slug":"cla-mixed-isomer-preparations","display_name":"Study-specific mixed-isomer CLA preparations","entity_type_key":"chemical_species"},"object":{"id":"78978549-6ef8-5ee2-9ba5-5ccacbe56f68","slug":"human-cla-clamp-insulin-sensitivity","display_name":"Human clamp-measured insulin sensitivity in CLA trials","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"4730003c-d3f4-5203-93ea-05d3f418942b","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-mixed-clamp-event","event_type":"observed_relationship","label":"Another preparation and population gave a different result.","description":"Six months of mixed-isomer CLA produced no significant clamp-measured insulin-sensitivity difference from placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"6f0cf7bd-c6e5-52d1-92f8-dd5c879e3c57","slug":"cla-mixed-isomer-preparations","display_name":"Study-specific mixed-isomer CLA preparations","entity_type_key":"chemical_species"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"78978549-6ef8-5ee2-9ba5-5ccacbe56f68","slug":"human-cla-clamp-insulin-sensitivity","display_name":"Human clamp-measured insulin sensitivity in CLA trials","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Substudy of a 118-person trial; 49 entered clamp substudy and 41 completed paired clamps.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"A nonsignificant result is not proof of equivalence or universal safety.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Another preparation and population gave a different result.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The effect of 6 months supplementation with conjugated linoleic acid on insulin resistance in overweight and obese. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17031391/ · DOI 10.1038/sj.ijo.0803482","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"4999e40c-5710-5631-92de-b9a40c5b6cf6","evidence_kind":"source_excerpt","locator":"Lines 446-452","start_line":446,"end_line":452,"excerpt":"## cla-mixed-clamp\nAnother preparation and population gave a different result.\nSix months of mixed-isomer CLA produced no significant clamp-measured insulin-sensitivity difference from placebo.\nModel: Substudy of a 118-person trial; 49 entered clamp substudy and 41 completed paired clamps.\nLimitations: A nonsignificant result is not proof of equivalence or universal safety.\nEvidence access: Primary abstract\nThe effect of 6 months supplementation with conjugated linoleic acid on insulin resistance in overweight and obese. · 2007 · https://pubmed.ncbi.nlm.nih.gov/17031391/ · DOI 10.1038/sj.ijo.0803482","model_system":"Substudy of a 118-person trial; 49 entered clamp substudy and 41 completed paired clamps.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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