{"id":"45d99946-0b6b-5b39-a3ba-aa39dcc3aae1","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-human-t10-insulin","predicate":"worsens_trial_measure","statement":"The purified t10,c12 arm increased insulin resistance by 19% and glycemia by 4% versus placebo.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"6165afb3-1e60-510f-8cbc-fd58e59ce0fb","mechanism_event_label":"The isolated isomer impaired glucose handling in this population.","subject":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"object":{"id":"78978549-6ef8-5ee2-9ba5-5ccacbe56f68","slug":"human-cla-clamp-insulin-sensitivity","display_name":"Human clamp-measured insulin sensitivity in CLA trials","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"6165afb3-1e60-510f-8cbc-fd58e59ce0fb","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-human-t10-insulin-event","event_type":"observed_relationship","label":"The isolated isomer impaired glucose handling in this population.","description":"The purified t10,c12 arm increased insulin resistance by 19% and glycemia by 4% versus placebo.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"78978549-6ef8-5ee2-9ba5-5ccacbe56f68","slug":"human-cla-clamp-insulin-sensitivity","display_name":"Human clamp-measured insulin sensitivity in CLA trials","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Sixty abdominally obese men with metabolic-syndrome features; 12-week three-arm trial, 3.4 g/day assigned CLA preparation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The mixed-isomer arm did not show the same glucose effect; formulation and population matter.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"The isolated isomer impaired glucose handling in this population.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Treatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12196420/ · DOI 10.2337/diacare.25.9.1516","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"97421857-6927-532e-8b09-ba531c6fbb32","evidence_kind":"source_excerpt","locator":"Lines 414-420","start_line":414,"end_line":420,"excerpt":"## cla-human-t10-insulin\nThe isolated isomer impaired glucose handling in this population.\nThe purified t10,c12 arm increased insulin resistance by 19% and glycemia by 4% versus placebo.\nModel: Sixty abdominally obese men with metabolic-syndrome features; 12-week three-arm trial, 3.4 g/day assigned CLA preparation.\nLimitations: The mixed-isomer arm did not show the same glucose effect; formulation and population matter.\nEvidence access: Primary abstract\nTreatment with dietary trans10cis12 conjugated linoleic acid causes isomer-specific insulin resistance in obese men with the metabolic syndrome. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12196420/ · DOI 10.2337/diacare.25.9.1516","model_system":"Sixty abdominally obese men with metabolic-syndrome features; 12-week three-arm trial, 3.4 g/day assigned CLA preparation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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