{"id":"804b4fbf-eff6-5ed1-94c9-5efa665dbb4b","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-human-c9-insulin","predicate":"worsens_trial_measure","statement":"Three grams/day c9,t11 CLA for three months reduced insulin sensitivity 15% versus placebo, without a body-composition difference.","claim_class":"observational","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"b54727a4-4ef3-5d4b-aabe-ca931f9f6182","mechanism_event_label":"The food-predominant isomer was not uniformly favorable at supplemental exposure.","subject":{"id":"a85c068b-9c0b-5a08-bad7-66ff3ef2af19","slug":"cla-cis9-trans11","display_name":"cis-9,trans-11 conjugated linoleic acid / rumenic acid","entity_type_key":"small_molecule"},"object":{"id":"78978549-6ef8-5ee2-9ba5-5ccacbe56f68","slug":"human-cla-clamp-insulin-sensitivity","display_name":"Human clamp-measured insulin sensitivity in CLA trials","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"b54727a4-4ef3-5d4b-aabe-ca931f9f6182","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-human-c9-insulin-event","event_type":"observed_relationship","label":"The food-predominant isomer was not uniformly favorable at supplemental exposure.","description":"Three grams/day c9,t11 CLA for three months reduced insulin sensitivity 15% versus placebo, without a body-composition difference.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a85c068b-9c0b-5a08-bad7-66ff3ef2af19","slug":"cla-cis9-trans11","display_name":"cis-9,trans-11 conjugated linoleic acid / rumenic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"78978549-6ef8-5ee2-9ba5-5ccacbe56f68","slug":"human-cla-clamp-insulin-sensitivity","display_name":"Human clamp-measured insulin sensitivity in CLA trials","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Twenty-five abdominally obese men; randomized placebo-controlled clamp study.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not establish effects from ordinary dairy intake or in other populations.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"The food-predominant isomer was not uniformly favorable at supplemental exposure.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Effects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15277146/ · DOI 10.1093/ajcn/80.2.279","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"b95d6df8-79f4-54bb-bdd2-3ea6c20d449b","evidence_kind":"source_excerpt","locator":"Lines 430-436","start_line":430,"end_line":436,"excerpt":"## cla-human-c9-insulin\nThe food-predominant isomer was not uniformly favorable at supplemental exposure.\nThree grams/day c9,t11 CLA for three months reduced insulin sensitivity 15% versus placebo, without a body-composition difference.\nModel: Twenty-five abdominally obese men; randomized placebo-controlled clamp study.\nLimitations: Does not establish effects from ordinary dairy intake or in other populations.\nEvidence access: Primary abstract\nEffects of cis-9,trans-11 conjugated linoleic acid supplementation on insulin sensitivity, lipid peroxidation, and proinflammatory markers in obese men. · 2004 · https://pubmed.ncbi.nlm.nih.gov/15277146/ · DOI 10.1093/ajcn/80.2.279","model_system":"Twenty-five abdominally obese men; randomized placebo-controlled clamp study.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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