{"id":"88ea484c-7820-5c93-907c-0d9667e36ffe","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-conversion-rate","predicate":"contributes_to","statement":"Feeding increasing vaccenic-acid intakes gave an estimated mean conversion to rumenic acid of 19%, with substantial individual variation.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"e9fca2d0-ae40-525a-9df9-aeeb48faf88f","mechanism_event_label":"Food-derived precursor supply contributes to measured CLA.","subject":{"id":"289ee924-1d77-572e-84c7-6c97ace91a83","slug":"trans-vaccenic-acid","display_name":"trans-11 vaccenic acid","entity_type_key":"small_molecule"},"object":{"id":"a85c068b-9c0b-5a08-bad7-66ff3ef2af19","slug":"cla-cis9-trans11","display_name":"cis-9,trans-11 conjugated linoleic acid / rumenic acid","entity_type_key":"small_molecule"},"evidence_count":1,"mechanism_event":{"id":"e9fca2d0-ae40-525a-9df9-aeeb48faf88f","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-conversion-rate-event","event_type":"observed_relationship","label":"Food-derived precursor supply contributes to measured CLA.","description":"Feeding increasing vaccenic-acid intakes gave an estimated mean conversion to rumenic acid of 19%, with substantial individual variation.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"289ee924-1d77-572e-84c7-6c97ace91a83","slug":"trans-vaccenic-acid","display_name":"trans-11 vaccenic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"a85c068b-9c0b-5a08-bad7-66ff3ef2af19","slug":"cla-cis9-trans11","display_name":"cis-9,trans-11 conjugated linoleic acid / rumenic acid","entity_type_key":"small_molecule"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Thirty healthy adults; 1.5, 3 or 4.5 g/day vaccenic acid for nine days.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Protocol-specific estimate; not an instruction to consume these amounts.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Food-derived precursor supply contributes to measured CLA.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Bioconversion of vaccenic acid to conjugated linoleic acid in humans. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12197992/ · DOI 10.1093/ajcn/76.3.504","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"2e1448f1-c241-5f14-8f0d-7c04053b581a","evidence_kind":"source_excerpt","locator":"Lines 30-36","start_line":30,"end_line":36,"excerpt":"## cla-conversion-rate\nFood-derived precursor supply contributes to measured CLA.\nFeeding increasing vaccenic-acid intakes gave an estimated mean conversion to rumenic acid of 19%, with substantial individual variation.\nModel: Thirty healthy adults; 1.5, 3 or 4.5 g/day vaccenic acid for nine days.\nLimitations: Protocol-specific estimate; not an instruction to consume these amounts.\nEvidence access: Primary abstract\nBioconversion of vaccenic acid to conjugated linoleic acid in humans. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12197992/ · DOI 10.1093/ajcn/76.3.504","model_system":"Thirty healthy adults; 1.5, 3 or 4.5 g/day vaccenic acid for nine days.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"f9fe73a8a4008d52061c65abe6de7a9806da75f1c478c5adace9387b8ffaad9e","revision_id":"21196d9c-aaab-5fe1-8f32-2987c94289c6","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}