{"id":"d62d7537-8c7c-5fb8-b689-5f2d84a9fc0e","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-incorporation","predicate":"incorporates_into","statement":"Enriched dairy increased c9,t11 CLA in plasma phosphatidylcholine, triglycerides, cholesteryl esters and peripheral blood mononuclear cells.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"ad9d8d81-e5fa-506f-ab36-651d14f830f6","mechanism_event_label":"CLA reached several lipid compartments.","subject":{"id":"a85c068b-9c0b-5a08-bad7-66ff3ef2af19","slug":"cla-cis9-trans11","display_name":"cis-9,trans-11 conjugated linoleic acid / rumenic acid","entity_type_key":"small_molecule"},"object":{"id":"76286d2b-9ed2-5b50-9339-8e52b3866279","slug":"human-cla-plasma-cell-incorporation","display_name":"Human CLA incorporation into plasma and leukocyte lipids","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"ad9d8d81-e5fa-506f-ab36-651d14f830f6","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-incorporation-event","event_type":"observed_relationship","label":"CLA reached several lipid compartments.","description":"Enriched dairy increased c9,t11 CLA in plasma phosphatidylcholine, triglycerides, cholesteryl esters and peripheral blood mononuclear cells.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a85c068b-9c0b-5a08-bad7-66ff3ef2af19","slug":"cla-cis9-trans11","display_name":"cis-9,trans-11 conjugated linoleic acid / rumenic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"76286d2b-9ed2-5b50-9339-8e52b3866279","slug":"human-cla-plasma-cell-incorporation","display_name":"Human CLA incorporation into plasma and leukocyte lipids","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"2f77ef6d-3ecd-5a80-9ca3-3cbea403d9fc","slug":"phosphatidylcholine","display_name":"Phosphatidylcholine","entity_type_key":"lipid"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"289ee924-1d77-572e-84c7-6c97ace91a83","slug":"trans-vaccenic-acid","display_name":"trans-11 vaccenic acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Double-blind crossover in healthy men; enriched products supplied both CLA and vaccenic acid for six weeks.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Cannot separate direct CLA intake from precursor conversion or infer health benefit.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"CLA reached several lipid compartments.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Incorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18 : 1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acids. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16115358/ · DOI 10.1079/bjn20051506","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"771e4057-0c41-5df2-a759-f6efa4d26db7","evidence_kind":"source_excerpt","locator":"Lines 38-44","start_line":38,"end_line":44,"excerpt":"## cla-incorporation\nCLA reached several lipid compartments.\nEnriched dairy increased c9,t11 CLA in plasma phosphatidylcholine, triglycerides, cholesteryl esters and peripheral blood mononuclear cells.\nModel: Double-blind crossover in healthy men; enriched products supplied both CLA and vaccenic acid for six weeks.\nLimitations: Cannot separate direct CLA intake from precursor conversion or infer health benefit.\nEvidence access: Primary abstract\nIncorporation of cis-9, trans-11 conjugated linoleic acid and vaccenic acid (trans-11 18 : 1) into plasma and leucocyte lipids in healthy men consuming dairy products naturally enriched in these fatty acids. · 2005 · https://pubmed.ncbi.nlm.nih.gov/16115358/ · DOI 10.1079/bjn20051506","model_system":"Double-blind crossover in healthy men; enriched products supplied both CLA and vaccenic acid for six weeks.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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