{"id":"95bc00de-1a34-5fd0-abc8-8ea7116c56ea","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-aa-pc","predicate":"increases","statement":"c9,t11 increased arachidonate incorporation into phosphatidylcholine despite lower overall incorporation into membrane phospholipids.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"da4d5ce3-fa45-552f-9c4b-1b47f18c5d13","mechanism_event_label":"A fatty acid was redistributed between membrane lipid pools.","subject":{"id":"a85c068b-9c0b-5a08-bad7-66ff3ef2af19","slug":"cla-cis9-trans11","display_name":"cis-9,trans-11 conjugated linoleic acid / rumenic acid","entity_type_key":"small_molecule"},"object":{"id":"429a9f7c-af52-51d8-922e-32dd8fff34c8","slug":"human-endothelial-aa-phosphatidylcholine","display_name":"Human endothelial arachidonate incorporation into phosphatidylcholine","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"da4d5ce3-fa45-552f-9c4b-1b47f18c5d13","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-aa-pc-event","event_type":"observed_relationship","label":"A fatty acid was redistributed between membrane lipid pools.","description":"c9,t11 increased arachidonate incorporation into phosphatidylcholine despite lower overall incorporation into membrane phospholipids.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a85c068b-9c0b-5a08-bad7-66ff3ef2af19","slug":"cla-cis9-trans11","display_name":"cis-9,trans-11 conjugated linoleic acid / rumenic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"429a9f7c-af52-51d8-922e-32dd8fff34c8","slug":"human-endothelial-aa-phosphatidylcholine","display_name":"Human endothelial arachidonate incorporation into phosphatidylcholine","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"39f9446f-52a6-502d-b507-91137726f82c","slug":"arachidonic-acid","display_name":"AA","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"2f77ef6d-3ecd-5a80-9ca3-3cbea403d9fc","slug":"phosphatidylcholine","display_name":"Phosphatidylcholine","entity_type_key":"lipid"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human endothelial radiotracer experiment.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Does not show that extra choline reproduces the effect.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"A fatty acid was redistributed between membrane lipid pools.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"The effect of conjugated linoleic acid on arachidonic acid metabolism and eicosanoid production in human saphenous vein endothelial cells. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11880240/ · DOI 10.1016/s1388-1981(01)00198-6","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0384183d-1099-56b3-bf8d-cb42d228a35c","evidence_kind":"source_excerpt","locator":"Lines 302-308","start_line":302,"end_line":308,"excerpt":"## cla-aa-pc\nA fatty acid was redistributed between membrane lipid pools.\nc9,t11 increased arachidonate incorporation into phosphatidylcholine despite lower overall incorporation into membrane phospholipids.\nModel: Human endothelial radiotracer experiment.\nLimitations: Does not show that extra choline reproduces the effect.\nEvidence access: Primary abstract\nThe effect of conjugated linoleic acid on arachidonic acid metabolism and eicosanoid production in human saphenous vein endothelial cells. · 2002 · https://pubmed.ncbi.nlm.nih.gov/11880240/ · DOI 10.1016/s1388-1981(01)00198-6","model_system":"Human endothelial radiotracer experiment.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. 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