{"id":"88324feb-9f2d-529c-b9a2-70b83e8ef7a5","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-platelets-c9","predicate":"inhibits","statement":"The isomer inhibited arachidonic-acid- and collagen-induced platelet aggregation in the 5–7 micromolar I50 range.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"00aba14f-5d70-57a9-b42a-6a958b556b1d","mechanism_event_label":"Platelet activation changed in a laboratory assay.","subject":{"id":"a85c068b-9c0b-5a08-bad7-66ff3ef2af19","slug":"cla-cis9-trans11","display_name":"cis-9,trans-11 conjugated linoleic acid / rumenic acid","entity_type_key":"small_molecule"},"object":{"id":"7b4963e9-6cbe-5340-b19c-5141bfd3b8b5","slug":"human-platelet-aggregation","display_name":"Human platelet aggregation, agonist specified","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"00aba14f-5d70-57a9-b42a-6a958b556b1d","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-platelets-c9-event","event_type":"observed_relationship","label":"Platelet activation changed in a laboratory assay.","description":"The isomer inhibited arachidonic-acid- and collagen-induced platelet aggregation in the 5–7 micromolar I50 range.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"a85c068b-9c0b-5a08-bad7-66ff3ef2af19","slug":"cla-cis9-trans11","display_name":"cis-9,trans-11 conjugated linoleic acid / rumenic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"7b4963e9-6cbe-5340-b19c-5141bfd3b8b5","slug":"human-platelet-aggregation","display_name":"Human platelet aggregation, agonist specified","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"39f9446f-52a6-502d-b507-91137726f82c","slug":"arachidonic-acid","display_name":"AA","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Human platelet preparation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Reversible, timing-dependent effects; no clinical antithrombotic benefit or drug interaction quantified.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Platelet activation changed in a laboratory assay.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Antiplatelet effects of conjugated linoleic acid isomers. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10320806/ · DOI 10.1016/s1388-1981(99)00055-4","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"0c8c4da7-37f9-5827-b67d-d73410099d06","evidence_kind":"source_excerpt","locator":"Lines 270-276","start_line":270,"end_line":276,"excerpt":"## cla-platelets-c9\nPlatelet activation changed in a laboratory assay.\nThe isomer inhibited arachidonic-acid- and collagen-induced platelet aggregation in the 5–7 micromolar I50 range.\nModel: Human platelet preparation.\nLimitations: Reversible, timing-dependent effects; no clinical antithrombotic benefit or drug interaction quantified.\nEvidence access: Primary abstract\nAntiplatelet effects of conjugated linoleic acid isomers. · 1999 · https://pubmed.ncbi.nlm.nih.gov/10320806/ · DOI 10.1016/s1388-1981(99)00055-4","model_system":"Human platelet preparation.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"f9fe73a8a4008d52061c65abe6de7a9806da75f1c478c5adace9387b8ffaad9e","revision_id":"21196d9c-aaab-5fe1-8f32-2987c94289c6","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}