{"id":"2c6e22ad-8896-5a11-b460-9d9e32b8892e","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-mouse-liver","predicate":"increases","statement":"Feeding 0.4% t10,c12 CLA for four weeks produced fatty liver, hyperinsulinemia and lipoatrophy; c9,t11 and linoleic-acid diets did not show the same effects.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"c33416d9-ae8a-5839-afa1-a898a046aeef","mechanism_event_label":"Loss of adipose fat coexisted with liver fat accumulation.","subject":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"object":{"id":"379cafac-b5aa-5eac-83fe-ae357f9ede01","slug":"mouse-hepatic-lipid-accumulation","display_name":"Mouse hepatic lipid accumulation","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"c33416d9-ae8a-5839-afa1-a898a046aeef","stable_key":"ee4227e5-80d7-55e9-ada7-3c5a16f93ac9:cla-mouse-liver-event","event_type":"observed_relationship","label":"Loss of adipose fat coexisted with liver fat accumulation.","description":"Feeding 0.4% t10,c12 CLA for four weeks produced fatty liver, hyperinsulinemia and lipoatrophy; c9,t11 and linoleic-acid diets did not show the same effects.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"4405f918-c17d-5365-b873-1678989f8ac1","slug":"cla-trans10-cis12","display_name":"trans-10,cis-12 conjugated linoleic acid","entity_type_key":"small_molecule"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"379cafac-b5aa-5eac-83fe-ae357f9ede01","slug":"mouse-hepatic-lipid-accumulation","display_name":"Mouse hepatic lipid accumulation","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"8e9622fd-f3a4-526b-9ab5-7389d768d937","slug":"mouse-pparg","display_name":"Mouse peroxisome proliferator-activated receptor gamma / Pparg","entity_type_key":"protein"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"a85c068b-9c0b-5a08-bad7-66ff3ef2af19","slug":"cla-cis9-trans11","display_name":"cis-9,trans-11 conjugated linoleic acid / rumenic acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"8744fb0d-739e-52cc-ac18-2f00ac889720","slug":"linoleic-acid","display_name":"Linoleic acid","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Mouse dietary comparison.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"Not a human risk estimate or proof that insulin caused the liver phenotype.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"CLA collection; isomer, preparation, species, exposure and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"conjugated-linoleic-acid","display_name":"Conjugated linoleic acid / CLA isomer family","entity_type_key":"chemical_species"}},{"dimension":"plain_language","value_text":"Loss of adipose fat coexisted with liver fat accumulation.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Dietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12235171/ · DOI 10.1194/jlr.m20008-jlr200","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"cf9319f1-d60f-559e-a74d-7db2cf30a53a","evidence_kind":"source_excerpt","locator":"Lines 214-220","start_line":214,"end_line":220,"excerpt":"## cla-mouse-liver\nLoss of adipose fat coexisted with liver fat accumulation.\nFeeding 0.4% t10,c12 CLA for four weeks produced fatty liver, hyperinsulinemia and lipoatrophy; c9,t11 and linoleic-acid diets did not show the same effects.\nModel: Mouse dietary comparison.\nLimitations: Not a human risk estimate or proof that insulin caused the liver phenotype.\nEvidence access: Primary abstract\nDietary trans-10,cis-12 conjugated linoleic acid induces hyperinsulinemia and fatty liver in the mouse. · 2002 · https://pubmed.ncbi.nlm.nih.gov/12235171/ · DOI 10.1194/jlr.m20008-jlr200","model_system":"Mouse dietary comparison.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; evidence access and experimental limitations specified.","relationship":"supports","weight":1.0,"link_notes":"","source":{"id":"45cfa6e3-2e7d-57c1-8c35-65302b7b71db","stable_key":"import-ee4227e5-80d7-55e9-ada7-3c5a16f93ac9","title":"Conjugated linoleic acid: isomers, signaling, nutrient interactions and discovery (2026-09-19)","document_type":"imported_text","citation_label":"AI-assisted research curation; primary-abstract references and experimental limitations individually identified. Not publisher full text.","file_path":"","sha256":"f9fe73a8a4008d52061c65abe6de7a9806da75f1c478c5adace9387b8ffaad9e","revision_id":"21196d9c-aaab-5fe1-8f32-2987c94289c6","review_status":"unverified_draft","notes":""}}],"relations":[],"conflicts":[],"corrections":[],"research":null}