Component

Rebaudioside A

Context-specific entity; species, compartment and exposure are stated on each claim.

13 recorded relationships. Experimental role, claim status and evidence remain attached to each record.

Read recorded mechanisms Open recursive mind map

How nutrients influence it

Every nutrient with a recorded effect on this component, credited to the nutrient that acted rather than the chapter that recorded it. Open a nutrient to see the findings and the conditions they were measured under.

How nutrients reach it in more than one step

Chains of two or more recorded steps that end here, grouped by the nutrient they start from. Each step is a separate finding, so a chain is a route a mechanism could take, not proof that it does.

Tracing routes…

What it does

Every recorded relationship this component is part of, grouped by its role. Plain wording comes first; the technical statement follows.

Recorded relationships

What it acts on

  1. A 16-week trial of 1000 mg/day rebaudioside A in 60 adults versus 62 placebo recipients with type 2 diabetes found no significant difference in HbA1c, fasting glucose, insulin or C-peptide changes.

    Rebaudioside A → Human HbA1c after 16-week rebaudioside A source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Controlled human intervention; ages 33–75.
    limitations
    This evaluates a particular purified glycoside and regimen, not every possible extract or sugar-replacement strategy.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    A longer human study did not confirm a general antidiabetic effect.
    primary_references
    Chronic consumption of rebaudioside A, a steviol glycoside, in men and women with type 2 diabetes mellitus. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18555575/ · DOI 10.1016/j.fct.2008.05.007

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 378–384

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Controlled human intervention; ages 33–75. · source_derived_draft · unverified_draft

    ## stevia-chronic-reba-null A longer human study did not confirm a general antidiabetic effect. A 16-week trial of 1000 mg/day rebaudioside A in 60 adults versus 62 placebo recipients with type 2 diabetes found no significant difference in HbA1c, fasting glucose, insulin or C-peptide changes. Model: Controlled human intervention; ages 33–75. Limitations: This evaluates a particular purified glycoside and regimen, not every possible extract or sugar-replacement strategy. Evidence access: Primary abstract Chronic consumption of rebaudioside A, a steviol glycoside, in men and women with type 2 diabetes mellitus. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18555575/ · DOI 10.1016/j.fct.2008.05.007
    Complete structured claim and evidence

  2. Rebaudioside A concentration-dependently stimulated GLP-1 release in human HuTu-80 enteroendocrine cells.

    Rebaudioside A → Human HuTu-80 GLP-1 release source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human HuTu-80 cells, with separate mouse STC-1 experiments.
    limitations
    The accessed abstract does not provide the tested concentration range; no oral human GLP-1 response is asserted.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    An intestinal cell sensor can connect exposure to hormone release.
    primary_references
    Rebaudioside A from Stevia rebaudiana stimulates GLP-1 release by enteroendocrine cells via bitter taste signalling pathways. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37431625/ · DOI 10.1039/d3fo00818e

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 258–264

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human HuTu-80 cells, with separate mouse STC-1 experiments. · source_derived_draft · unverified_draft

    ## stevia-gut-glp1 An intestinal cell sensor can connect exposure to hormone release. Rebaudioside A concentration-dependently stimulated GLP-1 release in human HuTu-80 enteroendocrine cells. Model: Human HuTu-80 cells, with separate mouse STC-1 experiments. Limitations: The accessed abstract does not provide the tested concentration range; no oral human GLP-1 response is asserted. Evidence access: Primary abstract Rebaudioside A from Stevia rebaudiana stimulates GLP-1 release by enteroendocrine cells via bitter taste signalling pathways. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37431625/ · DOI 10.1039/d3fo00818e
    Complete structured claim and evidence

  3. Median plasma steviol-glucuronide peak times were 12 hours after rebaudioside A and 8 hours after stevioside; elimination half-lives were approximately 14 hours.

    Rebaudioside A → Human steviol-glucuronide time to peak source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Same crossover study in healthy men.
    limitations
    Group medians do not predict one person or another formulation.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    An oral sweet taste and a circulating metabolite peak occur on different timelines.
    primary_references
    Pharmacokinetics of rebaudioside A and stevioside after single oral doses in healthy men. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18555578/ · DOI 10.1016/j.fct.2008.04.041
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 82–88

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Same crossover study in healthy men. · source_derived_draft · unverified_draft

    ## stevia-human-timing An oral sweet taste and a circulating metabolite peak occur on different timelines. Median plasma steviol-glucuronide peak times were 12 hours after rebaudioside A and 8 hours after stevioside; elimination half-lives were approximately 14 hours. Model: Same crossover study in healthy men. Limitations: Group medians do not predict one person or another formulation. Evidence access: Primary abstract Pharmacokinetics of rebaudioside A and stevioside after single oral doses in healthy men. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18555578/ · DOI 10.1016/j.fct.2008.04.041
    Complete structured claim and evidence

  4. Following a single 3 g oral dose, rebaudioside A was detected in plasma as early as one hour in nearly all participants; steviol and its glucuronide peaked at 19.5 hours.

    Rebaudioside A → Human plasma rebaudioside A source_derived_draftungraded
    Experimental context and source evidence
    availability_state
    biomarker_context Imported condition classification; unverified.
    evidence_access
    Primary abstract
    experimental_model
    Thirty adults with type 2 diabetes; open-label randomized placebo crossover; metformin or no therapy.
    limitations
    This does not establish the fraction absorbed intact or justify a blanket statement that glycosides are never absorbed.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    Some intact parent compound can be detected after a large dose.
    primary_references
    Pharmacokinetics of Oral Rebaudioside A in Patients with Type 2 Diabetes Mellitus and Its Effects on Glucose Homeostasis: A Placebo-Controlled Crossover Trial. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36057030/ · DOI 10.1007/s13318-022-00792-7
    trigger_kind
    biomarker_context Imported condition classification; unverified.

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 90–96

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Thirty adults with type 2 diabetes; open-label randomized placebo crossover; metformin or no therapy. · source_derived_draft · unverified_draft

    ## stevia-intact-reba Some intact parent compound can be detected after a large dose. Following a single 3 g oral dose, rebaudioside A was detected in plasma as early as one hour in nearly all participants; steviol and its glucuronide peaked at 19.5 hours. Model: Thirty adults with type 2 diabetes; open-label randomized placebo crossover; metformin or no therapy. Limitations: This does not establish the fraction absorbed intact or justify a blanket statement that glycosides are never absorbed. Evidence access: Primary abstract Pharmacokinetics of Oral Rebaudioside A in Patients with Type 2 Diabetes Mellitus and Its Effects on Glucose Homeostasis: A Placebo-Controlled Crossover Trial. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36057030/ · DOI 10.1007/s13318-022-00792-7
    Complete structured claim and evidence

  5. Rebaudioside A was completely hydrolyzed to steviol in 24 hours in the same human fecal culture experiments.

    Rebaudioside A → Steviol source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Anaerobic fecal cultures; isolated bacterial groups.
    limitations
    Rate differences depend on culture conditions and microbial composition.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    Closely related glycosides can reach a shared metabolite at different rates.
    primary_references
    Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora. · 2003 · https://pubmed.ncbi.nlm.nih.gov/14558786/ · DOI 10.1021/jf0303619

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 26–32

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Anaerobic fecal cultures; isolated bacterial groups. · source_derived_draft · unverified_draft

    ## stevia-microbial-reba Closely related glycosides can reach a shared metabolite at different rates. Rebaudioside A was completely hydrolyzed to steviol in 24 hours in the same human fecal culture experiments. Model: Anaerobic fecal cultures; isolated bacterial groups. Limitations: Rate differences depend on culture conditions and microbial composition. Evidence access: Primary abstract Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora. · 2003 · https://pubmed.ncbi.nlm.nih.gov/14558786/ · DOI 10.1021/jf0303619
    Complete structured claim and evidence

  6. Rebaudioside A at 1 nM increased the ATP/ADP ratio at 16.7 mM glucose while not changing measured cAMP.

    Rebaudioside A → Mouse islet ATP-to-ADP ratio source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Mouse islet nucleotide assays; the same paper reports reduced KATP conductance.
    limitations
    The causal chain from nucleotide change to conductance was proposed rather than isolated by every possible intervention.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    Energy state may connect a glycoside response to potassium-channel closure.
    primary_references
    Rebaudioside A directly stimulates insulin secretion from pancreatic beta cells: a glucose-dependent action via inhibition of ATP-sensitive K-channels. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18435771/ · DOI 10.1111/j.1463-1326.2008.00864.x

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 242–248

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse islet nucleotide assays; the same paper reports reduced KATP conductance. · source_derived_draft · unverified_draft

    ## stevia-reba-atp Energy state may connect a glycoside response to potassium-channel closure. Rebaudioside A at 1 nM increased the ATP/ADP ratio at 16.7 mM glucose while not changing measured cAMP. Model: Mouse islet nucleotide assays; the same paper reports reduced KATP conductance. Limitations: The causal chain from nucleotide change to conductance was proposed rather than isolated by every possible intervention. Evidence access: Primary abstract Rebaudioside A directly stimulates insulin secretion from pancreatic beta cells: a glucose-dependent action via inhibition of ATP-sensitive K-channels. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18435771/ · DOI 10.1111/j.1463-1326.2008.00864.x
    Complete structured claim and evidence

  7. In 30 adults with type 2 diabetes, 3 g oral rebaudioside A did not reduce two-hour OGTT glucose AUC versus placebo at the planned metabolite-peak time; insulin and C-peptide excursions were also comparable.

    Rebaudioside A → Human OGTT glucose AUC after rebaudioside A source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Randomized open-label crossover; OGTT 19 hours after dosing.
    limitations
    Different molecule and test timing from the stevioside meal trial; not an automatic contradiction.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    Measurable circulating metabolites did not guarantee a glucose-lowering response.
    primary_references
    Pharmacokinetics of Oral Rebaudioside A in Patients with Type 2 Diabetes Mellitus and Its Effects on Glucose Homeostasis: A Placebo-Controlled Crossover Trial. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36057030/ · DOI 10.1007/s13318-022-00792-7

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 370–376

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Randomized open-label crossover; OGTT 19 hours after dosing. · source_derived_draft · unverified_draft

    ## stevia-reba-ogtt-null Measurable circulating metabolites did not guarantee a glucose-lowering response. In 30 adults with type 2 diabetes, 3 g oral rebaudioside A did not reduce two-hour OGTT glucose AUC versus placebo at the planned metabolite-peak time; insulin and C-peptide excursions were also comparable. Model: Randomized open-label crossover; OGTT 19 hours after dosing. Limitations: Different molecule and test timing from the stevioside meal trial; not an automatic contradiction. Evidence access: Primary abstract Pharmacokinetics of Oral Rebaudioside A in Patients with Type 2 Diabetes Mellitus and Its Effects on Glucose Homeostasis: A Placebo-Controlled Crossover Trial. · 2022 · https://pubmed.ncbi.nlm.nih.gov/36057030/ · DOI 10.1007/s13318-022-00792-7
    Complete structured claim and evidence

  8. Rebaudioside A increased calcium-activated TRPM5 currents in the expression system.

    Rebaudioside A → TRPM5 channel in the 2017 expression assay, construct species not independently verified source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary full text; Figure 1
    experimental_model
    HEK293T channel-expression patch clamp.
    limitations
    This direct bath exposure is not an oral human exposure study.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    A second glycoside reaches the same channel endpoint.
    primary_references
    Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28361903/ · DOI 10.1038/ncomms14733

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 178–184

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · HEK293T channel-expression patch clamp. · source_derived_draft · unverified_draft

    ## stevia-trpm5-reba A second glycoside reaches the same channel endpoint. Rebaudioside A increased calcium-activated TRPM5 currents in the expression system. Model: HEK293T channel-expression patch clamp. Limitations: This direct bath exposure is not an oral human exposure study. Evidence access: Primary full text; Figure 1 Steviol glycosides enhance pancreatic beta-cell function and taste sensation by potentiation of TRPM5 channel activity. · 2017 · https://pubmed.ncbi.nlm.nih.gov/28361903/ · DOI 10.1038/ncomms14733
    Complete structured claim and evidence

Where it participates (unsigned role)

  1. Among the tested intestinal bacterial groups, Bacteroides isolates most efficiently hydrolyzed stevioside and rebaudioside A to steviol.

    Bacteroides isolates in the human fecal stevia assay → Microbial production of steviol source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Selected bacterial isolates and mixed fecal cultures.
    limitations
    The experiment does not prove a single necessary species or a clinical probiotic strategy.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    Which microbes are present can influence conversion capacity.
    primary_references
    Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora. · 2003 · https://pubmed.ncbi.nlm.nih.gov/14558786/ · DOI 10.1021/jf0303619

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 34–40

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Selected bacterial isolates and mixed fecal cultures. · source_derived_draft · unverified_draft

    ## stevia-bacteroides Which microbes are present can influence conversion capacity. Among the tested intestinal bacterial groups, Bacteroides isolates most efficiently hydrolyzed stevioside and rebaudioside A to steviol. Model: Selected bacterial isolates and mixed fecal cultures. Limitations: The experiment does not prove a single necessary species or a clinical probiotic strategy. Evidence access: Primary abstract Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora. · 2003 · https://pubmed.ncbi.nlm.nih.gov/14558786/ · DOI 10.1021/jf0303619
    Complete structured claim and evidence

  2. The study reported that GABA and 6-methoxyflavanone can modulate rebaudioside-A-dependent GLP-1 release.

    Gamma-aminobutyric acid → Rebaudioside-A GLP-1 modulation assay, cell-specific assignment unresolved source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Mouse and human enteroendocrine signaling study; direction and cell-specific exposure unresolved in the accessed abstract.
    limitations
    This is recorded only as context-dependent modulation; no direction, effective dietary dose or supplement synergy is inferred.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    Other dietary compounds may change a response at a shared signaling system.
    primary_references
    Rebaudioside A from Stevia rebaudiana stimulates GLP-1 release by enteroendocrine cells via bitter taste signalling pathways. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37431625/ · DOI 10.1039/d3fo00818e

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 282–288

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Mouse and human enteroendocrine signaling study; direction and cell-specific exposure unresolved in the accessed abstract. · source_derived_draft · unverified_draft

    ## stevia-gut-gaba Other dietary compounds may change a response at a shared signaling system. The study reported that GABA and 6-methoxyflavanone can modulate rebaudioside-A-dependent GLP-1 release. Model: Mouse and human enteroendocrine signaling study; direction and cell-specific exposure unresolved in the accessed abstract. Limitations: This is recorded only as context-dependent modulation; no direction, effective dietary dose or supplement synergy is inferred. Evidence access: Primary abstract Rebaudioside A from Stevia rebaudiana stimulates GLP-1 release by enteroendocrine cells via bitter taste signalling pathways. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37431625/ · DOI 10.1039/d3fo00818e
    Complete structured claim and evidence

  3. Inhibitor experiments in human HuTu-80 cells supported TAS2R4 involvement in rebaudioside-A-evoked GLP-1 release.

    Human bitter taste receptor / TAS2R4 → Human HuTu-80 GLP-1 release source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human cell-line pharmacology; sweet-signaling inhibition did not explain the response.
    limitations
    Pharmacological inhibition does not establish exclusive receptor involvement or in vivo necessity.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    A bitter receptor participates in a gut-hormone response.
    primary_references
    Rebaudioside A from Stevia rebaudiana stimulates GLP-1 release by enteroendocrine cells via bitter taste signalling pathways. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37431625/ · DOI 10.1039/d3fo00818e

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 266–272

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human cell-line pharmacology; sweet-signaling inhibition did not explain the response. · source_derived_draft · unverified_draft

    ## stevia-gut-tas2r4 A bitter receptor participates in a gut-hormone response. Inhibitor experiments in human HuTu-80 cells supported TAS2R4 involvement in rebaudioside-A-evoked GLP-1 release. Model: Human cell-line pharmacology; sweet-signaling inhibition did not explain the response. Limitations: Pharmacological inhibition does not establish exclusive receptor involvement or in vivo necessity. Evidence access: Primary abstract Rebaudioside A from Stevia rebaudiana stimulates GLP-1 release by enteroendocrine cells via bitter taste signalling pathways. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37431625/ · DOI 10.1039/d3fo00818e
    Complete structured claim and evidence

  4. The human HuTu-80 experiments also supported TRPM5 involvement in rebaudioside-A-evoked GLP-1 release.

    Human calcium-activated monovalent cation channel / TRPM5 → Human HuTu-80 GLP-1 release source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Human enteroendocrine cell-line signaling experiments.
    limitations
    The species-specific human protein node is distinct from mouse Trpm5 and the incompletely resolved expression construct.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    Taste-associated ion-channel machinery is shared with intestinal signaling.
    primary_references
    Rebaudioside A from Stevia rebaudiana stimulates GLP-1 release by enteroendocrine cells via bitter taste signalling pathways. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37431625/ · DOI 10.1039/d3fo00818e

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 274–280

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Human enteroendocrine cell-line signaling experiments. · source_derived_draft · unverified_draft

    ## stevia-gut-trpm5 Taste-associated ion-channel machinery is shared with intestinal signaling. The human HuTu-80 experiments also supported TRPM5 involvement in rebaudioside-A-evoked GLP-1 release. Model: Human enteroendocrine cell-line signaling experiments. Limitations: The species-specific human protein node is distinct from mouse Trpm5 and the incompletely resolved expression construct. Evidence access: Primary abstract Rebaudioside A from Stevia rebaudiana stimulates GLP-1 release by enteroendocrine cells via bitter taste signalling pathways. · 2023 · https://pubmed.ncbi.nlm.nih.gov/37431625/ · DOI 10.1039/d3fo00818e
    Complete structured claim and evidence

  5. After single oral rebaudioside A or stevioside doses in healthy men, urinary steviol glucuronide accounted for 59% and 62% of the respective doses during 72-hour collection.

    Steviol glucuronide → Human urinary steviol-glucuronide elimination source_derived_draftungraded
    Experimental context and source evidence
    evidence_access
    Primary abstract
    experimental_model
    Randomized double-blind crossover pharmacokinetic study; dose values not specified in the accessed abstract.
    limitations
    Incomplete recovery is not evidence of permanent retention. These are healthy adult male pharmacokinetics.
    nutrient_topic
    Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit. · Stevia
    plain_language
    The conjugated metabolite is a major measured urinary exit route.
    primary_references
    Pharmacokinetics of rebaudioside A and stevioside after single oral doses in healthy men. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18555578/ · DOI 10.1016/j.fct.2008.04.041

    Stevia: glycoside metabolism, taste, ion channels and cross-nutrient mechanisms (2026-09-19) · lines 74–80

    AI-assisted research curation; primary references, access levels and experimental limitations individually identified. Not publisher full text. · supports · Randomized double-blind crossover pharmacokinetic study; dose values not specified in the accessed abstract. · source_derived_draft · unverified_draft

    ## stevia-human-urine The conjugated metabolite is a major measured urinary exit route. After single oral rebaudioside A or stevioside doses in healthy men, urinary steviol glucuronide accounted for 59% and 62% of the respective doses during 72-hour collection. Model: Randomized double-blind crossover pharmacokinetic study; dose values not specified in the accessed abstract. Limitations: Incomplete recovery is not evidence of permanent retention. These are healthy adult male pharmacokinetics. Evidence access: Primary abstract Pharmacokinetics of rebaudioside A and stevioside after single oral doses in healthy men. · 2008 · https://pubmed.ncbi.nlm.nih.gov/18555578/ · DOI 10.1016/j.fct.2008.04.041
    Complete structured claim and evidence

In the sources

Preserved passages that mention this component, quoted exactly. Open one to read it in context.

    This is a research prototype built from draft material. It is not medical advice, and its statements still await verification against the original studies.

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