{"id":"aa21bc71-3476-5eba-b107-55fa29b892a7","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-bacteroides","predicate":"supports","statement":"Among the tested intestinal bacterial groups, Bacteroides isolates most efficiently hydrolyzed stevioside and rebaudioside A to steviol.","claim_class":"mechanistic","status":"source_derived_draft","evidence_grade":"ungraded","direction":"context_dependent","is_public":true,"mechanism_event_id":"9fb9803f-9a92-5505-b3eb-779d1d64fb54","mechanism_event_label":"Which microbes are present can influence conversion capacity.","subject":{"id":"f92ee5ea-6489-563d-9f58-114008f362d6","slug":"human-fecal-bacteroides-stevia-assay","display_name":"Bacteroides isolates in the human fecal stevia assay","entity_type_key":"organism"},"object":{"id":"346c7dd8-ec6c-5b3a-9681-fdb48a00a87d","slug":"microbial-steviol-production","display_name":"Microbial production of steviol","entity_type_key":"cellular_process"},"evidence_count":1,"mechanism_event":{"id":"9fb9803f-9a92-5505-b3eb-779d1d64fb54","stable_key":"6b15b2de-9ce9-5b6f-ab8b-3c7dbb4c15c7:stevia-bacteroides-event","event_type":"observed_relationship","label":"Which microbes are present can influence conversion capacity.","description":"Among the tested intestinal bacterial groups, Bacteroides isolates most efficiently hydrolyzed stevioside and rebaudioside A to steviol.","status":"provisional","compartment":null,"participants":[{"entity":{"id":"f92ee5ea-6489-563d-9f58-114008f362d6","slug":"human-fecal-bacteroides-stevia-assay","display_name":"Bacteroides isolates in the human fecal stevia assay","entity_type_key":"organism"},"role":"subject","stoichiometry":null,"state_label":"","sequence_order":0,"notes":""},{"entity":{"id":"346c7dd8-ec6c-5b3a-9681-fdb48a00a87d","slug":"microbial-steviol-production","display_name":"Microbial production of steviol","entity_type_key":"cellular_process"},"role":"target","stoichiometry":null,"state_label":"","sequence_order":1,"notes":""},{"entity":{"id":"c78086c3-7657-589b-b353-1691df2d9f8f","slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":2,"notes":""},{"entity":{"id":"06e03b41-c225-5fa3-8aa3-13a07a9826a9","slug":"stevioside","display_name":"Stevioside","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":3,"notes":""},{"entity":{"id":"16a5658c-2844-5742-9d3b-8882e5414eb6","slug":"rebaudioside-a","display_name":"Rebaudioside A","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":4,"notes":""},{"entity":{"id":"8ba32fe6-183f-5cd5-b386-02e6440e78a0","slug":"steviol","display_name":"Steviol","entity_type_key":"small_molecule"},"role":"context_participant","stoichiometry":null,"state_label":"","sequence_order":5,"notes":""}]},"contexts":[{"dimension":"evidence_access","value_text":"Primary abstract","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"experimental_model","value_text":"Selected bacterial isolates and mixed fecal cultures.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"limitations","value_text":"The experiment does not prove a single necessary species or a clinical probiotic strategy.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"nutrient_topic","value_text":"Stevia collection; species, compartment, exposure, co-substrates and manipulation remain explicit.","comparator":null,"unit":null,"notes":"","entity":{"slug":"stevia","display_name":"Stevia","entity_type_key":"small_molecule"}},{"dimension":"plain_language","value_text":"Which microbes are present can influence conversion capacity.","comparator":null,"unit":null,"notes":"","entity":null},{"dimension":"primary_references","value_text":"Metabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora. · 2003 · https://pubmed.ncbi.nlm.nih.gov/14558786/ · DOI 10.1021/jf0303619","comparator":null,"unit":null,"notes":"","entity":null}],"evidence":[{"id":"3835c281-f143-59a6-90cf-5232ae6d1875","evidence_kind":"source_excerpt","locator":"Lines 34-40","start_line":34,"end_line":40,"excerpt":"## stevia-bacteroides\nWhich microbes are present can influence conversion capacity.\nAmong the tested intestinal bacterial groups, Bacteroides isolates most efficiently hydrolyzed stevioside and rebaudioside A to steviol.\nModel: Selected bacterial isolates and mixed fecal cultures.\nLimitations: The experiment does not prove a single necessary species or a clinical probiotic strategy.\nEvidence access: Primary abstract\nMetabolism of stevioside and rebaudioside A from Stevia rebaudiana extracts by human microflora. · 2003 · https://pubmed.ncbi.nlm.nih.gov/14558786/ · DOI 10.1021/jf0303619","model_system":"Selected bacterial isolates and mixed fecal cultures.","directness":"reported_statement","verification_status":"source_derived_draft","notes":"Original curation paraphrase; 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